RPOC_THET8
ID RPOC_THET8 Reviewed; 1524 AA.
AC Q8RQE8; Q5SHB8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=DNA-directed RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE Short=RNAP subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE AltName: Full=Transcriptase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
GN Name=rpoC {ECO:0000255|HAMAP-Rule:MF_01322}; OrderedLocusNames=TTHA1812;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12198314; DOI=10.1107/s0907444902011770;
RA Vassylyeva M.N., Lee J., Sekine S.I., Laptenko O., Kuramitsu S.,
RA Shibata T., Inoue Y., Borukhov S., Vassylyev D.G., Yokoyama S.;
RT "Purification, crystallization and initial crystallographic analysis of RNA
RT polymerase holoenzyme from Thermus thermophilus.";
RL Acta Crystallogr. D 58:1497-1500(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01322};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01322};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01322};
CC -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC and 1 omega subunit. When a sigma factor is associated with the core
CC the holoenzyme is formed, which can initiate transcription.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
CC -!- INTERACTION:
CC Q8RQE8; Q5SHR6: rpoA; NbExp=4; IntAct=EBI-2106930, EBI-2106870;
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000255|HAMAP-Rule:MF_01322}.
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DR EMBL; AB083790; BAB89401.1; -; Genomic_DNA.
DR EMBL; AP008226; BAD71635.1; -; Genomic_DNA.
DR RefSeq; WP_011228934.1; NC_006461.1.
DR RefSeq; YP_145078.1; NC_006461.1.
DR PDB; 1IW7; X-ray; 2.60 A; D/N=1-1524.
DR PDB; 1SMY; X-ray; 2.70 A; D/N=1-1524.
DR PDB; 1ZYR; X-ray; 3.00 A; D/N=1-1524.
DR PDB; 2A68; X-ray; 2.50 A; D/N=1-1524.
DR PDB; 2A69; X-ray; 2.50 A; D/N=1-1524.
DR PDB; 2A6E; X-ray; 2.80 A; D/N=1-1524.
DR PDB; 2A6H; X-ray; 2.40 A; D/N=1-1524.
DR PDB; 2BE5; X-ray; 2.40 A; D/N=1-1524.
DR PDB; 2CW0; X-ray; 3.30 A; D/N=1-1524.
DR PDB; 2O5I; X-ray; 2.50 A; D/N=1-1524.
DR PDB; 2O5J; X-ray; 3.00 A; D/N=1-1524.
DR PDB; 2PPB; X-ray; 3.00 A; D/N=1-1524.
DR PDB; 3AOH; X-ray; 4.10 A; D/I/N=1-1524.
DR PDB; 3AOI; X-ray; 4.30 A; D/I/N=1-1524.
DR PDB; 3DXJ; X-ray; 3.00 A; D/N=1-1524.
DR PDB; 3EQL; X-ray; 2.70 A; D/N=1-1524.
DR PDB; 3WOD; X-ray; 3.60 A; D=1-1524.
DR PDB; 4G7H; X-ray; 2.90 A; D/N=1-1524.
DR PDB; 4G7O; X-ray; 2.99 A; D/N=1-1524.
DR PDB; 4G7Z; X-ray; 3.82 A; D/N=1-1524.
DR PDB; 4GZY; X-ray; 3.51 A; D=1-1524.
DR PDB; 4GZZ; X-ray; 4.29 A; D=1-1524.
DR PDB; 4MQ9; X-ray; 3.35 A; D=1-1524.
DR PDB; 4OIN; X-ray; 2.80 A; D=1-1524.
DR PDB; 4OIO; X-ray; 3.10 A; D=1-1524.
DR PDB; 4OIP; X-ray; 3.40 A; D=1-1524.
DR PDB; 4OIQ; X-ray; 3.62 A; D=1-1524.
DR PDB; 4OIR; X-ray; 3.10 A; D=1-1524.
DR PDB; 4Q4Z; X-ray; 2.90 A; D=1-1524.
DR PDB; 4Q5S; X-ray; 3.00 A; D=1-1524.
DR PDB; 4WQS; X-ray; 4.31 A; D/N=1-1524.
DR PDB; 4WQT; X-ray; 4.40 A; D/I/N=1-1524.
DR PDB; 5D4C; X-ray; 3.28 A; D/N=1-1524.
DR PDB; 5D4D; X-ray; 3.00 A; D/N=1-1524.
DR PDB; 5D4E; X-ray; 3.08 A; D/N=1-1524.
DR PDB; 5E17; X-ray; 3.20 A; D=1-1524.
DR PDB; 5E18; X-ray; 3.30 A; D=1-1524.
DR PDB; 5I2D; X-ray; 4.41 A; D/O=1-1524.
DR PDB; 5TMC; X-ray; 2.71 A; D=1-1524.
DR PDB; 5TMF; X-ray; 3.00 A; D=1-1524.
DR PDB; 5VO8; X-ray; 3.30 A; D=1-1524.
DR PDB; 5VOI; X-ray; 2.80 A; D=1-1524.
DR PDB; 5X21; X-ray; 3.32 A; D=1-1524.
DR PDB; 5X22; X-ray; 3.35 A; D/N=1-1524.
DR PDB; 5XJ0; X-ray; 4.00 A; D=1-1524.
DR PDB; 6ASG; X-ray; 3.80 A; D=1-1524.
DR PDB; 6KQD; X-ray; 3.30 A; D/N=1-1524.
DR PDB; 6KQE; X-ray; 3.30 A; D=1-1524.
DR PDB; 6KQF; X-ray; 2.45 A; D=1-1524.
DR PDB; 6KQG; X-ray; 2.78 A; D=1-1524.
DR PDB; 6KQH; X-ray; 3.18 A; D=1-1524.
DR PDB; 6KQL; X-ray; 2.89 A; D=1-1524.
DR PDB; 6KQM; X-ray; 3.20 A; D=1-1524.
DR PDB; 6KQN; X-ray; 3.49 A; D=1-1524.
DR PDB; 6L74; X-ray; 3.12 A; D=1-1524.
DR PDB; 6LTS; X-ray; 3.45 A; D=1-1524.
DR PDB; 6M6A; EM; 5.00 A; D=1-1524.
DR PDB; 6M6B; EM; 4.10 A; D=1-1524.
DR PDB; 6M6C; EM; 3.10 A; D=1-1524.
DR PDB; 6OVR; X-ray; 2.84 A; D=1-1524.
DR PDB; 6OVY; X-ray; 3.00 A; D=1-1524.
DR PDB; 6OW3; X-ray; 2.77 A; D=1-1524.
DR PDB; 6OY5; X-ray; 3.10 A; D=1-1524.
DR PDB; 6OY6; X-ray; 3.10 A; D=1-1502.
DR PDB; 6OY7; X-ray; 3.04 A; D=1-1524.
DR PDB; 6P70; X-ray; 3.05 A; D=1-1524.
DR PDB; 6P71; X-ray; 2.92 A; D=1-1524.
DR PDB; 6WOX; X-ray; 3.14 A; D=1-1505.
DR PDB; 6WOY; X-ray; 3.00 A; D=1-1505.
DR PDB; 7EH0; X-ray; 2.81 A; D=1-1524.
DR PDB; 7EH1; X-ray; 2.90 A; D=1-1524.
DR PDB; 7EH2; X-ray; 3.34 A; D/N=1-1524.
DR PDB; 7MLB; X-ray; 3.60 A; D=1-1524.
DR PDB; 7MLI; X-ray; 3.60 A; D=1-1524.
DR PDB; 7MLJ; X-ray; 3.75 A; D=1-1524.
DR PDB; 7RDQ; EM; 3.00 A; D=1-1524.
DR PDBsum; 1IW7; -.
DR PDBsum; 1SMY; -.
DR PDBsum; 1ZYR; -.
DR PDBsum; 2A68; -.
DR PDBsum; 2A69; -.
DR PDBsum; 2A6E; -.
DR PDBsum; 2A6H; -.
DR PDBsum; 2BE5; -.
DR PDBsum; 2CW0; -.
DR PDBsum; 2O5I; -.
DR PDBsum; 2O5J; -.
DR PDBsum; 2PPB; -.
DR PDBsum; 3AOH; -.
DR PDBsum; 3AOI; -.
DR PDBsum; 3DXJ; -.
DR PDBsum; 3EQL; -.
DR PDBsum; 3WOD; -.
DR PDBsum; 4G7H; -.
DR PDBsum; 4G7O; -.
DR PDBsum; 4G7Z; -.
DR PDBsum; 4GZY; -.
DR PDBsum; 4GZZ; -.
DR PDBsum; 4MQ9; -.
DR PDBsum; 4OIN; -.
DR PDBsum; 4OIO; -.
DR PDBsum; 4OIP; -.
DR PDBsum; 4OIQ; -.
DR PDBsum; 4OIR; -.
DR PDBsum; 4Q4Z; -.
DR PDBsum; 4Q5S; -.
DR PDBsum; 4WQS; -.
DR PDBsum; 4WQT; -.
DR PDBsum; 5D4C; -.
DR PDBsum; 5D4D; -.
DR PDBsum; 5D4E; -.
DR PDBsum; 5E17; -.
DR PDBsum; 5E18; -.
DR PDBsum; 5I2D; -.
DR PDBsum; 5TMC; -.
DR PDBsum; 5TMF; -.
DR PDBsum; 5VO8; -.
DR PDBsum; 5VOI; -.
DR PDBsum; 5X21; -.
DR PDBsum; 5X22; -.
DR PDBsum; 5XJ0; -.
DR PDBsum; 6ASG; -.
DR PDBsum; 6KQD; -.
DR PDBsum; 6KQE; -.
DR PDBsum; 6KQF; -.
DR PDBsum; 6KQG; -.
DR PDBsum; 6KQH; -.
DR PDBsum; 6KQL; -.
DR PDBsum; 6KQM; -.
DR PDBsum; 6KQN; -.
DR PDBsum; 6L74; -.
DR PDBsum; 6LTS; -.
DR PDBsum; 6M6A; -.
DR PDBsum; 6M6B; -.
DR PDBsum; 6M6C; -.
DR PDBsum; 6OVR; -.
DR PDBsum; 6OVY; -.
DR PDBsum; 6OW3; -.
DR PDBsum; 6OY5; -.
DR PDBsum; 6OY6; -.
DR PDBsum; 6OY7; -.
DR PDBsum; 6P70; -.
DR PDBsum; 6P71; -.
DR PDBsum; 6WOX; -.
DR PDBsum; 6WOY; -.
DR PDBsum; 7EH0; -.
DR PDBsum; 7EH1; -.
DR PDBsum; 7EH2; -.
DR PDBsum; 7MLB; -.
DR PDBsum; 7MLI; -.
DR PDBsum; 7MLJ; -.
DR PDBsum; 7RDQ; -.
DR AlphaFoldDB; Q8RQE8; -.
DR SMR; Q8RQE8; -.
DR DIP; DIP-47007N; -.
DR IntAct; Q8RQE8; 5.
DR STRING; 300852.55773194; -.
DR DrugBank; DB08266; Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate.
DR DrugBank; DB08226; Myxopyronin B.
DR DrugBank; DB04788; Tagetitoxin.
DR EnsemblBacteria; BAD71635; BAD71635; BAD71635.
DR GeneID; 3169754; -.
DR KEGG; ttj:TTHA1812; -.
DR PATRIC; fig|300852.9.peg.1783; -.
DR eggNOG; COG0086; Bacteria.
DR HOGENOM; CLU_000524_3_1_0; -.
DR OMA; YRNIRVE; -.
DR PhylomeDB; Q8RQE8; -.
DR BRENDA; 2.7.7.6; 2305.
DR EvolutionaryTrace; Q8RQE8; -.
DR PRO; PR:Q8RQE8; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.274.100; -; 1.
DR Gene3D; 4.10.860.120; -; 1.
DR HAMAP; MF_01322; RNApol_bact_RpoC; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR012754; DNA-dir_RpoC_beta_prime_bact.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; PTHR19376; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 2.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 2.
DR SMART; SM00663; RPOLA_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-directed RNA polymerase; Magnesium; Metal-binding;
KW Nucleotidyltransferase; Reference proteome; Transcription; Transferase;
KW Zinc.
FT CHAIN 1..1524
FT /note="DNA-directed RNA polymerase subunit beta'"
FT /id="PRO_0000067820"
FT REGION 1500..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 58
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 60
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 739
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 741
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 743
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1112
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1194
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1201
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT BINDING 1204
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01322"
FT STRAND 7..11
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 15..21
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 22..25
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 34..36
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 47..50
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:6KQF"
FT TURN 67..70
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 74..76
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:2PPB"
FT HELIX 84..88
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 90..100
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 102..105
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 106..109
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 111..115
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 122..129
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 133..135
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 155..162
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 166..170
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 177..186
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 187..189
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 195..197
FT /evidence="ECO:0007829|PDB:1ZYR"
FT STRAND 199..201
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 204..206
FT /evidence="ECO:0007829|PDB:2O5I"
FT STRAND 207..209
FT /evidence="ECO:0007829|PDB:2BE5"
FT STRAND 211..213
FT /evidence="ECO:0007829|PDB:1SMY"
FT STRAND 217..222
FT /evidence="ECO:0007829|PDB:3DXJ"
FT TURN 226..231
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 233..236
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 237..239
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 241..244
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 245..247
FT /evidence="ECO:0007829|PDB:1ZYR"
FT HELIX 248..250
FT /evidence="ECO:0007829|PDB:2BE5"
FT STRAND 257..263
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 265..274
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 277..284
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 286..290
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 297..300
FT /evidence="ECO:0007829|PDB:3DXJ"
FT STRAND 303..312
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 317..327
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 330..346
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 359..361
FT /evidence="ECO:0007829|PDB:4G7O"
FT STRAND 366..369
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 373..375
FT /evidence="ECO:0007829|PDB:6KQF"
FT TURN 378..381
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 383..387
FT /evidence="ECO:0007829|PDB:5TMC"
FT STRAND 391..394
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 396..401
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 407..409
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 415..417
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 420..422
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 423..425
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 427..429
FT /evidence="ECO:0007829|PDB:5TMC"
FT STRAND 434..438
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 439..442
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 443..447
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 453..455
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 458..467
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 470..482
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 486..504
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 509..512
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 513..519
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 522..524
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 527..529
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 531..533
FT /evidence="ECO:0007829|PDB:5TMC"
FT STRAND 535..537
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 540..560
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 564..582
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 584..588
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 593..595
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 596..599
FT /evidence="ECO:0007829|PDB:2O5J"
FT HELIX 603..607
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 609..611
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 613..619
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 621..633
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 635..637
FT /evidence="ECO:0007829|PDB:4OIO"
FT STRAND 641..645
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 646..652
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 654..663
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 664..666
FT /evidence="ECO:0007829|PDB:2O5I"
FT STRAND 667..669
FT /evidence="ECO:0007829|PDB:6P71"
FT HELIX 670..677
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 680..682
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 685..694
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 695..697
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 700..703
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 710..712
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 713..724
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 726..728
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 731..733
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 734..737
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 740..742
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 744..748
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 753..762
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 765..767
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 772..779
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 783..793
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 799..801
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 805..808
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 810..821
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 823..825
FT /evidence="ECO:0007829|PDB:4OIO"
FT STRAND 827..834
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 836..840
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 842..845
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 846..854
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 860..862
FT /evidence="ECO:0007829|PDB:5TMC"
FT STRAND 865..867
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 871..875
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 877..889
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 893..898
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 902..904
FT /evidence="ECO:0007829|PDB:6KQH"
FT HELIX 908..921
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 924..945
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 951..953
FT /evidence="ECO:0007829|PDB:6KQF"
FT HELIX 960..979
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 980..983
FT /evidence="ECO:0007829|PDB:1ZYR"
FT HELIX 985..1013
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1019..1025
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1026..1029
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1032..1038
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1043..1046
FT /evidence="ECO:0007829|PDB:6P71"
FT STRAND 1048..1050
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1052..1057
FT /evidence="ECO:0007829|PDB:6P71"
FT STRAND 1061..1063
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1068..1102
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1106..1110
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 1118..1123
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1127..1130
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1132..1134
FT /evidence="ECO:0007829|PDB:6KQG"
FT HELIX 1137..1144
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1148..1151
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1153..1155
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 1158..1160
FT /evidence="ECO:0007829|PDB:6KQF"
FT TURN 1168..1172
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1173..1180
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1184..1188
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1191..1193
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1197..1200
FT /evidence="ECO:0007829|PDB:2BE5"
FT HELIX 1202..1205
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1209..1214
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1221..1230
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1232..1234
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 1239..1243
FT /evidence="ECO:0007829|PDB:6P71"
FT STRAND 1246..1248
FT /evidence="ECO:0007829|PDB:2BE5"
FT HELIX 1256..1263
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1269..1271
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1279..1283
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1290..1295
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1300..1305
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1311..1313
FT /evidence="ECO:0007829|PDB:6L74"
FT STRAND 1317..1319
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1324..1329
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1332..1339
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1341..1357
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 1358..1360
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1365..1374
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1377..1383
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1385..1387
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1392..1394
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1395..1406
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 1409..1411
FT /evidence="ECO:0007829|PDB:6KQF"
FT STRAND 1416..1419
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1424..1429
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1434..1439
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1443..1452
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1455..1458
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1462..1467
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1473..1475
FT /evidence="ECO:0007829|PDB:2A6H"
FT TURN 1479..1481
FT /evidence="ECO:0007829|PDB:2A6H"
FT STRAND 1485..1487
FT /evidence="ECO:0007829|PDB:2A6H"
FT HELIX 1489..1500
FT /evidence="ECO:0007829|PDB:2A6H"
SQ SEQUENCE 1524 AA; 170756 MW; A7B335945B08E3A7 CRC64;
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF GPIKDYECAC
GKYKRQRFEG KVCERCGVEV TKSIVRRYRM GHIELATPAA HIWFVKDVPS KIGTLLDLSA
TELEQVLYFS KYIVLDPKGA ILNGVPVEKR QLLTDEEYRE LRYGKQETYP LPPGVDALVK
DGEEVVKGQE LAPGVVSRLD GVALYRFPRR VRVEYVKKER AGLRLPLAAW VEKEAYKPGE
ILAELPEPYL FRAEEEGVVE LKELEEGAFL VLRREDEPVA TYFLPVGMTP LVVHGEIVEK
GQPLAEAKGL LRMPRQVRAA QVEAEEEGET VYLTLFLEWT EPKDYRVQPH MNVVVPEGAR
VEAGDKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV YPFEDDVEVS TGDRVAPGDV
LADGGKVKSD VYGRVEVDLV RNVVRVVESY DIDARMGAEA IQQLLKELDL EALEKELLEE
MKHPSRARRA KARKRLEVVR AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL
NDLYRRLINR NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA LLDNGRRGAP VTNPGSDRPL
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL ELFKPFLLKK
MEEKGIAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV LLNRAPTLHR LGIQAFQPVL
VEGQSIQLHP LVCEAFNADF DGDQMAVHVP LSSFAQAEAR IQMLSAHNLL SPASGEPLAK
PSRDIILGLY YITQVRKEKK GAGLEFATPE EALAAHERGE VALNAPIKVA GRETSVGRLK
YVFANPDEAL LAVAHGIVDL QDVVTVRYMG KRLETSPGRI LFARIVAEAV EDEKVAWELI
QLDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT FSTTSGITIG IDDAVIPEEK
KQYLEEADRK LLQIEQAYEM GFLTDRERYD QILQLWTETT EKVTQAVFKN FEENYPFNPL
YVMAQSGARG NPQQIRQLCG LRGLMQKPSG ETFEVPVRSS FREGLTVLEY FISSHGARKG
GADTALRTAD SGYLTRKLVD VTHEIVVREA DCGTTNYISV PLFQPDEVTR SLRLRKRADI
EAGLYGRVLA REVEVLGVRL EEGRYLSMDD VHLLIKAAEA GEIQEVPVRS PLTCQTRYGV
CQKCYGYDLS MARPVSIGEA VGIVAAQSIG EPGTQLTMRT FHTGGVAGAA DITQGLPRVI
ELFEARRPKA KAVISEIDGV VRIEETEEKL SVFVESEGFS KEYKLPKEAR LLVKDGDYVE
AGQPLTRGAI DPHQLLEAKG PEAVERYLVE EIQKVYRAQG VKLHDKHIEI VVRQMMKYVE
VTDPGDSRLL EGQVLEKWDV EALNERLIAE GKTPVAWKPL LMGVTKSALS TKSWLSAASF
QNTTHVLTEA AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQK TLKAIEEARK
EAVEAKERPA ARRGVKREQP GKQA
