AB41G_ARATH
ID AB41G_ARATH Reviewed; 1397 AA.
AC Q7PC83; F4JJF1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=ABC transporter G family member 41;
DE Short=ABC transporter ABCG.41;
DE Short=AtABCG41;
DE AltName: Full=Pleiotropic drug resistance protein 13;
GN Name=ABCG41; Synonyms=PDR13; OrderedLocusNames=At4g15215;
GN ORFNames=FCAALL.459;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA van den Brule S., Smart C.C.;
RT "The plant PDR family of ABC transporters.";
RL Planta 216:95-106(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Confined to roots. {ECO:0000269|PubMed:12430018}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE83570.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BK001012; DAA00881.1; -; Genomic_DNA.
DR EMBL; AL161540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE83570.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; ANM67534.1; -; Genomic_DNA.
DR RefSeq; NP_001329357.1; NM_001341001.1.
DR RefSeq; NP_680692.1; NM_148326.2.
DR AlphaFoldDB; Q7PC83; -.
DR SMR; Q7PC83; -.
DR BioGRID; 12483; 2.
DR STRING; 3702.AT4G15215.1; -.
DR PaxDb; Q7PC83; -.
DR PRIDE; Q7PC83; -.
DR ProteomicsDB; 244343; -.
DR EnsemblPlants; AT4G15215.11; AT4G15215.11; AT4G15215.
DR GeneID; 827186; -.
DR Gramene; AT4G15215.11; AT4G15215.11; AT4G15215.
DR KEGG; ath:AT4G15215; -.
DR Araport; AT4G15215; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q7PC83; -.
DR OrthoDB; 324553at2759; -.
DR PhylomeDB; Q7PC83; -.
DR PRO; PR:Q7PC83; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q7PC83; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1397
FT /note="ABC transporter G family member 41"
FT /id="PRO_0000234640"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 735..755
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1141..1161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1173..1193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1229..1249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1260..1280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1286..1306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1314..1334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1369..1389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 138..411
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 489..701
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 805..1050
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1122..1336
FT /note="ABC transmembrane type-2 2"
FT BINDING 171..178
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 842..849
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1397 AA; 157239 MW; AB7F544B644799F0 CRC64;
MAQTGEDVDK AKSFQVEFAC GNGVDDEEKL RSQWATVERL PTFKRVTTAL LHTGDDSSDI
IDVTKLEDAE RRLLIEKLVK QIEADNLRLL RKIRKRIDEV GIELPTVEVR FNDLSVEAEC
QVVHGKPIPT LWNTIKGSLS KFVCSKKETK IGILKGVSGI VRPGRMTLLL GPPGCGKTTL
LQALSGRLSH SVKVGGKVSY NGCLLSEFIP EKTSSYISQN DLHIPELSVR ETLDFSACCQ
GIGSRMEIMK EISRREKLKE IVPDPDIDAY MKAISVEGLK NSMQTDYILK ILGLDICADT
RAGDATRPGI SGGQKRRLTT GEIVVGPATT LLMDEISNGL DSSTTFQIVS CLQQLAHIAG
ATILISLLQP APETFELFDD VILLGEGKII YHAPRADICK FFEGCGFKCP ERKGVADFLQ
EVMSRKDQEQ YWCHRSKPYS YISVDSFIKK FNESNLGFLL KEELSKPFDK SQTRKDSLCF
RKYSLSKWEM LKACSRREIL LMKRNSFIYL FKSGLLVFNA LVTMTVFLQA GATRDARHGN
YLMGSMFTAL FRLLADGLPE LTLTISRLGV FCKQKDLYFY PAWAYAIPSI ILRIPLSVLD
SFIWTVLTYY VIGYSPEVGR FFRHFIILLT FHLSCISMFR AIASICRTFV ACSITGAISV
LLLALFGGFV IPKSSMPTWL GWGFWLSPLS YAEIGLTANE FFSPRWRKLT SGNITAGEQV
LDVRGLNFGR HSYWTAFGAL VGFVLFFNAL YTLALTYRNN PQRSRAIVSH GKNSQCSEED
FKPCPEITSR AKTGKVILPF KPLTVTFQNV QYYIETPQGK TRQLLFDITG ALKPGVLTSL
MGVSGAGKTT LLDVLSGRKT RGIIKGEIRV GGYPKVQETF ARVSGYCEQF DIHSPNITVE
ESLKYSAWLR LPYNIDAKTK NELVKEVLET VELEDIKDSM VGLPGISGLS TEQRKRLTIA
VELVSNPSII FLDEPTTGLD ARAAAIVMRA VKNVAETGRT VVCTIHQPSI DIFETFDELI
LMKDGGQLVY YGPLGKHSSK VIKYFESIPG VPKVQKNCNP ATWMLDITCK SAEHRLGMDF
AQAYKDSTLY KENKMVVEQL SSASLGSEAL SFPSRYSQTG WGQLKACLWK QHCSYWRNPS
HNLTRIVFIL LNSLLCSLLF WQKAKDINNQ QDLFSIFGSM YTIVIFSGIN NCATVMNFIA
TERNVFYRER FARMYSSWAY SFSQVLVEVP YSLLQSLLCT IIVYPMIGYH MSVYKMFWSL
YSIFCSLLIF NYCGMLMVAL TPNIHMALTL RSTFFSMVNL FAGFVMPKQK IPKWWIWMYY
LSPTSWVLEG LLSSQYGDVE KEITVFGEKK SVSAFLEDYF GYKHDSLAVV AFVLIAFPII
VASLFAFFMS KLNFQKK
