AB40G_ORYSJ
ID AB40G_ORYSJ Reviewed; 1466 AA.
AC Q8GU85; Q0E1P6;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=ABC transporter G family member 40 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG40 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 4 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR4 {ECO:0000303|PubMed:16506311};
GN Name=ABCG40 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR4 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os02g0318450/Os02g0318500 {ECO:0000312|EMBL:BAF08592.2},
GN LOC_Os02g21340;
GN ORFNames=OJ1134_B09.15 {ECO:0000312|EMBL:BAD27654.1},
GN OSJNBa0086N11.3 {ECO:0000312|EMBL:BAD28939.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD27654.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD28939.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF08592.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD59573.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ535051; CAD59573.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004024; BAD27654.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP005651; BAD28939.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008208; BAF08592.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q8GU85; -.
DR SMR; Q8GU85; -.
DR STRING; 4530.OS02T0318500-00; -.
DR PRIDE; Q8GU85; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_3_1; -.
DR InParanoid; Q8GU85; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1466
FT /note="ABC transporter G family member 40"
FT /id="PRO_0000433452"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1209..1229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1241..1261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1297..1317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1327..1347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1355..1375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1396..1416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1435..1455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 176..449
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 527..740
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 865..1117
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1190..1404
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 209..216
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 910..917
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1466 AA; 165582 MW; E227995868E81CF0 CRC64;
MSHRHHAALV ASASGRSPSW GSAISQSFRQ VEAEDPFRRA QSMRGHDEEE EDLRWAALEK
LPTYDRMRRG VVRSALLRDG DDDHKDDDDA GTGKAVELVD IGRLATGDAA RALVERLLQD
DSERFLRRLR DRIDMVGIEL PKIEIRYEEL SVQADAFVAS RALPTLSNSA INFLQGLIGQ
FGSSNKKTIN ILKQVNGILK SSRMTLLLGP PSSGKSTLMR ALTGKLDKNL KVFGNITYCG
HKFSEFYPER TSAYVSQYDL HNAEMTVRET LDFSRWCLGI GSRYDMLTEI SRRERNAGIK
PDPEIDAFMK ATAMQGQETN IITDLILKVL GLDICADTIV GDEMIRGISG GQMKRVTTGE
MLTGPARALL MDEISTGLDS SSTFHIVKFI RHLVHIMNET VMISLLQPPP ETYNLFDDIV
LLSEGYIVYH GPRENILEFF EASGFRCPQR KAVADFLQEV TSKKDQQQYW FLDKEPYCYV
SVPEFAERFK SFYIGQQMMK EQHIPFEKSK IHPAALTTMK NALSNWESLK AVLCREKLLM
KRNSFLYIFK VTQLIILAFL SMTVFLRTKM PHGQFSDGTK FLGALTFNLI TVMFNGLSEL
NLTVKKLPVF YKHRDFLFFP PWTFGVANIL IKVPVSLVEA TVWVVITYYV MGFAPAAGRF
FRQFLAFFVT HLMAMALFRF LGAILQTMVI AISFGMLVLL IVFVFGGFVI RKNDIRPWWI
WCYWASPMMY SQNAISINEF LASRWAIPNN DTTIDAKTVG EAILKSKGLF TGEWGFWLSI
GALVGFIILF NTLYILALTY LSPIRSANAL VIDEHNETEL YTETRNEEHR SRTSTTTSSI
PTSANGEGNR PTQSQFVLPF QPLSLCFNHL NYYVDMPSEM KQQGLMESRL QLLSDISGAF
RPGLLTALVG VSGAGKTTLM DVLAGRKTSG TIEGSITLSG YSKKQETFAR ISGYCEQADI
HSPNVTVYES ILYSAWLRLP SDVDSNTRKM FVEEVMALVE LDVLCNAMVG LPGVSGLSTE
QRKRLTIAVE LVANPSIIFM DEPTSGLDAR AAAIVMRTVR NTVNTGRTVV CTIHQPSIDI
FESFDELLLL KRGGRVIYAG ELGDHSHKLV EYFETILGVP SITEGYNPAT WMLEVSSTLE
EARMNVDFAE IYANSLLYRK NQELIEELSI PPPGYRDLLF ATKYSQSFYI QCVANLWKQY
KSYWKNPSYN SLRYLTTFLY GLFFGTVFWQ KGTKLDSQQD LYNLLGATYA AIFFIGATNC
MSVQPVVSIE RAVYYRESAA GMYSPLSYAF AQASVEFIYN IIQGILYTVI IYAMIGYDWK
ASKFFYFLFF IVSSFNYFTF FGMMLVACTP SALLANILIT FALPLWNLFA GFLIFRKAIP
IWWRWYYWAN PVSWTIYGVI ASQFGGNGGS ISVPGGSHVA MSQILEDNVG VRHDFLGYVI
LAHFGFMAAF VLIFGYSIKF LNFQKR
