RPOC_MYCS2
ID RPOC_MYCS2 Reviewed; 1317 AA.
AC A0QS66; I7FY06;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=DNA-directed RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE Short=RNAP subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=Transcriptase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
GN Name=rpoC {ECO:0000255|HAMAP-Rule:MF_01322};
GN OrderedLocusNames=MSMEG_1368, MSMEI_1329;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS], AND IDENTIFICATION OF N-TERMINUS.
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
RN [4]
RP FUNCTION, AND SUBUNIT.
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=19926651; DOI=10.1099/mic.0.033670-0;
RA Dey A., Verma A.K., Chatterji D.;
RT "Role of an RNA polymerase interacting protein, MsRbpA, from Mycobacterium
RT smegmatis in phenotypic tolerance to rifampicin.";
RL Microbiology 156:873-883(2010).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01322, ECO:0000269|PubMed:19926651}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01322};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01322, ECO:0000269|PubMed:19926651}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
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DR EMBL; CP000480; ABK71951.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP37802.1; -; Genomic_DNA.
DR RefSeq; WP_003892756.1; NZ_SIJM01000030.1.
DR RefSeq; YP_885754.1; NC_008596.1.
DR PDB; 5TW1; X-ray; 2.76 A; D=1-1317.
DR PDB; 5VI5; X-ray; 3.20 A; D=1-1317.
DR PDB; 5VI8; X-ray; 2.76 A; D=1-1317.
DR PDB; 6CCE; X-ray; 3.05 A; D=1-1317.
DR PDB; 6CCV; X-ray; 3.05 A; D=1-1317.
DR PDB; 6DCF; X-ray; 3.45 A; D=1-1317.
DR PDB; 6EYD; EM; 4.20 A; D=2-1317.
DR PDB; 6F6W; EM; 3.80 A; D=2-1317.
DR PDB; 6VVS; X-ray; 3.11 A; D=1-1317.
DR PDB; 6VVT; X-ray; 2.90 A; D=1-1317.
DR PDB; 6VVV; X-ray; 3.20 A; D=1-1317.
DR PDB; 6YXU; EM; 3.08 A; D=1-1317.
DR PDB; 6YYS; EM; 3.08 A; D=1-1317.
DR PDB; 6Z11; EM; 3.36 A; D=1-1317.
DR PDB; 7P5X; EM; 3.20 A; AD=1-1317.
DR PDBsum; 5TW1; -.
DR PDBsum; 5VI5; -.
DR PDBsum; 5VI8; -.
DR PDBsum; 6CCE; -.
DR PDBsum; 6CCV; -.
DR PDBsum; 6DCF; -.
DR PDBsum; 6EYD; -.
DR PDBsum; 6F6W; -.
DR PDBsum; 6VVS; -.
DR PDBsum; 6VVT; -.
DR PDBsum; 6VVV; -.
DR PDBsum; 6YXU; -.
DR PDBsum; 6YYS; -.
DR PDBsum; 6Z11; -.
DR PDBsum; 7P5X; -.
DR AlphaFoldDB; A0QS66; -.
DR SMR; A0QS66; -.
DR IntAct; A0QS66; 2.
DR STRING; 246196.MSMEI_1329; -.
DR PRIDE; A0QS66; -.
DR EnsemblBacteria; ABK71951; ABK71951; MSMEG_1368.
DR EnsemblBacteria; AFP37802; AFP37802; MSMEI_1329.
DR GeneID; 66732828; -.
DR KEGG; msg:MSMEI_1329; -.
DR KEGG; msm:MSMEG_1368; -.
DR PATRIC; fig|246196.19.peg.1352; -.
DR eggNOG; COG0086; Bacteria.
DR OMA; YRNIRVE; -.
DR OrthoDB; 4421at2; -.
DR BRENDA; 2.7.7.6; 3512.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.274.100; -; 1.
DR Gene3D; 4.10.860.120; -; 1.
DR HAMAP; MF_01322; RNApol_bact_RpoC; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR012754; DNA-dir_RpoC_beta_prime_bact.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; PTHR19376; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR TIGRFAMs; TIGR02386; rpoC_TIGR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-directed RNA polymerase; Magnesium; Metal-binding;
KW Nucleotidyltransferase; Reference proteome; Transcription; Transferase;
KW Zinc.
FT CHAIN 1..1317
FT /note="DNA-directed RNA polymerase subunit beta'"
FT /id="PRO_0000308855"
FT BINDING 60
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 62
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 75
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 78
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 535
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 537
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 539
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 890
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 967
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 974
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 977
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT STRAND 9..14
FT /evidence="ECO:0007829|PDB:6CCE"
FT HELIX 17..23
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 24..27
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 36..38
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 43..47
FT /evidence="ECO:0007829|PDB:6YYS"
FT TURN 49..52
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 55..58
FT /evidence="ECO:0007829|PDB:6YYS"
FT STRAND 61..64
FT /evidence="ECO:0007829|PDB:6VVT"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 87..90
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 92..102
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 104..108
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 109..111
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 113..118
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 122..129
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 132..139
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 141..146
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 148..186
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 191..228
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 239..246
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 249..251
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 252..255
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 257..266
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 270..283
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 287..304
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 305..307
FT /evidence="ECO:0007829|PDB:6CCE"
FT HELIX 309..312
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 313..319
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 322..324
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 327..329
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 331..333
FT /evidence="ECO:0007829|PDB:6CCE"
FT STRAND 335..337
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 339..360
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 364..382
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 383..389
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 394..396
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 402..406
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 408..411
FT /evidence="ECO:0007829|PDB:6VVT"
FT HELIX 412..416
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 418..432
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 440..444
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 445..462
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 463..465
FT /evidence="ECO:0007829|PDB:6VVT"
FT STRAND 466..468
FT /evidence="ECO:0007829|PDB:6VVT"
FT HELIX 469..477
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 483..491
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 496..499
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 506..508
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 509..524
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 526..528
FT /evidence="ECO:0007829|PDB:6VVT"
FT HELIX 529..532
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 536..538
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 540..544
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 549..557
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 561..563
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 568..570
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 573..576
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 580..589
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 604..606
FT /evidence="ECO:0007829|PDB:6VVT"
FT STRAND 610..613
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 615..623
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 624..626
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 634..641
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 645..650
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 652..654
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 661..664
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 667..673
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 689..702
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 705..725
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 732..734
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 741..760
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 762..764
FT /evidence="ECO:0007829|PDB:6YXU"
FT HELIX 766..791
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 794..796
FT /evidence="ECO:0007829|PDB:5VI5"
FT HELIX 797..803
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 804..807
FT /evidence="ECO:0007829|PDB:5VI5"
FT HELIX 810..816
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 828..830
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 839..841
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 845..880
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 885..888
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 896..898
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 901..903
FT /evidence="ECO:0007829|PDB:6Z11"
FT STRAND 904..908
FT /evidence="ECO:0007829|PDB:6YXU"
FT HELIX 913..915
FT /evidence="ECO:0007829|PDB:6YXU"
FT TURN 916..921
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 924..926
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 931..933
FT /evidence="ECO:0007829|PDB:6CCE"
FT STRAND 935..937
FT /evidence="ECO:0007829|PDB:6CCE"
FT STRAND 942..944
FT /evidence="ECO:0007829|PDB:6YXU"
FT HELIX 945..954
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 959..961
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 964..966
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 970..974
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 975..978
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 982..984
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 985..987
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 994..1003
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1004..1008
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1021..1023
FT /evidence="ECO:0007829|PDB:6YYS"
FT HELIX 1029..1036
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1042..1045
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1052..1058
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1063..1069
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1070..1073
FT /evidence="ECO:0007829|PDB:6YXU"
FT STRAND 1076..1078
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1083..1085
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1093..1095
FT /evidence="ECO:0007829|PDB:6YYS"
FT STRAND 1113..1117
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1119..1126
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1128..1145
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1152..1162
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1163..1169
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1172..1175
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1181..1183
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1184..1192
FT /evidence="ECO:0007829|PDB:5TW1"
FT TURN 1196..1199
FT /evidence="ECO:0007829|PDB:6YXU"
FT STRAND 1204..1207
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1211..1216
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1221..1227
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1230..1240
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1249..1255
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1262..1264
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1266..1269
FT /evidence="ECO:0007829|PDB:5TW1"
FT STRAND 1272..1275
FT /evidence="ECO:0007829|PDB:5TW1"
FT HELIX 1277..1282
FT /evidence="ECO:0007829|PDB:5TW1"
SQ SEQUENCE 1317 AA; 146513 MW; 2C9C7E156E76FBEA CRC64;
MLDVNFFDEL RIGLATADDI RNWSYGEVKK PETINYRTLK PEKDGLFCEK IFGPTRDWEC
YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP VTHIWYFKGV PSRLGYLLDL
APKDLEKIIY FAAYVITSVD DEMRHNELST LEAEMAVEKK AVEDQRDADL EARAQKLEAD
LAELEAEGAK SDVRRKVRDS GEREMRQLRD RAQRELDRLD EIWNTFTKLA PKQLIVDEVL
YRELQDRYGE YFTGAMGAES IKKLIENFDI DAEAESLREV IRSGKGQKKL RALKRLKVVA
AFQQSGNSPM GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR NNRLKRLIDL
GAPEIIVNNE KRMLQESVDA LFDNGRRGRP VTGPGNRPLK SLSDLLKGKQ GRFRQNLLGK
RVDYSGRSVI VVGPQLKLHQ CGLPKLMALE LFKPFVMKRL VDLNHAQNIK SAKRMVERQR
PQVWDVLEEV IAEHPVLLNR APTLHRLGIQ AFEPQLVEGK AIQLHPLVCE AFNADFDGDQ
MAVHLPLSAE AQAEARILML SSNNILSPAS GKPLAMPRLD MVTGLYYLTT LVEGATGEYQ
AATKDAPEQG VYSSPAEAIM AMDRGALSVR AKIKVRLTEL RPPTDLEAQL FENGWKPGDA
WTAETTLGRV MFNELLPKSY PFVNEQMHKK VQARIINDLA ERFPMIVVAQ TVDKLKDAGF
YWATRSGVTV SMADVLVPPQ KQEILERHEA EADAIERKYQ RGALNHTERN ESLVKIWQDA
TEEVGKALEE FYPADNPIIT IVKSGATGNL TQTRTLAGMK GLVTNPKGEF IPRPIKSSFR
EGLTVLEYFI NTHGARKGLA DTALRTADSG YLTRRLVDVS QDVIVREHDC ETERGINVTL
AERGPDGTLI RDAHVETSAF ARTLATDAVD ANGNVIIERG HDLGDPAIDA LLAAGITTVK
VRSVLTCTSA TGVCAMCYGR SMATGKLVDI GEAVGIVAAQ SIGEPGTQLT MRTFHQGGVT
GGADIVGGLP RVQELFEARV PRNKAPIADV AGRVRLEESD KFFKITIVPD DGGEEVVYDK
LSKRQRLRVI THEDGTEGVL SDGDHVEVGD QLMEGAADPH EVLRVQGPRE VQIHLVKEVQ
EVYRAQGVSI HDKHIEVIVR QMLRRVTIID SGSTEFLPGS LTERAEFEAE NRRVVAEGGE
PAAGRPVLMG ITKASLATDS WLSAASFQET TRVLTDAAIN CRSDKLNGLK ENVIIGKLIP
AGTGISRYRN IQVQPTEEAR AAAYTIPSYE DQYYSPDFGQ ATGAAVPLDD YGYSDYR
