ID   RPOD_RICBR              Reviewed;         641 AA.
AC   Q1RKH7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=RNA polymerase sigma factor RpoD {ECO:0000255|HAMAP-Rule:MF_00963};
DE   AltName: Full=Sigma-70 {ECO:0000255|HAMAP-Rule:MF_00963};
GN   Name=rpoD {ECO:0000255|HAMAP-Rule:MF_00963}; OrderedLocusNames=RBE_0056;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. This sigma factor is the primary sigma factor during
CC       exponential growth. {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
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DR   EMBL; CP000087; ABE04137.1; -; Genomic_DNA.
DR   RefSeq; WP_011476752.1; NC_007940.1.
DR   AlphaFoldDB; Q1RKH7; -.
DR   SMR; Q1RKH7; -.
DR   STRING; 336407.RBE_0056; -.
DR   PRIDE; Q1RKH7; -.
DR   EnsemblBacteria; ABE04137; ABE04137; RBE_0056.
DR   KEGG; rbe:RBE_0056; -.
DR   eggNOG; COG0568; Bacteria.
DR   HOGENOM; CLU_014793_7_1_5; -.
DR   OMA; HDSIWEM; -.
DR   OrthoDB; 1565734at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 1.10.220.120; -; 1.
DR   HAMAP; MF_00963; Sigma70_RpoD_SigA; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR007631; RNA_pol_sigma_70_non-ess.
DR   InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR   InterPro; IPR042189; RNA_pol_sigma_70_r1_1_sf.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR012760; RNA_pol_sigma_RpoD_C.
DR   InterPro; IPR028630; Sigma70_RpoD.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04546; Sigma70_ner; 1.
DR   Pfam; PF03979; Sigma70_r1_1; 1.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02393; RpoD_Cterm; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..641
FT                   /note="RNA polymerase sigma factor RpoD"
FT                   /id="PRO_0000286504"
FT   DNA_BIND        587..606
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          178..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..462
FT                   /note="Sigma-70 factor domain-2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          471..548
FT                   /note="Sigma-70 factor domain-3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          561..614
FT                   /note="Sigma-70 factor domain-4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          615..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           416..419
FT                   /note="Interaction with polymerase core subunit RpoC"
FT   COMPBIAS        194..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  73734 MW;  22CB3B3976E2FBD2 CRC64;
     MTNTDNNNLN KIDSLLKKAK SKKGSVTYND INRALPDGTS VEEIDKVMFR FSEAEVDILD
     TNEDDAIKID DMEMEEGFKI STNIDHEPED ETEEENIGTT DDPVRLYLKD MGGVDLLTRE
     NEVEIAKRIE EGRKTLIAAL CRSPIAMDKF RKWYADLVNE NNMLLRDLID LESNMMHDDE
     TSESEDDHNS DHEEEEQDHD HDHEENILSM SKVETQILPN IIERMKKIAF ICEELLIETK
     KSFEKSAGPK ILQNSKKYND NLELLISEVS EIHFNSKRTE EILSEMYRIN RDLINKETAF
     LKLAEKYGIT RQNFLDEYIG AVINAAWKEK MLKNKKAGWK ELLTKESDYI DQMIAELSAI
     EINTGLLVND FKKLVNAIQK SERQTLQAKK DMIEANLRLV ISIAKKYANR GLQFLDLIQE
     GNIGLMKAVD KFEYRRGYKF STYATWWIRQ AITRAIADQA RTIRIPVHMI ETINKIIRTS
     RQMLNELGYE PTPAEIAARL SMPIDKVRKV MKIAKEPISL ENPVGDGDDN SYLGDFIEDK
     NAVAPIDAAI QSNLREVTTR VLATLTPREE RVLRMRFGIG MNTDHTLEEV GQQFKVTRER
     IRQIESKALR KLQHPIRSKK LNSFRSGGKR GDGNPSDLLE A