RPOC_THEAQ
ID RPOC_THEAQ Reviewed; 1524 AA.
AC Q9KWU6;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=DNA-directed RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE Short=RNAP subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=Transcriptase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
GN Name=rpoC {ECO:0000255|HAMAP-Rule:MF_01322};
OS Thermus aquaticus.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=271;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND X-RAY CRYSTALLOGRAPHY (3.3
RP ANGSTROMS).
RX PubMed=10499798; DOI=10.1016/s0092-8674(00)81515-9;
RA Zhang G., Campbell E.A., Minakhin L., Richter C., Severinov K., Darst S.A.;
RT "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A
RT resolution.";
RL Cell 98:811-824(1999).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01322};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
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DR EMBL; Y19223; CAB65466.3; -; Genomic_DNA.
DR PDB; 1HQM; X-ray; 3.30 A; D=1-1524.
DR PDB; 1I6V; X-ray; 3.30 A; D=1-1524.
DR PDB; 1L9U; X-ray; 4.00 A; D/M=1-1524.
DR PDB; 1L9Z; X-ray; 6.50 A; D=1-1524.
DR PDB; 1YNJ; X-ray; 3.20 A; D/J=1-1524.
DR PDB; 1YNN; X-ray; 3.30 A; D/J=1-1524.
DR PDB; 2AUJ; X-ray; 2.70 A; D=151-455.
DR PDB; 2GHO; X-ray; 5.00 A; D=1-158, D=452-1524.
DR PDB; 4XLN; X-ray; 4.00 A; D/J=1-1524.
DR PDB; 4XLP; X-ray; 4.00 A; D/J=1-1524.
DR PDB; 4XLQ; X-ray; 4.60 A; D/J=1-1524.
DR PDB; 4XLR; X-ray; 4.30 A; D/J=1-1524.
DR PDB; 4XLS; X-ray; 4.01 A; D/J=1-1524.
DR PDB; 5TJG; X-ray; 2.60 A; D=1-1524.
DR PDBsum; 1HQM; -.
DR PDBsum; 1I6V; -.
DR PDBsum; 1L9U; -.
DR PDBsum; 1L9Z; -.
DR PDBsum; 1YNJ; -.
DR PDBsum; 1YNN; -.
DR PDBsum; 2AUJ; -.
DR PDBsum; 2GHO; -.
DR PDBsum; 4XLN; -.
DR PDBsum; 4XLP; -.
DR PDBsum; 4XLQ; -.
DR PDBsum; 4XLR; -.
DR PDBsum; 4XLS; -.
DR PDBsum; 5TJG; -.
DR AlphaFoldDB; Q9KWU6; -.
DR SMR; Q9KWU6; -.
DR PRIDE; Q9KWU6; -.
DR EvolutionaryTrace; Q9KWU6; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.274.100; -; 1.
DR Gene3D; 4.10.860.120; -; 1.
DR HAMAP; MF_01322; RNApol_bact_RpoC; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR012754; DNA-dir_RpoC_beta_prime_bact.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; PTHR19376; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 2.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 2.
DR SMART; SM00663; RPOLA_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-directed RNA polymerase; Magnesium; Metal-binding;
KW Nucleotidyltransferase; Transcription; Transferase; Zinc.
FT CHAIN 1..1524
FT /note="DNA-directed RNA polymerase subunit beta'"
FT /id="PRO_0000067817"
FT REGION 1502..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 58
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 60
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 739
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 741
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 743
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1112
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1194
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1201
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1204
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT STRAND 7..12
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 15..21
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 22..25
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 34..36
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:1YNJ"
FT HELIX 47..50
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 74..76
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 83..87
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 90..100
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 103..106
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 111..116
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 120..127
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 128..131
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 132..136
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 142..146
FT /evidence="ECO:0007829|PDB:1YNJ"
FT HELIX 150..153
FT /evidence="ECO:0007829|PDB:1HQM"
FT HELIX 155..163
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 166..170
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 199..205
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 208..226
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 227..229
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 234..236
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 241..244
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 249..252
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 257..263
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 268..274
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 277..284
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 286..290
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 303..312
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 317..321
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 323..327
FT /evidence="ECO:0007829|PDB:1YNN"
FT STRAND 330..346
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 351..353
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 359..361
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 366..372
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 373..375
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 380..387
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 390..402
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 420..422
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 423..425
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 433..438
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 439..442
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 443..447
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 453..455
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 457..467
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 470..478
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 479..482
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 486..505
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 509..512
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 513..519
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 522..524
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 527..529
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 531..533
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 535..537
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 539..558
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 559..561
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 564..583
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 586..589
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 594..596
FT /evidence="ECO:0007829|PDB:1I6V"
FT HELIX 603..607
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 608..612
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 613..616
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 617..619
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 620..632
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 641..645
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 646..652
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 654..663
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 666..669
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 670..680
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 685..695
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 700..703
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 710..712
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 713..728
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 730..732
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 733..736
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 740..742
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 744..748
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 753..761
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 765..767
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 772..774
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 776..779
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 784..793
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 799..803
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 805..808
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 809..817
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 818..821
FT /evidence="ECO:0007829|PDB:1YNN"
FT STRAND 822..825
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 827..829
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 832..834
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 836..840
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 842..845
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 846..854
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 860..862
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 864..868
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 871..875
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 877..890
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 893..899
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 908..921
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 924..945
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 951..953
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 959..979
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 981..983
FT /evidence="ECO:0007829|PDB:1YNJ"
FT HELIX 985..1014
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1016..1018
FT /evidence="ECO:0007829|PDB:1HQM"
FT HELIX 1019..1025
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1026..1029
FT /evidence="ECO:0007829|PDB:1YNJ"
FT HELIX 1032..1039
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1043..1046
FT /evidence="ECO:0007829|PDB:1YNN"
FT STRAND 1050..1052
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1061..1063
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1067..1083
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1086..1089
FT /evidence="ECO:0007829|PDB:1HQM"
FT STRAND 1090..1092
FT /evidence="ECO:0007829|PDB:1YNJ"
FT HELIX 1094..1102
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1106..1110
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1118..1126
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1129..1134
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1137..1144
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1148..1151
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1153..1155
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1158..1160
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1168..1179
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1184..1189
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1191..1193
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1199..1201
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1202..1204
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1209..1211
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1212..1214
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1221..1230
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1231..1235
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1256..1263
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1269..1271
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1276..1278
FT /evidence="ECO:0007829|PDB:1HQM"
FT STRAND 1279..1284
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1286..1288
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 1290..1295
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1300..1305
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1324..1329
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1332..1339
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1341..1358
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1365..1374
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1378..1383
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1385..1387
FT /evidence="ECO:0007829|PDB:1YNJ"
FT STRAND 1394..1396
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1397..1407
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1408..1411
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1416..1419
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1424..1429
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1430..1432
FT /evidence="ECO:0007829|PDB:1I6V"
FT HELIX 1434..1438
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1443..1453
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1462..1468
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1475..1477
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1479..1483
FT /evidence="ECO:0007829|PDB:5TJG"
FT STRAND 1484..1488
FT /evidence="ECO:0007829|PDB:5TJG"
FT HELIX 1489..1496
FT /evidence="ECO:0007829|PDB:5TJG"
FT TURN 1497..1499
FT /evidence="ECO:0007829|PDB:1YNJ"
SQ SEQUENCE 1524 AA; 170944 MW; 2720C58615070B7B CRC64;
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF GPIKDYECAC
GKYKRQRFEG KVCERCGVEV TRSIVRRYRM GHIELATPAA HIWFVKDVPS KIGTLLDLSA
TELEQVLYFN KYIVLDPKGA VLDGVPVEKR QLLTDEEYRE LRYGKQETYP LPAGVDALVK
DGEEVVKGQE LAPGVVSRMD GVALYRFPRR VRVDYLRKER AALRIPLSAW VEKEAYRPGE
VLAELSEPYL FRAEESGVVE LKDLAEGHLI YLRQEEEVVA RYFLPAGMTP LVVEGEIVEV
GQPLAEGKGL LRLPRHMTAK EVEAEEEGDS VHLTLFLEWT EPKDYKVAPH MNVIVPEGAK
VQAGEKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV YPFEDDVEVT TGDRVAPGDV
LADGGKVKSE IYGRVEVDLV RNVVRVVESY DIDARMGAEA IQELLKELDL EKLERELLEE
MKHPSRARRA KARKRLEVVR AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL
NDLYRRLINR NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA VIDNGRRGSP VTNPGSERPL
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL ELFKPFLLKK
MEEKAFAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV LLNRAPTLHR LGIQAFQPVL
VEGQSIQLHP LVCEAFNADF DGDQMAVHVP LSSFAQAEAR IQMLSAHNLL SPASGEPLAK
PSRDIILGLY YITQVRKEKK GAGMAFATPE EALAAYERGE VALNAPIVVA GRETSVGRLK
FVFANPDEAL LAVAHGLLDL QDVVTVRYLG RRLETSPGRI LFARIVGEAV GDEKVAQELI
QMDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT LSTTSGITIG IDDAVIPEEK
QRYLEEADRK LRQIEQAYEM GFLTDRERYD QVIQLWTETT EKVTQAVFKN FEENYPFNPL
YVMAQSGARG NPQQIRQLCG MRGLMQKPSG ETFEVPVRSS FREGLTVLEY FISSHGARKG
GADTALRTAD SGYLTRKLVD VAHEIVVREA DCGTTNYISV PLFQMDEVTR TLRLRKRSDI
ESGLYGRVLA REVEALGRRL EEGRYLSLED VHFLIKAAEA GEVREVPVRS PLTCQTRYGV
CQKCYGYDLS MARPVSIGEA VGVVAAESIG EPGTQLTMRT FHTGGVAVGT DITQGLPRVI
ELFEARRPKA KAVISEIDGV VRIEEGEDRL SVFVESEGFS KEYKLPKDAR LLVKDGDYVE
AGQPLTRGAI DPHQLLEAKG PEAVERYLVD EIQKVYRAQG VKLHDKHIEI VVRQMLKYVE
VTDPGDSRLL EGQVLEKWDV EALNERLIAE GKVPVAWKPL LMGVTKSALS TKSWLSAASF
QNTTHVLTEA AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQR TLKAIEEARK
EAVEAKEKEA PRRPVRREQP GKGL
