AB3G_ARATH
ID AB3G_ARATH Reviewed; 730 AA.
AC Q9ZUU9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=ABC transporter G family member 3;
DE Short=ABC transporter ABCG.3;
DE Short=AtABCG3;
DE AltName: Full=White-brown complex homolog protein 3;
DE Short=AtWBC3;
GN Name=ABCG3; Synonyms=WBC3; OrderedLocusNames=At2g28070; ORFNames=F24D13.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=cv. La-0;
RX PubMed=14506206; DOI=10.1074/mcp.t300006-mcp200;
RA Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT "Large-scale analysis of in vivo phosphorylated membrane proteins by
RT immobilized metal ion affinity chromatography and mass spectrometry.";
RL Mol. Cell. Proteomics 2:1234-1243(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15308754; DOI=10.1105/tpc.104.023150;
RA Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT "Phosphoproteomics of the Arabidopsis plasma membrane and a new
RT phosphorylation site database.";
RL Plant Cell 16:2394-2405(2004).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC98459.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM15328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005851; AAC98459.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC006929; AAM15328.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08075.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62504.1; -; Genomic_DNA.
DR PIR; D84680; D84680.
DR RefSeq; NP_001318302.1; NM_001336143.1.
DR RefSeq; NP_850111.1; NM_179780.1.
DR AlphaFoldDB; Q9ZUU9; -.
DR SMR; Q9ZUU9; -.
DR BioGRID; 2701; 5.
DR STRING; 3702.AT2G28070.1; -.
DR TCDB; 3.A.1.204.19; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q9ZUU9; -.
DR PaxDb; Q9ZUU9; -.
DR PRIDE; Q9ZUU9; -.
DR ProteomicsDB; 244537; -.
DR EnsemblPlants; AT2G28070.1; AT2G28070.1; AT2G28070.
DR EnsemblPlants; AT2G28070.2; AT2G28070.2; AT2G28070.
DR GeneID; 817351; -.
DR Gramene; AT2G28070.1; AT2G28070.1; AT2G28070.
DR Gramene; AT2G28070.2; AT2G28070.2; AT2G28070.
DR KEGG; ath:AT2G28070; -.
DR Araport; AT2G28070; -.
DR TAIR; locus:2046203; AT2G28070.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_7_1; -.
DR InParanoid; Q9ZUU9; -.
DR OMA; FKCNRDT; -.
DR OrthoDB; 806939at2759; -.
DR PRO; PR:Q9ZUU9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUU9; baseline and differential.
DR Genevisible; Q9ZUU9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Membrane; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..730
FT /note="ABC transporter G family member 3"
FT /id="PRO_0000240675"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 114..356
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 441..653
FT /note="ABC transmembrane type-2"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:14506206,
FT ECO:0007744|PubMed:15308754"
SQ SEQUENCE 730 AA; 81039 MW; B99996BA8011A79D CRC64;
MEEIQSQSDL YRSSSSSASS PTSRVPSSHF FYVRKPGSLR QPISFEDSPE WEDTPDVDLR
MEDEAGGGDS INDATTTPVS PSLSKMNSGS MASPPVPEGG AGTGVVRKIA GASIAWKDLT
VTMKGKRKYS DKVVKSSNGY AFPGTMTVIM GPAKSGKSTL LRALAGRLPP SAKMYGEVFV
NGSKSHMPYG SYGFVERETQ LIGSLTVREF LYYSALLQLP GFLFQKRSVV EDAIQAMSLS
DYANKLIGGH CYMKGLRSGE RRRVSIAREL VMRPHILFID EPLYHLDSVS ALLMMVTLKK
LASMGCTLVF TIYQSSTEVF GLFDRICLLS NGNTLFFGET LACLQHFSNA GFPCPIMQSP
SDHFLRAINT DFDRIIAMCK NWQDDNGDFS AVNMDTAVAI RTLEATYKSS ADADSVEAMI
IKLTEREGTQ LKSKGKAGAA TRVAVLTWRS LLVMSREWKY YWLRLILYMI LTLSIGTLYS
GLGHSLSSVA TRVAAVFVFV SFASLLGIAG IPSLLKEIKI YRSEASNQHS GAFVFLLGQF
LGSIPFLFLM SISSSLVFYF MVGLRDDFSL LMYFVLNFFM CLLVNEGLML FIACIWRDVY
WSTLTLISVH VIMMLAAGHF RIRTALPKPV WTYPFAYISF HTYSIEGLLE NEYLGEVFAV
GEVRSISGYQ AIQGNYQISP DTNAKWRNML VLLAMAFGYR LLVYVLLRFG LNKNVSGRLL
LSHKKNNSSR
