ID   ATX10_XENTR             Reviewed;         485 AA.
AC   Q5FVB0;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Ataxin-10;
DE   AltName: Full=Spinocerebellar ataxia type 10 protein homolog;
GN   Name=atxn10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family. {ECO:0000305}.
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DR   EMBL; BC090108; AAH90108.1; -; mRNA.
DR   RefSeq; NP_001015825.1; NM_001015825.1.
DR   AlphaFoldDB; Q5FVB0; -.
DR   SMR; Q5FVB0; -.
DR   STRING; 8364.ENSXETP00000006675; -.
DR   DNASU; 548542; -.
DR   GeneID; 548542; -.
DR   KEGG; xtr:548542; -.
DR   CTD; 25814; -.
DR   Xenbase; XB-GENE-959678; atxn10.
DR   eggNOG; KOG2676; Eukaryota.
DR   InParanoid; Q5FVB0; -.
DR   OrthoDB; 1416864at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003072; Expressed in testis and 12 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..485
FT                   /note="Ataxin-10"
FT                   /id="PRO_0000351657"
SQ   SEQUENCE   485 AA;  53830 MW;  F1CB8F92E169F386 CRC64;
     MAAPVERLAG VCAELEQWLG EESGQRNDWA EGEGIVWRLS ELFREAQYRE LAEPRIFRLI
     LQILSRVSCE IKVATLPAGA FTDTHCQLPA ECFRCLRNAC VQCASNQDSV RNVGLIEESV
     RLIQIFGAPH VLQEPALVAF RCGLQFLGNT AAGNRDSQNA VWACAFPDLF LSCLVHDDEK
     VVTYSSMVLF TCINREKVST LQDPSKLDVA LSVVTAYSKY PDAEWMYLIV MDHFLLCPDL
     VKAVYLSQSS PERVTLLELI LGKISQKEPL SAEESEALQA IAAFLSDCFQ TQCKTILKLT
     SPSACDEEEP IVVTRLLDIL CEVTSKNEHL SCLQTCPGLL EAAVDILRLT HLAGKQSMNV
     FTAAHTMSMG QDLTHAAVGF KAHLIRLIGN LCYQNKENQE KVYQLDGIAL ILDNCSIDDN
     NPFLNQWAVF AIRNLTENND KNQELIASME RQGLADSSLL KSMGLQAEER DGKLLLKSVK
     KSPAL