ATTB_DROME
ID ATTB_DROME Reviewed; 218 AA.
AC Q9V751; Q95NV4; Q95U95; Q95U96;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Attacin-B;
DE Flags: Precursor;
GN Name=AttB; Synonyms=AttB1; ORFNames=CG18372;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10767526; DOI=10.1016/s0378-1119(00)00041-x;
RA Dushay M.S., Roethele J.B., Chaverri J.M., Dulek D.E., Syed S.K.,
RA Kitami T., Eldon E.D.;
RT "Two attacin antibacterial genes of Drosophila melanogaster.";
RL Gene 246:49-57(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC STRAIN=2CPA-1, 2CPA-103, 2CPA-105, 2CPA-118, 2CPA-12, 2CPA-122, 2CPA-129,
RC 2CPA-14, 2CPA-43, 2CPA-46, 2CPA-51, and 2CPA-7;
RX PubMed=11606542; DOI=10.1093/genetics/159.2.659;
RA Lazzaro B.P., Clark A.G.;
RT "Evidence for recurrent paralogous gene conversion and exceptional allelic
RT divergence in the attacin genes of Drosophila melanogaster.";
RL Genetics 159:659-671(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY BACTERIA, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Hemolymph {ECO:0000303|PubMed:16510152};
RX PubMed=16510152; DOI=10.1016/j.jinsphys.2005.12.007;
RA Verleyen P., Baggerman G., D'Hertog W., Vierstraete E., Husson S.J.,
RA Schoofs L.;
RT "Identification of new immune induced molecules in the haemolymph of
RT Drosophila melanogaster by 2D-nanoLC MS/MS.";
RL J. Insect Physiol. 52:379-388(2006).
CC -!- FUNCTION: Hemolymph antibacterial protein.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16510152}.
CC -!- TISSUE SPECIFICITY: Hemolymph (at protein level).
CC {ECO:0000269|PubMed:16510152}.
CC -!- INDUCTION: By bacterial infection (at protein level).
CC {ECO:0000269|PubMed:16510152}.
CC -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR EMBL; AF220546; AAF71234.1; -; Genomic_DNA.
DR EMBL; AY056867; AAL23652.1; -; Genomic_DNA.
DR EMBL; AY056868; AAL23653.1; -; Genomic_DNA.
DR EMBL; AY056869; AAL23654.1; -; Genomic_DNA.
DR EMBL; AY056870; AAL23655.1; -; Genomic_DNA.
DR EMBL; AY056871; AAL23656.1; -; Genomic_DNA.
DR EMBL; AY056872; AAL23657.1; -; Genomic_DNA.
DR EMBL; AY056873; AAL23658.1; -; Genomic_DNA.
DR EMBL; AY056874; AAL23659.1; -; Genomic_DNA.
DR EMBL; AY056875; AAL23660.1; -; Genomic_DNA.
DR EMBL; AY056876; AAL23661.1; -; Genomic_DNA.
DR EMBL; AY056877; AAL23662.1; -; Genomic_DNA.
DR EMBL; AY056878; AAL23663.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF58214.1; -; Genomic_DNA.
DR RefSeq; NP_001163152.1; NM_001169681.2.
DR RefSeq; NP_523746.1; NM_079022.3.
DR AlphaFoldDB; Q9V751; -.
DR BioGRID; 62383; 2.
DR IntAct; Q9V751; 5.
DR STRING; 7227.FBpp0086568; -.
DR PaxDb; Q9V751; -.
DR DNASU; 36637; -.
DR GeneID; 36637; -.
DR KEGG; dme:Dmel_CG18372; -.
DR CTD; 36637; -.
DR FlyBase; FBgn0041581; AttB.
DR VEuPathDB; VectorBase:FBgn0012042; -.
DR eggNOG; ENOG502SZ31; Eukaryota.
DR HOGENOM; CLU_108645_0_0_1; -.
DR InParanoid; Q9V751; -.
DR PhylomeDB; Q9V751; -.
DR BioGRID-ORCS; 36637; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36637; -.
DR PRO; PR:Q9V751; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR ExpressionAtlas; Q9V751; baseline and differential.
DR Genevisible; Q9V751; DM.
DR GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0019731; P:antibacterial humoral response; IEP:FlyBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEP:FlyBase.
DR GO; GO:0002213; P:defense response to insect; IEP:FlyBase.
DR GO; GO:0006959; P:humoral immune response; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR005521; Attacin_C.
DR InterPro; IPR005520; Attacin_N.
DR Pfam; PF03769; Attacin_C; 1.
DR Pfam; PF03768; Attacin_N; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..28
FT /evidence="ECO:0000255"
FT /id="PRO_0000004895"
FT CHAIN 29..218
FT /note="Attacin-B"
FT /id="PRO_0000004896"
FT VARIANT 108
FT /note="A -> D (in strain: 2CPA-7)"
FT VARIANT 138
FT /note="Q -> P (in strain: 2CPA-122)"
FT CONFLICT 154
FT /note="A -> G (in Ref. 3; AAF58214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 22583 MW; 3FA9B53E0C739BCA CRC64;
MQKTSILILA LFAIAEAVPT TGPIRVRRQV LGGSLASNPA GGADARLNLS KGIGNPNHNV
VGQVFAAGNT QSGPVTTGGT LAYNNAGHGA SLTKTHTPGV KDVFQQEAHA NLFNNGRHNL
DAKVFASQNK LANGFEFQRN GAGLDYSHIN GHGASLTHSN FPGIGQQLGL DGRANLWSSP
NRATTLDLTG SASKWTSGPF ANQKPNFGAG LGLSHHFG
