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ATS18_HUMAN
ID   ATS18_HUMAN             Reviewed;        1221 AA.
AC   Q8TE60; Q6P4R5; Q6ZWJ9;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   03-AUG-2022, entry version 173.
DE   RecName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 18;
DE            Short=ADAM-TS 18;
DE            Short=ADAM-TS18;
DE            Short=ADAMTS-18;
DE            EC=3.4.24.-;
DE   Flags: Precursor;
GN   Name=ADAMTS18; Synonyms=ADAMTS21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS ILE-626 AND SER-946.
RX   PubMed=11867212; DOI=10.1016/s0378-1119(01)00861-7;
RA   Cal S., Obaya A.J., Llamazares M., Garabaya C., Quesada V., Lopez-Otin C.;
RT   "Cloning, expression analysis, and structural characterization of seven
RT   novel human ADAMTSs, a family of metalloproteinases with disintegrin and
RT   thrombospondin-1 domains.";
RL   Gene 283:49-62(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS HIS-191;
RP   ILE-626 AND ILE-769.
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-1221 (ISOFORM 1), AND VARIANT
RP   ARG-1080.
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [6]
RP   VARIANTS [LARGE SCALE ANALYSIS] LYS-382 AND THR-455.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
RN   [7]
RP   VARIANT LEU-179.
RX   PubMed=21862674; DOI=10.1136/jmedgenet-2011-100306;
RA   Aldahmesh M.A., Khan A.O., Mohamed J.Y., Alkuraya H., Ahmed H., Bobis S.,
RA   Al-Mesfer S., Alkuraya F.S.;
RT   "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome.";
RL   J. Med. Genet. 48:597-601(2011).
RN   [8]
RP   VARIANTS MMCAT PRO-202 AND TRP-577.
RX   PubMed=23818446; DOI=10.1002/humu.22374;
RA   Aldahmesh M.A., Alshammari M.J., Khan A.O., Mohamed J.Y., Alhabib F.A.,
RA   Alkuraya F.S.;
RT   "The syndrome of microcornea, myopic chorioretinal atrophy, and telecanthus
RT   (MMCAT) is caused by mutations in ADAMTS18.";
RL   Hum. Mutat. 34:1195-1199(2013).
RN   [9]
RP   VARIANT LEU-179, AND LACK OF INVOLVEMENT IN KNOBLOCH SYNDROME.
RX   PubMed=23667181; DOI=10.1136/jmedgenet-2013-101755;
RA   Aldahmesh M.A., Khan A.O., Mohamed J.Y., Levin A.V., Wuthisiri W.,
RA   Lynch S., McCreery K., Alkuraya F.S.;
RT   "No evidence for locus heterogeneity in Knobloch syndrome.";
RL   J. Med. Genet. 50:565-566(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8TE60-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TE60-2; Sequence=VSP_015776, VSP_015777;
CC   -!- TISSUE SPECIFICITY: Expressed in fetal lung, liver, and kidney and in
CC       adult brain, prostate, submaxillary gland, and endothelium.
CC   -!- DOMAIN: The conserved cysteine present in the cysteine-switch motif
CC       binds the catalytic zinc ion, thus inhibiting the enzyme. The
CC       dissociation of the cysteine from the zinc ion upon the activation-
CC       peptide release activates the enzyme.
CC   -!- PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
CC   -!- PTM: Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a
CC       threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-
CC       G of the TSP type-1 repeat domains where C1 and C2 are the first and
CC       second cysteine residue of the repeat, respectively. Fucosylated
CC       repeats can then be further glycosylated by the addition of a beta-1,3-
CC       glucose residue by the glucosyltransferase, B3GALTL. Fucosylation
CC       mediates the efficient secretion of ADAMTS family members. Can also be
CC       C-glycosylated with one or two mannose molecules on tryptophan residues
CC       within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated.
CC       These other glycosylations can also facilitate secretion (By
CC       similarity). {ECO:0000250}.
CC   -!- DISEASE: Microcornea, myopic chorioretinal atrophy, and telecanthus
CC       (MMCAT) [MIM:615458]: A ocular syndrome characterized by microcornea
CC       and myopic chorioretinal atrophy. Microcornea is defined by a corneal
CC       diameter inferior to 10 mm in both meridians in an otherwise normal
CC       eye. In addition to ocular findings, some patients have telecanthus and
CC       posteriorly rotated ears. {ECO:0000269|PubMed:23818446}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- CAUTION: Variant Leu-179 has been originally reported as disease-
CC       causing mutation in a patient with Knobloch syndrome (PubMed:21862674).
CC       It has been subsequently shown that Knobloch syndrome in the patient
CC       was due to an intronic mutation in COL18A1. Variant Leu-179 is,
CC       therefore, not responsible for the disease phenotype (PubMed:23667181).
CC       {ECO:0000305|PubMed:21862674, ECO:0000305|PubMed:23667181}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC85503.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAC83612.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305};
CC       Sequence=CAC83612.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR   EMBL; AJ311903; CAC83612.1; ALT_SEQ; mRNA.
DR   EMBL; AC009139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC025284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC063283; AAH63283.1; -; mRNA.
DR   EMBL; AK122677; BAC85503.1; ALT_INIT; mRNA.
DR   CCDS; CCDS10926.1; -. [Q8TE60-1]
DR   RefSeq; NP_955387.1; NM_199355.3. [Q8TE60-1]
DR   AlphaFoldDB; Q8TE60; -.
DR   SMR; Q8TE60; -.
DR   BioGRID; 128084; 8.
DR   IntAct; Q8TE60; 4.
DR   STRING; 9606.ENSP00000282849; -.
DR   MEROPS; M12.028; -.
DR   GlyGen; Q8TE60; 7 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8TE60; -.
DR   PhosphoSitePlus; Q8TE60; -.
DR   BioMuta; ADAMTS18; -.
DR   DMDM; 296439427; -.
DR   MassIVE; Q8TE60; -.
DR   PaxDb; Q8TE60; -.
DR   PeptideAtlas; Q8TE60; -.
DR   PRIDE; Q8TE60; -.
DR   ProteomicsDB; 74402; -. [Q8TE60-1]
DR   ProteomicsDB; 74403; -. [Q8TE60-2]
DR   Antibodypedia; 30389; 157 antibodies from 24 providers.
DR   DNASU; 170692; -.
DR   Ensembl; ENST00000282849.10; ENSP00000282849.5; ENSG00000140873.16. [Q8TE60-1]
DR   GeneID; 170692; -.
DR   KEGG; hsa:170692; -.
DR   MANE-Select; ENST00000282849.10; ENSP00000282849.5; NM_199355.4; NP_955387.1.
DR   UCSC; uc002ffc.4; human. [Q8TE60-1]
DR   CTD; 170692; -.
DR   DisGeNET; 170692; -.
DR   GeneCards; ADAMTS18; -.
DR   HGNC; HGNC:17110; ADAMTS18.
DR   HPA; ENSG00000140873; Group enriched (brain, placenta).
DR   MalaCards; ADAMTS18; -.
DR   MIM; 607512; gene.
DR   MIM; 615458; phenotype.
DR   neXtProt; NX_Q8TE60; -.
DR   OpenTargets; ENSG00000140873; -.
DR   Orphanet; 369970; Microcornea-myopic chorioretinal atrophy-telecanthus syndrome.
DR   PharmGKB; PA24544; -.
DR   VEuPathDB; HostDB:ENSG00000140873; -.
DR   eggNOG; KOG3538; Eukaryota.
DR   GeneTree; ENSGT00940000157553; -.
DR   HOGENOM; CLU_000660_1_0_1; -.
DR   InParanoid; Q8TE60; -.
DR   OMA; REKRSPI; -.
DR   PhylomeDB; Q8TE60; -.
DR   TreeFam; TF313537; -.
DR   PathwayCommons; Q8TE60; -.
DR   Reactome; R-HSA-1474228; Degradation of the extracellular matrix.
DR   Reactome; R-HSA-5083635; Defective B3GALTL causes PpS.
DR   Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins.
DR   SignaLink; Q8TE60; -.
DR   BioGRID-ORCS; 170692; 8 hits in 1067 CRISPR screens.
DR   ChiTaRS; ADAMTS18; human.
DR   GenomeRNAi; 170692; -.
DR   Pharos; Q8TE60; Tbio.
DR   PRO; PR:Q8TE60; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q8TE60; protein.
DR   Bgee; ENSG00000140873; Expressed in cerebellar vermis and 117 other tissues.
DR   ExpressionAtlas; Q8TE60; baseline and differential.
DR   Genevisible; Q8TE60; HS.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IMP:UniProtKB.
DR   GO; GO:0090331; P:negative regulation of platelet aggregation; IDA:MGI.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 6.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR041645; ADAMTS_CR_2.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF19236; ADAM_CR_3; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 6.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cleavage on pair of basic residues; Disease variant;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Hydrolase;
KW   Metal-binding; Metalloprotease; Protease; Reference proteome; Repeat;
KW   Secreted; Signal; Zinc; Zymogen.
FT   SIGNAL          1..47
FT                   /evidence="ECO:0000255"
FT   PROPEP          48..284
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000029200"
FT   CHAIN           285..1221
FT                   /note="A disintegrin and metalloproteinase with
FT                   thrombospondin motifs 18"
FT                   /id="PRO_0000042163"
FT   DOMAIN          293..498
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   DOMAIN          498..577
FT                   /note="Disintegrin"
FT   DOMAIN          589..644
FT                   /note="TSP type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          931..990
FT                   /note="TSP type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          991..1049
FT                   /note="TSP type-1 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          1052..1116
FT                   /note="TSP type-1 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          1123..1178
FT                   /note="TSP type-1 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          1184..1221
FT                   /note="PLAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00233"
FT   REGION          258..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..876
FT                   /note="Spacer"
FT   MOTIF           252..259
FT                   /note="Cysteine switch"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        437
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   BINDING         254
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /note="in inhibited form"
FT                   /evidence="ECO:0000250"
FT   BINDING         436
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   BINDING         440
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   BINDING         446
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        313
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        745
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        838
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        909
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        369..420
FT                   /evidence="ECO:0000250"
FT   DISULFID        395..402
FT                   /evidence="ECO:0000250"
FT   DISULFID        414..493
FT                   /evidence="ECO:0000250"
FT   DISULFID        453..477
FT                   /evidence="ECO:0000250"
FT   DISULFID        521..546
FT                   /evidence="ECO:0000250"
FT   DISULFID        532..553
FT                   /evidence="ECO:0000250"
FT   DISULFID        541..572
FT                   /evidence="ECO:0000250"
FT   DISULFID        566..577
FT                   /evidence="ECO:0000250"
FT   DISULFID        601..638
FT                   /evidence="ECO:0000250"
FT   DISULFID        605..643
FT                   /evidence="ECO:0000250"
FT   DISULFID        616..628
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1064..1082
FT                   /note="CSATCGLGVRKREMKCSEK -> VWIRSHCWVRRLRPSWLTQ (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11867212"
FT                   /id="VSP_015776"
FT   VAR_SEQ         1083..1221
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11867212"
FT                   /id="VSP_015777"
FT   VARIANT         179
FT                   /note="S -> L (in dbSNP:rs387906972)"
FT                   /evidence="ECO:0000269|PubMed:21862674,
FT                   ECO:0000269|PubMed:23667181"
FT                   /id="VAR_066554"
FT   VARIANT         191
FT                   /note="Y -> H (in dbSNP:rs11643211)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_060231"
FT   VARIANT         202
FT                   /note="L -> P (in MMCAT; dbSNP:rs397515468)"
FT                   /evidence="ECO:0000269|PubMed:23818446"
FT                   /id="VAR_070849"
FT   VARIANT         382
FT                   /note="R -> K (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs368783738)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036152"
FT   VARIANT         455
FT                   /note="K -> T (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs776584074)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036153"
FT   VARIANT         577
FT                   /note="C -> W (in MMCAT; dbSNP:rs148319220)"
FT                   /evidence="ECO:0000269|PubMed:23818446"
FT                   /id="VAR_070850"
FT   VARIANT         626
FT                   /note="L -> I (in dbSNP:rs11640912)"
FT                   /evidence="ECO:0000269|PubMed:11867212,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_060232"
FT   VARIANT         769
FT                   /note="L -> I (in dbSNP:rs9930984)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057083"
FT   VARIANT         946
FT                   /note="A -> S (in dbSNP:rs12935394)"
FT                   /evidence="ECO:0000269|PubMed:11867212"
FT                   /id="VAR_057084"
FT   VARIANT         1080
FT                   /note="S -> R (in dbSNP:rs35478105)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_057085"
FT   VARIANT         1159
FT                   /note="S -> T (in dbSNP:rs3743749)"
FT                   /id="VAR_057086"
FT   CONFLICT        410
FT                   /note="I -> T (in Ref. 1; CAC83612)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1221 AA;  135167 MW;  4F662B2D2ABF5CA3 CRC64;
     MECALLLACA FPAAGSGPPR GLAGLGRVAK ALQLCCLCCA SVAAALASDS SSGASGLNDD
     YVFVTPVEVD SAGSYISHDI LHNGRKKRSA QNARSSLHYR FSAFGQELHL ELKPSAILSS
     HFIVQVLGKD GASETQKPEV QQCFYQGFIR NDSSSSVAVS TCAGLSGLIR TRKNEFLISP
     LPQLLAQEHN YSSPAGHHPH VLYKRTAEEK IQRYRGYPGS GRNYPGYSPS HIPHASQSRE
     TEYHHRRLQK QHFCGRRKKY APKPPTEDTY LRFDEYGSSG RPRRSAGKSQ KGLNVETLVV
     ADKKMVEKHG KGNVTTYILT VMNMVSGLFK DGTIGSDINV VVVSLILLEQ EPGGLLINHH
     ADQSLNSFCQ WQSALIGKNG KRHDHAILLT GFDICSWKNE PCDTLGFAPI SGMCSKYRSC
     TINEDTGLGL AFTIAHESGH NFGMIHDGEG NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ
     YLKKFLSTPQ AGCLVDEPKQ AGQYKYPDKL PGQIYDADTQ CKWQFGAKAK LCSLGFVKDI
     CKSLWCHRVG HRCETKFMPA AEGTVCGLSM WCRQGQCVKF GELGPRPIHG QWSAWSKWSE
     CSRTCGGGVK FQERHCNNPK PQYGGLFCPG SSRIYQLCNI NPCNENSLDF RAQQCAEYNS
     KPFRGWFYQW KPYTKVEEED RCKLYCKAEN FEFFFAMSGK VKDGTPCSPN KNDVCIDGVC
     ELVGCDHELG SKAVSDACGV CKGDNSTCKF YKGLYLNQHK ANEYYPVVLI PAGARSIEIQ
     ELQVSSSYLA VRSLSQKYYL TGGWSIDWPG EFPFAGTTFE YQRSFNRPER LYAPGPTNET
     LVFEILMQGK NPGIAWKYAL PKVMNGTPPA TKRPAYTWSI VQSECSVSCG GGYINVKAIC
     LRDQNTQVNS SFCSAKTKPV TEPKICNAFS CPAYWMPGEW STCSKACAGG QQSRKIQCVQ
     KKPFQKEEAV LHSLCPVSTP TQVQACNSHA CPPQWSLGPW SQCSKTCGRG VRKRELLCKG
     SAAETLPESQ CTSLPRPELQ EGCVLGRCPK NSRLQWVASS WSECSATCGL GVRKREMKCS
     EKGFQGKLIT FPERRCRNIK KPNLDLEETC NRRACPAHPV YNMVAGWYSL PWQQCTVTCG
     GGVQTRSVHC VQQGRPSSSC LLHQKPPVLR ACNTNFCPAP EKREDPSCVD FFNWCHLVPQ
     HGVCNHKFYG KQCCKSCTRK I
 
 
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