ATTA_DROME
ID ATTA_DROME Reviewed; 224 AA.
AC P45884; Q9V750;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Attacin-A;
DE Flags: Precursor;
GN Name=AttA; ORFNames=CG10146;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=7742836; DOI=10.1016/0965-1748(94)00091-c;
RA Aasling B., Dushay M.S., Hultmark D.;
RT "Identification of early genes in the Drosophila immune response by PCR-
RT based differential display: the Attacin A gene and the evolution of
RT attacin-like proteins.";
RL Insect Biochem. Mol. Biol. 25:511-518(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10767526; DOI=10.1016/s0378-1119(00)00041-x;
RA Dushay M.S., Roethele J.B., Chaverri J.M., Dulek D.E., Syed S.K.,
RA Kitami T., Eldon E.D.;
RT "Two attacin antibacterial genes of Drosophila melanogaster.";
RL Gene 246:49-57(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY BACTERIA, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Hemolymph {ECO:0000303|PubMed:16510152};
RX PubMed=16510152; DOI=10.1016/j.jinsphys.2005.12.007;
RA Verleyen P., Baggerman G., D'Hertog W., Vierstraete E., Husson S.J.,
RA Schoofs L.;
RT "Identification of new immune induced molecules in the haemolymph of
RT Drosophila melanogaster by 2D-nanoLC MS/MS.";
RL J. Insect Physiol. 52:379-388(2006).
CC -!- FUNCTION: Hemolymph antibacterial protein.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16510152}.
CC -!- TISSUE SPECIFICITY: Hemolymph (at protein level).
CC {ECO:0000269|PubMed:16510152}.
CC -!- INDUCTION: By bacterial infection (at protein level).
CC {ECO:0000269|PubMed:16510152}.
CC -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR EMBL; Z46893; CAA86995.1; -; Genomic_DNA.
DR EMBL; AF220544; AAF70455.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF58215.1; -; Genomic_DNA.
DR RefSeq; NP_523745.1; NM_079021.5.
DR AlphaFoldDB; P45884; -.
DR STRING; 7227.FBpp0086567; -.
DR TCDB; 1.C.115.1.6; the membrane-permeabilizing peptide, atticin (atticin) family.
DR PaxDb; P45884; -.
DR EnsemblMetazoa; FBtr0087437; FBpp0086567; FBgn0012042.
DR GeneID; 36636; -.
DR KEGG; dme:Dmel_CG10146; -.
DR CTD; 36636; -.
DR FlyBase; FBgn0012042; AttA.
DR VEuPathDB; VectorBase:FBgn0012042; -.
DR eggNOG; ENOG502SZ31; Eukaryota.
DR HOGENOM; CLU_108645_0_0_1; -.
DR InParanoid; P45884; -.
DR PhylomeDB; P45884; -.
DR BioGRID-ORCS; 36636; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36636; -.
DR PRO; PR:P45884; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0012042; Expressed in oviduct (Drosophila) and 17 other tissues.
DR ExpressionAtlas; P45884; baseline and differential.
DR Genevisible; P45884; DM.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0019731; P:antibacterial humoral response; IEP:FlyBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:FlyBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEP:FlyBase.
DR GO; GO:0002213; P:defense response to insect; IEP:FlyBase.
DR GO; GO:0006959; P:humoral immune response; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0055093; P:response to hyperoxia; IMP:FlyBase.
DR InterPro; IPR005521; Attacin_C.
DR InterPro; IPR005520; Attacin_N.
DR Pfam; PF03769; Attacin_C; 1.
DR Pfam; PF03768; Attacin_N; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..34
FT /evidence="ECO:0000255"
FT /id="PRO_0000004893"
FT CHAIN 35..224
FT /note="Attacin-A"
FT /id="PRO_0000004894"
FT CONFLICT 3
FT /note="K -> N (in Ref. 3; AAF58215)"
FT /evidence="ECO:0000305"
FT CONFLICT 22..24
FT /note="Missing (in Ref. 3; AAF58215)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 23239 MW; 6B1965557847BBBA CRC64;
MQKTSILIVA LVALFAITEA LPSLPTTGPI RVRRQVLGGS LTSNPAGGAD ARLDLTKGIG
NPNHNVVGQV FAAGNTQSGP VTTGGTLAYN NAGHGASLTK THTPGVKDVF QQEAHANLFN
NGRHNLDAKV FASQNKLANG FEFQRNGAGL DYSHINGHGA SLTHSNFPGI GQQLGLDGRA
NLWSSPNRAT TLDLTGSASK WTSGPFANQK PNFGAGLGLS HHFG
