RPOE_LACAC
ID RPOE_LACAC Reviewed; 184 AA.
AC Q5FME7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Probable DNA-directed RNA polymerase subunit delta {ECO:0000255|HAMAP-Rule:MF_00357};
DE AltName: Full=RNAP delta factor {ECO:0000255|HAMAP-Rule:MF_00357};
GN Name=rpoE {ECO:0000255|HAMAP-Rule:MF_00357}; OrderedLocusNames=LBA0232;
OS Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=272621;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA Hamrick A., Cano R., Klaenhammer T.R.;
RT "Complete genome sequence of the probiotic lactic acid bacterium
RT Lactobacillus acidophilus NCFM.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC -!- FUNCTION: Participates in both the initiation and recycling phases of
CC transcription. In the presence of the delta subunit, RNAP displays an
CC increased specificity of transcription, a decreased affinity for
CC nucleic acids, and an increased efficiency of RNA synthesis because of
CC enhanced recycling. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC subunits. The core is associated with a delta subunit and one of
CC several sigma factors. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SIMILARITY: Belongs to the RpoE family. {ECO:0000255|HAMAP-
CC Rule:MF_00357}.
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DR EMBL; CP000033; AAV42127.1; -; Genomic_DNA.
DR RefSeq; WP_003548904.1; NC_006814.3.
DR RefSeq; YP_193158.1; NC_006814.3.
DR AlphaFoldDB; Q5FME7; -.
DR SMR; Q5FME7; -.
DR STRING; 272621.LBA0232; -.
DR PRIDE; Q5FME7; -.
DR EnsemblBacteria; AAV42127; AAV42127; LBA0232.
DR GeneID; 56941837; -.
DR KEGG; lac:LBA0232; -.
DR PATRIC; fig|272621.13.peg.222; -.
DR eggNOG; COG3343; Bacteria.
DR HOGENOM; CLU_116648_0_0_9; -.
DR OMA; TWGLRSW; -.
DR BioCyc; LACI272621:G1G49-226-MON; -.
DR Proteomes; UP000006381; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.1250; -; 1.
DR HAMAP; MF_00357; RNApol_bact_RpoE; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR038087; RNAP_delta_N_dom_sf.
DR InterPro; IPR029757; RpoE.
DR Pfam; PF05066; HARE-HTH; 1.
DR TIGRFAMs; TIGR04567; RNAP_delt_lowGC; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..184
FT /note="Probable DNA-directed RNA polymerase subunit delta"
FT /id="PRO_0000303125"
FT DOMAIN 14..81
FT /note="HTH HARE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01261"
FT REGION 88..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..165
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 21139 MW; F7ED3A91485A6165 CRC64;
MGLDKFKDKN RDELSMIEVA RAILEDNGKR MAFADIVNAV QKYLNKSDEE IRERLPQFYT
DMNTDGEFIS MGENVWALRS WFPYESVDEE VNHPEDEEED DSRKHHKKVN AFLASATGDD
DIIDYDNDDP EDDDLDAATD DSDDDYSDDD SDYDEDNDDA DDVLPDGIEG QLSQLNDEDD
DEDD
