ID   ATX10_BOVIN             Reviewed;         475 AA.
AC   Q2TBW0;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Ataxin-10;
DE   AltName: Full=Spinocerebellar ataxia type 10 protein homolog;
GN   Name=ATXN10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with OGT. Interacts with GNB2.
CC       Interacts with IQCB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family. {ECO:0000305}.
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DR   EMBL; BC109580; AAI09581.1; -; mRNA.
DR   RefSeq; NP_001070519.1; NM_001077051.2.
DR   AlphaFoldDB; Q2TBW0; -.
DR   SMR; Q2TBW0; -.
DR   STRING; 9913.ENSBTAP00000012308; -.
DR   PaxDb; Q2TBW0; -.
DR   PRIDE; Q2TBW0; -.
DR   GeneID; 767990; -.
DR   KEGG; bta:767990; -.
DR   CTD; 25814; -.
DR   eggNOG; KOG2676; Eukaryota.
DR   InParanoid; Q2TBW0; -.
DR   OrthoDB; 1416864at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Ataxin-10"
FT                   /id="PRO_0000351654"
FT   MOD_RES         10
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P28658"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
SQ   SEQUENCE   475 AA;  53102 MW;  F06E429E7DFB84F2 CRC64;
     MAAPRPPPGR LSGVMMPAPI QDLEALRALT ALFKEQRNRD TAPRTIFQRV LDILKKSSHA
     VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN SIRNLGTIGV AVDLILLFRE
     LRVEQDSLLT AFRCGLQFLG NIASRNEDSQ SVVWMHAFPE LFLSCLNHPD RKIVAYSSMI
     LFTSLNSERM KELEENLNIA IDVVEAHQKQ PESEWPFLII TDHFLKSPEL VKAMYAKMSN
     QERVTLLDLM IAKIVGDEPL TKDDAPVFLS HAELIASTFV DQCKIVLKLT SEQHTDDEEA
     LATIRLLDVL CEKTANTDLL GYLQVFPGLL ERVIDLLRLI HVAGNDSTNI FSACASIKAD
     GDVSSVAEGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL ILDSCGLDDS NPFLTQWVVY
     AIRNLTEDNS QNQDLIAKME EQGLADASLL KKMGFEVEKR GDKLILKSTS DTPQL