AB42G_ARATH
ID AB42G_ARATH Reviewed; 1392 AA.
AC Q7PC82; F4JJF3; F4JJF4;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ABC transporter G family member 42;
DE Short=ABC transporter ABCG.42;
DE Short=AtABCG42;
DE AltName: Full=Pleiotropic drug resistance protein 14;
GN Name=ABCG42; Synonyms=PDR14; OrderedLocusNames=At4g15233;
GN ORFNames=FCAALL.460;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA van den Brule S., Smart C.C.;
RT "The plant PDR family of ABC transporters.";
RL Planta 216:95-106(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q7PC82-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Confined to shoots. {ECO:0000269|PubMed:12430018}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE83573.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL161541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE83572.2; -; Genomic_DNA.
DR EMBL; CP002687; AEE83573.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK001013; DAA00882.1; -; Genomic_DNA.
DR RefSeq; NP_001190737.1; NM_001203808.2.
DR RefSeq; NP_001319945.1; NM_001341013.1. [Q7PC82-1]
DR AlphaFoldDB; Q7PC82; -.
DR SMR; Q7PC82; -.
DR STRING; 3702.AT4G15233.2; -.
DR PaxDb; Q7PC82; -.
DR PRIDE; Q7PC82; -.
DR ProteomicsDB; 244585; -. [Q7PC82-1]
DR EnsemblPlants; AT4G15233.1; AT4G15233.1; AT4G15233. [Q7PC82-1]
DR GeneID; 827188; -.
DR Gramene; AT4G15233.1; AT4G15233.1; AT4G15233. [Q7PC82-1]
DR KEGG; ath:AT4G15233; -.
DR Araport; AT4G15233; -.
DR TAIR; locus:504955417; AT4G15233.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q7PC82; -.
DR OrthoDB; 324553at2759; -.
DR PRO; PR:Q7PC82; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q7PC82; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1392
FT /note="ABC transporter G family member 42"
FT /id="PRO_0000234641"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 739..759
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1136..1156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1175..1195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1215..1237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1255..1275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1281..1301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1309..1329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1364..1384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 139..413
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 491..703
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 800..1045
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1117..1331
FT /note="ABC transmembrane type-2 2"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 173..180
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 837..844
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1392 AA; 158222 MW; 8FBBFBC9FB1BBF81 CRC64;
MTMSQTDGVE FASRNTNENG HDDDDQLRSQ WVAIERSPTF ERITTALFCK RDEKGKKSQR
RVMDVSKLDD LDRRLFIDDL IRHVENDNHV LLQKIRKRID EVGIDLPKIE ARFSDLFVEA
ECEVVYGKPI PTLWNAISSK LSRFMCSNQA KKISILKGVS GIIRPKRMTL LLGPPSCGKT
TLLLALSGRL DPSLKTRGDI SYNGHLFSEF VPEKTSSYVS QNDLHIPELS VRETLDFSGC
FQGTGSRLEM TKEISRREKL KGIVPDPDID AYMKAASIEG SKTNLQTDYI LKILGLTICA
DTRVGDASRP GISGGQKRRL TTGEMIVGPI KTLFMDEISN GLDSSTTFQI LSCLQQFARL
SEGTILVSLL QPAPETFELF DDLILMGEGK IIYHGPRDFV CSFFEDCGFK CPNRKSVAEF
LQEVISRKDQ EQYWCHIEKT YCYVSIESFI EKFKKSDLGL ELQDRLSKTY DKSQTQKDGL
CFRKYSLSNW DMLKACSRRE FLLMKRNSFV YVFKSGLLIF IGFIAMTVYL RTGSTRDSLH
ANYLMGSLFF SLFKLLADGL PELTLTISRI AVFCKQKELY FYPAWAYAIP SAILKIPISF
LESFLWTMLT YYVIGYSPEM GRFIRQFLIL FALHLSCISM FRAIAAVFRD FVVATTVGSI
SIVLLSVFGG FIVRKPSMPS WLEWGFWLSP LSYAEIGLTA NEFFAPRWGK ITSENRTLGE
QVLDARGLNF GNQSYWNAFG ALIGFTLFFN TVFALALTFL KTSQRSRVIV SHEKNTQSSE
NDSKIASRFK NALPFEPLTF TFQDVQYIIE TPQGKKLQLL SGVTGAFKPG VLTALMGVSG
AGKTTLLDVL SGRKTFGDIK GQIEVGGYVK VQDTFSRVSG YCEQFDIHSP NLTVQESLKY
SAWLRLTSNI SSETKCAIVN EVLETIELEE IKDSIVGIPG ISGLTTEQRK RLTIAVELVS
NPSIIFMDEP TTGLDARAAA IVMRAVKNIA ETGRTVVCTI HQPSIDIFEA FDELILMKNG
GKIIYYGPLG QHSSKVIEYF MRIHGVPKLK ENSNPATWIL DITSKSSEDK LGVDLAQMYE
ESTLFKENKM VIEQTRCTSL GSERLILSSR YAQTSWEQFK ACLWKQHLSY WRNPSYNLTR
IIFMSFTCML CGILFWQKAK EINNQQDLFN VFGSMFTVVL FSGINNCSTV LFSVATERNV
FYRERFSRMY NSWAYSLAQV LVEIPYSLFQ SIVYVIIVYP MVGYHWSVFK VFWSFYSIFC
TLLIFNYFGM LLVVVTPNVH IAFTLRSSFY AIVNLFAGYV MPKPNIPRWW IWMYYLSPTS
WVLNGLLTSQ YGDMEKEILA FGEKKKVSDF LEDYFGYRYD SLALVAVVLI AFPILLASLF
AFFIGKLNFQ KK
