ID   ATX10_PONAB             Reviewed;         476 AA.
AC   Q5RE06;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Ataxin-10;
DE   AltName: Full=Spinocerebellar ataxia type 10 protein homolog;
GN   Name=ATXN10;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with OGT. Interacts with GNB2.
CC       Interacts with IQCB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family. {ECO:0000305}.
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DR   EMBL; CR857733; CAH90001.1; -; mRNA.
DR   RefSeq; NP_001124949.1; NM_001131477.1.
DR   AlphaFoldDB; Q5RE06; -.
DR   STRING; 9601.ENSPPYP00000013323; -.
DR   PRIDE; Q5RE06; -.
DR   GeneID; 100171821; -.
DR   KEGG; pon:100171821; -.
DR   CTD; 25814; -.
DR   eggNOG; KOG2676; Eukaryota.
DR   InParanoid; Q5RE06; -.
DR   OrthoDB; 1416864at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Ataxin-10"
FT                   /id="PRO_0000351656"
FT   MOD_RES         10
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P28658"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
FT   MOD_RES         431
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBB4"
SQ   SEQUENCE   476 AA;  53561 MW;  B8864782983F5EC5 CRC64;
     MAAPRLPPAR ALSGVMVPAP IQDLEALRAL TALFKEQRNR ETAPRTIFQR VLDILKKSSH
     AVELACRDPS QVENLASSLQ LITECFRCLR NACIECSVNQ NSIRNLDAIG VAVDLILLFR
     ELRVEQESLL TAFRCGLQFL GNIASRNEDS QSIVWVHAFP ELFLSCLNHP DKKIVAYSSM
     ILFTSLNHER MKELEENLNI AIDVIDAYQK HPESEWPFLI ITDLFLKSPE LVQAMFPKLN
     NQERVTLLDL MIAKITSDEP LTKDDIPVFL RHAELIASTF VDQCKTVLKL ASEEPPDDEE
     ALATIRLLDV LCEMTVNTEL LGYLQVFPGL LERVIDLLRV IHVAGKETTN IFSNCGCVRA
     EGDISNVAEG FKSHLIRLIG NLCYKNKDNQ DKVNELDGIP LILDNCNISD SNPFLTQWVI
     YAIRNLTEDN SQNQDLIAKM EEQGLADASL LKKVGFEVEK KGEKLILKST RDTPKP