ID   ATTB_HYACE              Reviewed;         233 AA.
AC   P01512;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Attacin-B;
DE   AltName: Full=Immune protein P5;
DE   Flags: Precursor;
OS   Hyalophora cecropia (Cecropia moth) (Samia cecropia).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Attacini; Hyalophora.
OX   NCBI_TaxID=7123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fat body;
RX   PubMed=2406140; DOI=10.1111/j.1432-1033.1990.tb15356.x;
RA   Gunne H., Hellers M., Steiner H.;
RT   "Structure of preproattacin and its processing in insect cells infected
RT   with a recombinant baculovirus.";
RL   Eur. J. Biochem. 187:699-703(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3840100; DOI=10.1016/0145-305x(85)90018-7;
RA   Boman H.G., Faye I., von Hofsten P., Kockum K., Lee J.-Y.,
RA   Xanthopoulos K.G., Bennich H., Engstroem A., Merrifield R.B., Andreu D.;
RT   "On the primary structures of lysozyme, cecropins and attacins from
RT   Hyalophora cecropia.";
RL   Dev. Comp. Immunol. 9:551-558(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2001705; DOI=10.1111/j.1432-1033.1991.tb15811.x;
RA   Sun S.C., Lindstroem I., Lee J.-Y., Faye I.;
RT   "Structure and expression of the attacin genes in Hyalophora cecropia.";
RL   Eur. J. Biochem. 196:247-254(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 11-233.
RX   PubMed=16453548; DOI=10.1002/j.1460-2075.1984.tb02093.x;
RA   Kockum K., Faye I., von Hofsten P., Lee J.-Y., Xanthopoulos K.G.,
RA   Boman H.G.;
RT   "Insect immunity. Isolation and sequence of two cDNA clones corresponding
RT   to acidic and basic attacins from Hyalophora cecropia.";
RL   EMBO J. 3:2071-2075(1984).
CC   -!- FUNCTION: Hemolymph antibacterial protein.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: There are six forms of attacin that are divided into two
CC       groups: acidic (E and F) and basic (A, B, C, and D).
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   EMBL; X17619; CAA35620.1; -; mRNA.
DR   EMBL; X00787; CAA25365.1; -; mRNA.
DR   EMBL; X62290; CAA44179.1; -; Genomic_DNA.
DR   EMBL; M34925; AAA29182.1; -; mRNA.
DR   PIR; S12199; EWWKBC.
DR   AlphaFoldDB; P01512; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR005521; Attacin_C.
DR   InterPro; IPR005520; Attacin_N.
DR   Pfam; PF03769; Attacin_C; 1.
DR   Pfam; PF03768; Attacin_N; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW   Innate immunity; Repeat; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..46
FT                   /id="PRO_0000004900"
FT   CHAIN           47..233
FT                   /note="Attacin-B"
FT                   /id="PRO_0000004901"
FT   CONFLICT        11
FT                   /note="L -> V (in Ref. 4; CAA25365/AAA29182)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        101
FT                   /note="V -> G (in Ref. 3; CAA44179)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   233 AA;  25527 MW;  B55D2273CF9BB57C CRC64;
     MFAKLFLVSV LLVGVNSRYV LVEEPGYYDK QYEEQPQQWV NSRVRRQAGA LTINSDGTSG
     AVVKVPITGN ENHKFSALGS VDLTNQMKLG AATAGLAYDN VNGHGATLTK THIPGFGDKM
     TAAGKVNLFH NDNHDFSAKA FATKNMPNIP QVPNFNTVGA GVDYMFKDKI GASANAAHTD
     FINRNDYSLG GKLNLFKTPT TSLDFNAGWK KFDTPFFKSS WEPSTSFSFS KYF