ID   ATT_BOMMO               Reviewed;         214 AA.
AC   Q26431; Q17210;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Attacin;
DE   AltName: Full=Nuecin;
DE   Flags: Precursor;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=106 X Daizo, and Tokai X Asahi; TISSUE=Fat body;
RX   PubMed=7773256; DOI=10.1016/0965-1748(94)00080-2;
RA   Sugiyama M., Kuniyoshi H., Kotani E., Taniai K., Kadono-Okuda K., Kato Y.,
RA   Yamamoto M., Shimabukuro M., Chowdhury S., Xu J.;
RT   "Characterization of a Bombyx mori cDNA encoding a novel member of the
RT   attacin family of insect antibacterial proteins.";
RL   Insect Biochem. Mol. Biol. 25:385-392(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Yun E.Y., Kim S.H., Kang S.W., Jin B.R., Kim K.Y., Kim H.R., Lim S.H.,
RA   Han M.S., Kang S.K.;
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-78.
RC   STRAIN=Tokai X Asahi; TISSUE=Fat body;
RX   PubMed=8607809; DOI=10.1006/bbrc.1996.0448;
RA   Taniai K., Ishii T., Sugiyama M., Miyanoshita A., Yamakawa M.;
RT   "Nucleotide sequence of 5'-upstream region and expression of a silkworm
RT   gene encoding a new member of the attacin family.";
RL   Biochem. Biophys. Res. Commun. 220:594-599(1996).
CC   -!- FUNCTION: Hemolymph antibacterial protein. Has a wide spectrum of
CC       activity against both Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highest expression in fat body and hemocytes and to
CC       a much lesser extent in Malpighian tubules, silk gland and midgut.
CC   -!- INDUCTION: By bacterial infection.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   EMBL; S78369; AAB34519.1; -; mRNA.
DR   EMBL; AF005384; AAB61751.1; -; mRNA.
DR   EMBL; D76418; BAA11173.1; -; Genomic_DNA.
DR   RefSeq; NP_001037006.1; NM_001043541.1.
DR   AlphaFoldDB; Q26431; -.
DR   STRING; 7091.BGIBMGA002747-TA; -.
DR   GeneID; 692555; -.
DR   KEGG; bmor:692555; -.
DR   CTD; 692555; -.
DR   eggNOG; ENOG502SZ31; Eukaryota.
DR   HOGENOM; CLU_1148183_0_0_1; -.
DR   OrthoDB; 1395972at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR005521; Attacin_C.
DR   InterPro; IPR005520; Attacin_N.
DR   Pfam; PF03769; Attacin_C; 1.
DR   Pfam; PF03768; Attacin_N; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..26
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004891"
FT   CHAIN           27..214
FT                   /note="Attacin"
FT                   /id="PRO_0000004892"
SQ   SEQUENCE   214 AA;  22556 MW;  0E98FEE659DB94A4 CRC64;
     MSKSVALLLL CACLASGRHV PTRARRQAGS FTVNSDGTSG AALKVPLTGN DKNVLSAIGS
     ADFNDRHKLS AASAGLALDN VNGHGLSLTG TRIPGFGEQL GVAGKVNLFH NNNHDLSAKA
     FAIRNSPSAI PNAPNFNTLG GGVDYMFKQK VGASLSAAHS DVINRNDYSA GGKLNLFRSP
     SSSLDFNAGF KKFDTPFYRS SWEPNVGFSF SKFF