ID   ATX10_MACFA             Reviewed;         475 AA.
AC   Q4R4Y2;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Ataxin-10;
DE   AltName: Full=Spinocerebellar ataxia type 10 protein homolog;
GN   Name=ATXN10; ORFNames=QtrA-11108;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with OGT. Interacts with GNB2.
CC       Interacts with IQCB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family. {ECO:0000305}.
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DR   EMBL; AB169762; BAE01843.1; -; mRNA.
DR   RefSeq; NP_001270460.1; NM_001283531.1.
DR   AlphaFoldDB; Q4R4Y2; -.
DR   STRING; 9541.XP_005567065.1; -.
DR   GeneID; 101925440; -.
DR   CTD; 25814; -.
DR   VEuPathDB; HostDB:ENSMFAG00000030950; -.
DR   eggNOG; KOG2676; Eukaryota.
DR   OMA; DICAWES; -.
DR   OrthoDB; 1416864at2759; -.
DR   Proteomes; UP000233100; Chromosome 10.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Ataxin-10"
FT                   /id="PRO_0000351655"
FT   MOD_RES         10
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P28658"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
SQ   SEQUENCE   475 AA;  53429 MW;  3C6CFF13010CD8E8 CRC64;
     MAAPRPPPAR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSSHA
     VELACRDPSQ VENLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLILLFRE
     LRVEQEALLT AFRCGLQFLG NIASRNEDSQ SIVWVHAFPE LFLSCLNHPD KKIVAYSSMI
     LFTSLNHERM KELEENLNIA IDVIDAYQKH PESEWPVLII TDLFLKSPEL VQAMFPKLNN
     QERVTLLDLM IAKITSDEPL TTDDIPVFLR HAELIASTFV DQCKTVLKLA SEEPPDDEEA
     LATIRLLDVL CEMTANTELL GYLQVFPGLL ERVIDLLRVI HVTGKETTNI FSNCGCVRAE
     GDISNVAEGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL ILDNCNISDS NPFLTQWVIY
     AIRNLTEDNS QNQDLIAKME EQGLADASLL KKVGFEVEKK GEKLILKSTR DTPKP