RPOL_BPK11
ID RPOL_BPK11 Reviewed; 906 AA.
AC P18147;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=DNA-directed RNA polymerase;
DE EC=2.7.7.6;
GN Name=1;
OS Enterobacteria phage K11 (Bacteriophage K11).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Podoviridae.
OX NCBI_TaxID=10766;
OH NCBI_TaxID=570; Klebsiella.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2370850; DOI=10.1007/bf00261733;
RA Dietz A., Weisser H.J., Koessel H., Hausmann R.;
RT "The gene for Klebsiella bacteriophage K11 RNA polymerase: sequence and
RT comparison with the homologous genes of phages T7, T3, and SP6.";
RL Mol. Gen. Genet. 221:283-286(1990).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10031,
CC ECO:0000255|PROSITE-ProRule:PRU10032};
CC -!- SIMILARITY: Belongs to the phage and mitochondrial RNA polymerase
CC family. {ECO:0000305}.
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DR EMBL; X53238; CAA37330.1; -; Genomic_DNA.
DR PIR; S10530; RNBPK1.
DR SMR; P18147; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1320.10; -; 1.
DR Gene3D; 1.10.287.260; -; 1.
DR InterPro; IPR024075; DNA-dir_RNA_pol_helix_hairp_sf.
DR InterPro; IPR002092; DNA-dir_Rpol_phage-type.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR037159; RNA_POL_N_sf.
DR InterPro; IPR029262; RPOL_N.
DR PANTHER; PTHR10102; PTHR10102; 1.
DR Pfam; PF00940; RNA_pol; 1.
DR Pfam; PF14700; RPOL_N; 1.
DR SMART; SM01311; RPOL_N; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS00900; RNA_POL_PHAGE_1; 1.
DR PROSITE; PS00489; RNA_POL_PHAGE_2; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW Transferase; Viral transcription.
FT CHAIN 1..906
FT /note="DNA-directed RNA polymerase"
FT /id="PRO_0000087747"
FT ACT_SITE 560
FT /evidence="ECO:0000250"
FT ACT_SITE 654
FT /evidence="ECO:0000250"
FT ACT_SITE 835
FT /evidence="ECO:0000250"
SQ SEQUENCE 906 AA; 101128 MW; 9E6D7FA3933CF84F CRC64;
MNALNIGRND FSEIELAAIP YNILSEHYGD QAAREQLALE HEAYELGRQR FLKMLERQVK
AGEFADNAAA KPLVLTLHPQ LTKRIDDWKE EQANARGKKP RAYYPIKHGV ASELAVSMGA
EVLKEKRGVS SEAIALLTIK VVLGNAHRPL KGHNPAVSSQ LGKALEDEAR FGRIREQEAA
YFKKNVADQL DKRVGHVYKK AFMQVVEADM ISKGMLGGDN WASWKTDEQM HVGTKLLELL
IEGTGLVEMT KNKMADGSDD VTSMQMVQLA PAFVELLSKR AGALAGISPM HQPCVVPPKP
WVETVGGGYW SVGRRPLALV RTHSKKALRR YADVHMPEVY KAVNLAQNTP WKVNKKVLAV
VNEIVNWKHC PVGDVPAIER EELPPRPDDI DTNEVARKAW RKEAAAVYRK DKARQSRRCR
CEFMVAQANK FANHKAIWFP YNMDWRGRVY AVSMFNPQGN DMTKGSLTLA KGKPIGLDGF
YWLKIHGANC AGVDKVPFPE RIKFIEENEG NILASAADPL NNTWWTQQDS PFCFLAFCFE
YAGVKHHGLN YNCSLPLAFD GSCSGIQHFS AMLRDSIGGR AVNLLPSDTV QDIYKIVADK
VNEVLHQHAV NGSQTVVEQI ADKETGEFHE KVTLGESVLA AQWLQYGVTR KVTKRSVMTL
AYGSKESLVR QQVLEDTIQP AIDNGEGLMF THPNQAAGYM AKLIWDAVTV TVVAAVEAMN
WLKSAAKLLA AEVKDKKTKE VLRKRCAIHW VTPDGFPVWQ EYRKQNQARL KLVFLGQANV
KMTYNTGKDS EIDAHKQESG IAPNFVHSQD GSHLRMTVVH ANEVYGIDSF ALIHDSSGTI
PADAGNLFKA VRETMVKTYE DNDVIADFYD QFADQLHESQ LDKMPAVPAK GDLNLRDILE
SDFAFA
