ID   RPOD_RICCN              Reviewed;         634 AA.
AC   Q92FZ8;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=RNA polymerase sigma factor RpoD {ECO:0000255|HAMAP-Rule:MF_00963};
DE   AltName: Full=Sigma-70 {ECO:0000255|HAMAP-Rule:MF_00963};
GN   Name=rpoD {ECO:0000255|HAMAP-Rule:MF_00963}; OrderedLocusNames=RC1329;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. This sigma factor is the primary sigma factor during
CC       exponential growth. {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
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DR   EMBL; AE006914; AAL03867.1; -; Genomic_DNA.
DR   PIR; A97866; A97866.
DR   RefSeq; WP_010977884.1; NC_003103.1.
DR   AlphaFoldDB; Q92FZ8; -.
DR   SMR; Q92FZ8; -.
DR   EnsemblBacteria; AAL03867; AAL03867; RC1329.
DR   KEGG; rco:RC1329; -.
DR   PATRIC; fig|272944.4.peg.1523; -.
DR   HOGENOM; CLU_014793_7_1_5; -.
DR   OMA; HDSIWEM; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 1.10.220.120; -; 1.
DR   HAMAP; MF_00963; Sigma70_RpoD_SigA; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR007631; RNA_pol_sigma_70_non-ess.
DR   InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR   InterPro; IPR042189; RNA_pol_sigma_70_r1_1_sf.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR012760; RNA_pol_sigma_RpoD_C.
DR   InterPro; IPR028630; Sigma70_RpoD.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04546; Sigma70_ner; 1.
DR   Pfam; PF03979; Sigma70_r1_1; 1.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02393; RpoD_Cterm; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..634
FT                   /note="RNA polymerase sigma factor RpoD"
FT                   /id="PRO_0000093910"
FT   DNA_BIND        580..599
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          177..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..455
FT                   /note="Sigma-70 factor domain-2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          464..541
FT                   /note="Sigma-70 factor domain-3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          554..607
FT                   /note="Sigma-70 factor domain-4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          608..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           409..412
FT                   /note="Interaction with polymerase core subunit RpoC"
SQ   SEQUENCE   634 AA;  72831 MW;  BCBD6EC3FD465A84 CRC64;
     MSNSNIDNDL DKIDSLLKKA KSKKIPVTYD DINNALPLNK NPSIRQLEEA ILKFSDAGVD
     ILESNEDDEI KLDIGMDEEF KLSTNVDNEP EDEVEEENIG TTDDPVRLYL KDMGGVDLLT
     REHEVEIAKR IEEGHKTMIA SLCRSPIAMR CFIVWYEDLV NEKMLLRDLI DLEANMLHDE
     TPENDEENSS ETEGEEHEDN HLSMSRVETQ ILPNIIERMK KIAFICEELL IEAKKCYEKS
     FEPKVLQNSK KYNNLELLIN EVSEIHFNSK RTEEILGKMY GINRDLINKE TAFLKLAEKY
     GVTRQNFLDE YIGSVINAAW KEKMLKNKKV AWKELMTKES DYIDQMIAEL SVIESKTGLL
     VNDFKKLVNT IQKSERQTLQ AKKDMIEANL RLVISIAKKY ANRGLQFLDL IQEGNIGLMK
     AVDKFEYRRG YKFSTYATWW IRQAITRAIA DQARTIRIPV HMIETINKIL RTSRQMLNEL
     GYEPTATEIA NRLSMPLDKV RKVMKIAKEP ISLENPVGDD SDGGQLGDFI EDKNAVAPID
     AAIQSNLREV TTRVLATLTP REERVLRMRF GIGMNTDHTL EEVGQQFKVT RERIRQIESK
     ALRKLQHPIR SKKLNSFRSG GKRGDGNSSD LLEA