AB43G_ARATH
ID AB43G_ARATH Reviewed; 1390 AA.
AC Q7PC81; F4JJF5;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=ABC transporter G family member 43;
DE Short=ABC transporter ABCG.43;
DE Short=AtABCG43;
DE AltName: Full=Pleiotropic drug resistance protein 15;
GN Name=ABCG43; Synonyms=PDR15; OrderedLocusNames=At4g15236;
GN ORFNames=FCAALL.461;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RX PubMed=12430018; DOI=10.1007/s00425-002-0889-z;
RA van den Brule S., Smart C.C.;
RT "The plant PDR family of ABC transporters.";
RL Planta 216:95-106(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AL161541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE83574.2; -; Genomic_DNA.
DR EMBL; BK001014; DAA00883.1; -; Genomic_DNA.
DR RefSeq; NP_680694.3; NM_148328.3.
DR AlphaFoldDB; Q7PC81; -.
DR SMR; Q7PC81; -.
DR STRING; 3702.AT4G15236.1; -.
DR iPTMnet; Q7PC81; -.
DR PaxDb; Q7PC81; -.
DR PRIDE; Q7PC81; -.
DR EnsemblPlants; AT4G15236.1; AT4G15236.1; AT4G15236.
DR GeneID; 827189; -.
DR Gramene; AT4G15236.1; AT4G15236.1; AT4G15236.
DR KEGG; ath:AT4G15236; -.
DR Araport; AT4G15236; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q7PC81; -.
DR OMA; FICSFFE; -.
DR OrthoDB; 324553at2759; -.
DR PhylomeDB; Q7PC81; -.
DR PRO; PR:Q7PC81; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q7PC81; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1390
FT /note="ABC transporter G family member 43"
FT /id="PRO_0000234642"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 737..757
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1134..1154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1173..1193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1218..1238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1253..1273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1279..1299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1307..1327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1362..1382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 137..411
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 489..701
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 798..1043
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1115..1329
FT /note="ABC transmembrane type-2 2"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 171..178
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 835..842
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 543
FT /note="L -> M (in Ref. 3; DAA00883)"
SQ SEQUENCE 1390 AA; 157625 MW; 06217E592C5CCCAC CRC64;
MTMPQTDGVE FASRNNLENG DGDQVRSQWV AIERSPTCKR ITTALFCKRD EQGKRSQRRV
MDVSKLEDLD RRLFIDELIR HVEDDNRVLL QKIRTRTDEV GIDLPKIEVR FSDLFVEAEC
EVVHGKPIPT LWNAIASKLS RFTFSKQEDK ISILKGVSGI IRPKRMTLLL GPPGCGKTTL
LLALSGRLDP SLKTRGEVSY NGHLFSEFVP EKTSSYVSQN DLHIPELSVR ETLDFSGCFQ
GAGSRLEMMK EISRREKLKG IVPDPDIDAY MKAASIEGSK TNLQTDYILK ILGLTICADT
RVGDASRPGI SGGQKRRLTT GEMIVGPIKT LFMDEISNGL DSSTTFQILS CLQQFARLSE
GTILVSLLQP APETFELFDD LILMGEGKII YHGPRDFICS FFEDCGFKCP QRKSVAEFLQ
EVISRKDQEQ YWCHRDKPYC YVSIDSFIEK FKKSDLGLQL QDELSKTYDK SQTQKDGLCI
RKYSLSNWDM FKACSRREFL LMKRNSFVYV FKSGLLIFIG SIAMTVYLRT GSTRDSLHAN
YLLGSLFFSL IKLLADGLPE LTLTVSRIAV FCKQKELYFY PAWAYAIPSA ILKIPISFLE
SFLWTMLTYY VIGYSPEAGR FIRQVLILFA LHLSCISMFR AIGAVFRDFD VATTIGSISI
VLLSVFGGFI VRKPSMPSWL EWGFWLSPLS YAEIGLTSNE FFAPMWRKMT SENRTLGEQV
LDARGLNFGN QSYWNAFGAL IGFTLFFNTV FALALTFLKT SQRSRVIVSH DKNTQSSEKD
SKIASHSKNA LPFEPLTFTF QDVQYFIETP QGKKLQLLSD VTGAFKPGVL TALMGVSGAG
KTTLLDVLSG RKTRGDIKGQ IEVGGYVKVQ DTFSRVSGYC EQFDIHSPNL TVQESLKYSA
WLRLPCNISS ETKSAIVNEV LETIELEEIK DSLVGVPGIS GVTAEQRKRL TIAVELVSNP
SIIFMDEPTT GLDARAAAIV MRAVKNIAET GRTVVCTIHQ PSIDIFEAFD ELILMKNGGK
IIYYGPLGQH SSKVIEYFMS IPGVPKLKEN SNPATWILDI TSKSSEDKLG VDLAHIYEES
TLFKENKMVI EQTRCTSLGS ERLILSSRYA QTSWEQFKAC LWKQHLSYWR NPSYNLTRII
FMCFTCMLCG ILFLQKAKEI NNQQDLFNVF GSMFTVVLFS GINNCSTVIF CVATERNVFY
RERFSRMYNP WAYSLAQVLV EIPYSLFQSI IYVIIVYPMV GYHWSVYKVF WSFYSIFCSL
LIFNYFGMLL VVVTPNVHIA FTLRSSFYAI VNLFAGYVMP KPNIPRWWIW MYYLSPTSWV
LNGLLTSQYG DMEKEILAFG EKKKVSAFLE DYFGYRYDSL ALVAVVLIAF PILLASLFAF
FIGKLNFQKK
