AB43G_ORYSJ
ID AB43G_ORYSJ Reviewed; 1454 AA.
AC Q8GU86; A0A0P0X6G5; Q0D5Z6; Q84ZQ8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=ABC transporter G family member 43 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG43 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 5 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR5 {ECO:0000303|PubMed:16506311};
GN Name=ABCG43 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR5 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os07g0522500 {ECO:0000312|EMBL:BAF21727.1},
GN LOC_Os07g33780 {ECO:0000305};
GN ORFNames=OJ1372_D12.114 {ECO:0000312|EMBL:BAC79614.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 958-1454.
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY CADMIUM.
RX PubMed=21670506; DOI=10.1271/bbb.110193;
RA Oda K., Otani M., Uraguchi S., Akihiro T., Fujiwara T.;
RT "Rice ABCG43 is Cd inducible and confers Cd tolerance on yeast.";
RL Biosci. Biotechnol. Biochem. 75:1211-1213(2011).
CC -!- FUNCTION: May be a general defense protein (By similarity). ABC
CC transporter that confers high tolerance to cadmium in yeast
CC (PubMed:21670506). {ECO:0000250, ECO:0000269|PubMed:21670506}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and shoots.
CC {ECO:0000269|PubMed:21670506}.
CC -!- INDUCTION: Induced by cadmium in roots, but not in shoots.
CC {ECO:0000269|PubMed:21670506}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF21727.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAT01819.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD59572.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ535050; CAD59572.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP003827; BAC79614.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21727.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014963; BAT01819.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK105311; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015646575.1; XM_015791089.1.
DR AlphaFoldDB; Q8GU86; -.
DR SMR; Q8GU86; -.
DR STRING; 4530.OS07T0522500-01; -.
DR PRIDE; Q8GU86; -.
DR GeneID; 4343412; -.
DR KEGG; osa:4343412; -.
DR eggNOG; KOG0065; Eukaryota.
DR InParanoid; Q8GU86; -.
DR OrthoDB; 324553at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; Q8GU86; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1454
FT /note="ABC transporter G family member 43"
FT /id="PRO_0000234647"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 659..679
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 775..795
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1196..1216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1236..1256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1284..1304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1314..1334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1341..1361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1372..1392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1423..1443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 170..444
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 522..735
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 852..1104
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1177..1391
FT /note="ABC transmembrane type-2 2"
FT REGION 23..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 204..211
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 897..904
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1454 AA; 163900 MW; 5F4389855EBD4E44 CRC64;
MAGEITPSGS RRSWLSSGAA SLARSLRDGD DPFRRSAAAS RRDAGDDEEN LRWAALEKLP
TYDRMRRGIL RKAVDGGGDG EGAGSLFKAD EVDIANLDPR EGRELMERVF KAVEDDNERF
LRRFRDRLDQ VGIELPKIEV RYQHLDIEAD VHVGKRALPT LLNATINTLE GLVSLFISSN
KRKLKILNDV NGIIKPSRMT LLLGPPSSGK STLMRALTGK PDKNLKVSGE ITYCGHTFKE
FYPERTSAYV SQHDLHNPEM TVRETLDFSR RCLGSGARYD MLSELTRRER NAGIKPDPEI
DALMKATVVE GKQNNIVTDL VLKALGLDIC ADTIVGGAMI RGISGGQKKR VTTGEMLTGP
ATALFMDEIS TGLDSSSTFQ IVKYIRQVTH VMNATVMMSL LQPPPETYAL FDDIVLIAEG
YIVYHGPREN ILEFFESAGF RCPERKGVAD FLQEVTSRKD QQQYWFLEQD HYRYVSVEEF
AQNFKKFHVG QKLQKELQVP YDKSKTHPAA LTTKKYGLSS LESLKAVMSR EWLLMKRNSF
LFIFKAFQLF VLGFITMTLF LRTKMPHEKF SDTSKYVGAL TASLITIMFN GFGELQLTID
KLPIFYKQRD FLFFPAWTYG LANIILKVPL SLMESSLWIV LTYYVVGFAP AAGRFFKQFL
AYFWTHQMAL ALFRLLGAIL RSMVVANTFG MFVLLLIFLF GGFLVSRKDI KPWWIWGYWT
SPMMYSNNAL SVNEFLASRW AIPNNDSSIS APTIGKAFLQ SKGYFTGEWG YWLSIGAMIG
FMIVFNILYL CALTFLRPIG SASTVVSDDD TKSELEAESN QEQMSEVING TNGTENRRSQ
RGMVLPFQPL SLSFNHMNYY VDMPAEMKAQ GFTESRLQLL SDISGAFRPG VLTALVGVSG
AGKTTLMDVL AGRKTSGTIE GDIKLSGYPK KQETFARISG YCEQTDIHSP NLTVYESIVY
SAWLRLSSEV DKNTRKVFVE EVMSLVELDV LRDALVGLPG VSGLSTEQRK RLTIAVELVA
NPSIIFMDEP TSGLDARAAA IVMRTVRNTV NTGRTVVCTI HQPSIDIFES FDELLLLKRG
GRVIYAGQLG LHSQILVEYF EAIPGVPKIT EGYNPATWML EVSSSLAEAR LDIDFAEVYA
NSALYRSNQE LIKQLSVPPP GFQDLSFPTK YSQNFLNQCV ANTWKQFQSY WKDPPYNAMR
YVMTLLYGLV FGTVFWRRGK NIESVNDLNN LLGATYAAVF FLGAANLLTL LPVVSVERTV
FYREKAAGMY SPLSYAFAQG FVEFCYSAVQ GVLYTILIYS MIGYEWKADK FFYFLFFMIA
AFAYFTLFSM MLVACTASEM LAAVLVSFVL SSWNNFAGFI IPRPLIPVWW RWFYWANPVS
WTIYGVIASQ FADSDRVVTV PGQSTTMVVK DFLEKNMGFK HDFLGYVVLA HFGYVIIFFF
LFGYGIKCLN FQKR
