AB42G_ORYSJ
ID AB42G_ORYSJ Reviewed; 1500 AA.
AC Q5Z9S8; Q0DBK9; Q5Z9S7; Q8GU93;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=ABC transporter G family member 42 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG42 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 12 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR12 {ECO:0000303|PubMed:16506311};
GN Name=ABCG42 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR12 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os06g0554800 {ECO:0000312|EMBL:BAF19764.1},
GN LOC_Os06g36090;
GN ORFNames=P0458E11.3-1 {ECO:0000312|EMBL:BAD53545.1},
GN P0458E11.3-2 {ECO:0000312|EMBL:BAD53546.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5Z9S8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5Z9S8-2; Sequence=VSP_018394, VSP_018395;
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AJ535043; CAD59565.1; -; Genomic_DNA.
DR EMBL; AP003613; BAD53545.1; -; Genomic_DNA.
DR EMBL; AP003613; BAD53546.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF19764.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS98215.1; -; Genomic_DNA.
DR EMBL; AK121182; BAH00354.1; -; mRNA.
DR AlphaFoldDB; Q5Z9S8; -.
DR SMR; Q5Z9S8; -.
DR STRING; 4530.OS06T0554800-01; -.
DR PaxDb; Q5Z9S8; -.
DR PRIDE; Q5Z9S8; -.
DR EnsemblPlants; Os06t0554800-01; Os06t0554800-01; Os06g0554800. [Q5Z9S8-2]
DR Gramene; Os06t0554800-01; Os06t0554800-01; Os06g0554800. [Q5Z9S8-2]
DR eggNOG; KOG0065; Eukaryota.
DR InParanoid; Q5Z9S8; -.
DR OMA; PWFGWIY; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR Genevisible; Q5Z9S8; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1500
FT /note="ABC transporter G family member 42"
FT /id="PRO_0000234650"
FT TRANSMEM 551..571
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 724..744
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 783..803
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1245..1265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1277..1297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1331..1351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1358..1378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1388..1408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1416..1436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1472..1492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 182..455
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 533..746
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 894..1151
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1224..1438
FT /note="ABC transmembrane type-2 2"
FT REGION 26..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 215..222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 939..946
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 1..333
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_018394"
FT VAR_SEQ 334
FT /note="R -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_018395"
FT CONFLICT 81
FT /note="S -> F (in Ref. 1; CAD59565)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1500 AA; 169130 MW; 9F425A5F9C7EA5E0 CRC64;
MEKVWESGRR MSRSIGRGMG MEAWGVDEAF MPQNSGGGGG SRGRRRSGRG GTADDDEEAL
RWAAIERLPT YSRMRTAILS SAEEEAAAAA AGAGKQQYKE VDVRRLGVGE RQEFIERVFR
VAEEDNQRFL QKLRNRIDRV GIELPTVEVR FEELMVQARC HVGSRALPTL LNTARNIAEA
ALGLVGVRPG RQATLTILRG VSGAVRPSRM TLLLGPPSSG KTTLLLALAG KLDPSLRRGG
EVTYNGFELE EFVAQKTAAY ISQTDVHVGE MTVKETLDFS ARCQGVGTKY DLLTELARRE
KEAGIRPEPE VDLFMKATSM EGVESSLQTD YTLRILGLDI CADTIVGDQM QRGISGGQKK
RVTTGEMIVG PTKVLFMDEI STGLDSSTTF QIVKCLQQIV HLGEATILMS LLQPAPETFE
LFDDIILLSE GQIVYQGPRE YVLEFFESCG FRCPERKGTA DFLQEVTSKK DQEQYWADKH
RPYRYISVSE FAQRFKRFHV GLQLENHLSV PFDKTRSHQA ALVFSKQSVS TTELLKASFA
KEWLLIKRNS FVYIFKTIQL IIVALVASTV FLRTQMHTRN LDDGFVYIGA LLFSLIVNMF
NGFAELSLTI TRLPVFFKHR DLLFYPAWIF TLPNVILRIP FSIIESIVWV IVTYYTIGFA
PEADRFFKQL LLVFLIQQMA GGLFRATAGL CRSMIIAQTG GALALLIFFV LGGFLLPKAF
IPKWWIWGYW VSPLMYGYNA LAVNEFYSPR WMNKFVLDNN GVPKRLGIAL MEGANIFTDK
NWFWIGAAGL LGFTMFFNVL FTLSLVYLNP LGKPQAVISE ETAKEAEGNG DARHTVRNGS
TKSNGGNHKE MREMRLSARL SNSSSNGVSR LMSIGSNEAG PRRGMVLPFT PLSMSFDDVN
YYVDMPAEMK QQGVVDDRLQ LLRDVTGSFR PAVLTALMGV SGAGKTTLMD VLAGRKTGGY
IEGDMRISGY PKNQETFARI SGYCEQNDIH SPQVTVRESL IYSAFLRLPE KIGDQEITDD
IKIQFVDEVM ELVELDNLKD ALVGLPGITG LSTEQRKRLT IAVELVANPS IIFMDEPTSG
LDARAAAIVM RTVRNTVDTG RTVVCTIHQP SIDIFEAFDE LLLLKRGGQV IYSGQLGRNS
QKMIEYFEAI PGVPKIKDKY NPATWMLEVS SVAAEVRLNM DFAEYYKTSD LYKQNKVLVN
QLSQPEPGTS DLHFPTKYSQ STIGQFRACL WKQWLTYWRS PDYNLVRFSF TLFTALLLGT
IFWKIGTKMG NANSLRMVIG AMYTAVMFIG INNCATVQPI VSIERTVFYR ERAAGMYSAM
PYAIAQVVME IPYVFVQTAY YTLIVYAMMS FQWTAAKFFW FFFVSYFSFL YFTYYGMMTV
AISPNHEVAA IFAAAFYSLF NLFSGFFIPR PRIPKWWIWY YWLCPLAWTV YGLIVTQYGD
LEQIISVPGQ SNQTISYYVT HHFGYHRKFM PVVAPVLVLF AVFFAFMYAI CIKKLNFQHR
