ATX10_MOUSE
ID ATX10_MOUSE Reviewed; 475 AA.
AC P28658; Q543S3; Q99LP5; Q9D1I1;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Ataxin-10;
DE AltName: Full=Brain protein E46;
DE AltName: Full=Spinocerebellar ataxia type 10 protein homolog;
GN Name=Atxn10; Synonyms=Sca10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=12106288; DOI=10.1111/j.1460-9568.1990.tb00460.x;
RA Kato K.;
RT "A collection of cDNA clones with specific expression patterns in mouse
RT brain.";
RL Eur. J. Neurosci. 2:704-711(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Cerebellum, Embryo, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 244-253, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15201271; DOI=10.1074/jbc.m405865200;
RA Maerz P., Probst A., Lang S., Schwager M., Rose-John S., Otten U.,
RA Ozbek S.;
RT "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder
RT protein, is essential for survival of cerebellar neurons.";
RL J. Biol. Chem. 279:35542-35550(2004).
RN [6]
RP INTERACTION WITH OGT.
RX PubMed=16182253; DOI=10.1016/j.bbrc.2005.09.026;
RA Andrali S.S., Maerz P., Ozcan S.;
RT "Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta
RT cells.";
RL Biochem. Biophys. Res. Commun. 337:149-153(2005).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-10, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC role in the maintenance of a critical intracellular glycosylation level
CC and homeostasis. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer (By similarity). Interacts with GNB2 (By
CC similarity). Interacts with OGT. Interacts with IQCB1 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC P28658; Q8BP00: Iqcb1; NbExp=2; IntAct=EBI-4284019, EBI-4282243;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In high cell density areas; cerebellar cortex,
CC dentate gyrus, hippocampus, anterior olfactory nucleus, primary
CC olfactory cortex. {ECO:0000269|PubMed:15201271}.
CC -!- SIMILARITY: Belongs to the ataxin-10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA43722.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X61506; CAA43722.1; ALT_FRAME; mRNA.
DR EMBL; AK003530; BAB22840.1; -; mRNA.
DR EMBL; AK047170; BAC32981.1; -; mRNA.
DR EMBL; AK078459; BAC37285.1; -; mRNA.
DR EMBL; AK153271; BAE31858.1; -; mRNA.
DR EMBL; AK165941; BAE38473.1; -; mRNA.
DR EMBL; AK170507; BAE41845.1; -; mRNA.
DR EMBL; BC002285; AAH02285.1; -; mRNA.
DR EMBL; BC016410; AAH16410.1; -; mRNA.
DR EMBL; BC046802; AAH46802.1; -; mRNA.
DR CCDS; CCDS37170.1; -.
DR PIR; S16416; S16416.
DR RefSeq; NP_058539.2; NM_016843.3.
DR AlphaFoldDB; P28658; -.
DR SMR; P28658; -.
DR BioGRID; 207574; 14.
DR IntAct; P28658; 6.
DR MINT; P28658; -.
DR STRING; 10090.ENSMUSP00000132450; -.
DR iPTMnet; P28658; -.
DR PhosphoSitePlus; P28658; -.
DR SwissPalm; P28658; -.
DR EPD; P28658; -.
DR jPOST; P28658; -.
DR MaxQB; P28658; -.
DR PaxDb; P28658; -.
DR PeptideAtlas; P28658; -.
DR PRIDE; P28658; -.
DR ProteomicsDB; 273589; -.
DR Antibodypedia; 27938; 204 antibodies from 27 providers.
DR DNASU; 54138; -.
DR Ensembl; ENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541.
DR GeneID; 54138; -.
DR KEGG; mmu:54138; -.
DR UCSC; uc007xdd.1; mouse.
DR CTD; 25814; -.
DR MGI; MGI:1859293; Atxn10.
DR VEuPathDB; HostDB:ENSMUSG00000016541; -.
DR eggNOG; KOG2676; Eukaryota.
DR GeneTree; ENSGT00390000010377; -.
DR HOGENOM; CLU_046084_1_0_1; -.
DR InParanoid; P28658; -.
DR OMA; DICAWES; -.
DR OrthoDB; 1416864at2759; -.
DR PhylomeDB; P28658; -.
DR TreeFam; TF323870; -.
DR BioGRID-ORCS; 54138; 15 hits in 74 CRISPR screens.
DR ChiTaRS; Atxn10; mouse.
DR PRO; PR:P28658; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P28658; protein.
DR Bgee; ENSMUSG00000016541; Expressed in motor neuron and 254 other tissues.
DR Genevisible; P28658; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0060271; P:cilium assembly; IMP:MGI.
DR GO; GO:0007399; P:nervous system development; ISO:MGI.
DR GO; GO:0031175; P:neuron projection development; ISO:MGI.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019156; Ataxin-10_domain.
DR Pfam; PF09759; Atx10homo_assoc; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Methylation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..475
FT /note="Ataxin-10"
FT /id="PRO_0000064749"
FT MOD_RES 10
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBB4"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBB4"
FT CONFLICT 31
FT /note="A -> V (in Ref. 1; CAA43722)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 53707 MW; 273FDB6EDFE519C7 CRC64;
MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSTHA
VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLVLLFRE
LRVEQDSLLT AFRCGLQFLG NVASRNEESQ SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI
LFTSLNAERM KDLEENLNIA INVIEAHQKH PASEWPFLII SDHFLKSPEL VEAMYGKLSN
QERITLLDIV IAKLVGEEQL TKDDISIFVR HAELIANSFM DQCRNVLKLT SEPHTEDKEA
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HEVGKESTNI FSPSDSLKAE
GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL ILDSSNIDDN NPFMMQWVVY
AVRNLTEDNS QNQDVIAKME EQGLADASLL KKMGFEIEKS GDKLILKSNN DIPPP
