RPOE_STRMU
ID RPOE_STRMU Reviewed; 194 AA.
AC Q8DWG2;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 30-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Probable DNA-directed RNA polymerase subunit delta {ECO:0000255|HAMAP-Rule:MF_00357};
DE AltName: Full=RNAP delta factor {ECO:0000255|HAMAP-Rule:MF_00357};
GN Name=rpoE {ECO:0000255|HAMAP-Rule:MF_00357}; OrderedLocusNames=SMU_96;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC -!- FUNCTION: Participates in both the initiation and recycling phases of
CC transcription. In the presence of the delta subunit, RNAP displays an
CC increased specificity of transcription, a decreased affinity for
CC nucleic acids, and an increased efficiency of RNA synthesis because of
CC enhanced recycling. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC subunits. The core is associated with a delta subunit and one of
CC several sigma factors. {ECO:0000255|HAMAP-Rule:MF_00357}.
CC -!- SIMILARITY: Belongs to the RpoE family. {ECO:0000255|HAMAP-
CC Rule:MF_00357}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN57879.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014133; AAN57879.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_720573.3; NC_004350.2.
DR RefSeq; WP_002263574.1; NC_004350.2.
DR AlphaFoldDB; Q8DWG2; -.
DR SMR; Q8DWG2; -.
DR STRING; 210007.SMU_96; -.
DR PRIDE; Q8DWG2; -.
DR EnsemblBacteria; AAN57879; AAN57879; SMU_96.
DR KEGG; smu:SMU_96; -.
DR PATRIC; fig|210007.7.peg.82; -.
DR eggNOG; COG3343; Bacteria.
DR HOGENOM; CLU_116648_1_0_9; -.
DR OMA; TWGLRSW; -.
DR PhylomeDB; Q8DWG2; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.1250; -; 1.
DR HAMAP; MF_00357; RNApol_bact_RpoE; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR038087; RNAP_delta_N_dom_sf.
DR InterPro; IPR029757; RpoE.
DR Pfam; PF05066; HARE-HTH; 1.
DR TIGRFAMs; TIGR04567; RNAP_delt_lowGC; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome;
KW Transcription; Transferase.
FT CHAIN 1..194
FT /note="Probable DNA-directed RNA polymerase subunit delta"
FT /id="PRO_0000204328"
FT DOMAIN 14..83
FT /note="HTH HARE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01261"
FT REGION 117..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..194
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 194 AA; 22478 MW; 3BEFA12A4808DA53 CRC64;
MELEVFAGQE KSELSMIEVA RAILEERGRD KEMYFSDLVN AIQVYLEKSD ADIREALPFF
YSDLNTDGSF IPLGENKWGL RSWYGIDEID EEIVTLEEDE DGAPKHKRKR VNAFMDGDED
AIDYSDDDPE DESFNTAEED TEYDEEDPDD EKSEVESYDS EINEIIPDED LDENVDLDEE
DDDYSDDEED EEGE
