AB45G_ORYSJ
ID AB45G_ORYSJ Reviewed; 1350 AA.
AC Q8GU82; Q0J3Z6; Q6ZBI0;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=ABC transporter G family member 45 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG45 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 1 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR1 {ECO:0000303|PubMed:16506311};
GN Name=ABCG45 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR1 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os08g0544400 {ECO:0000312|EMBL:BAF24319.1},
GN LOC_Os08g43120; ORFNames=P0623F08.24 {ECO:0000312|EMBL:BAD09728.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 876-1350.
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD09728.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF24319.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD59576.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ535054; CAD59576.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004632; BAD09728.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008214; BAF24319.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK107688; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015649925.1; XM_015794439.1.
DR AlphaFoldDB; Q8GU82; -.
DR SMR; Q8GU82; -.
DR STRING; 4530.OS08T0544400-01; -.
DR PaxDb; Q8GU82; -.
DR PRIDE; Q8GU82; -.
DR GeneID; 4346210; -.
DR KEGG; osa:4346210; -.
DR eggNOG; KOG0065; Eukaryota.
DR OrthoDB; 324553at2759; -.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000059680; Chromosome 8.
DR Genevisible; Q8GU82; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1350
FT /note="ABC transporter G family member 45"
FT /id="PRO_0000433455"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..617
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1181..1201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1208..1228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1238..1258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1269..1289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1322..1342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 85..357
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 434..647
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 749..1001
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1074..1288
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 118..125
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 794..801
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1350 AA; 152556 MW; C25426E26CF34D90 CRC64;
MAAAVELTGD GGTTAETRWL SPPLTHDDNR GFLQMLREKK ERLGVGAAKV EVRLEKLTVE
ADVRVGRRAV PTLLNCAINA AQELAACAHM CTTRKKPMKI INEATGTIRP SRMTLLLGAP
GSGKTTLLKA LAGKLDSSLK MKGKVTYNGE EVNSSTPQYL HAYVSQYDLH HAEMTVRETI
DFSSKMLGTN NEFEMLGEAI RRKKGVINRV DQELDSFIKA TTFGEGSNLT TNYIIKILGL
SECADTLVGD EMRRGISGGQ KKRATIGEML VGLARCFFMD DISTGLDSST TFEIMKFLQQ
MAHLMDLTMV ISLLQPPPET LELFDDIILL CEGQIVYHGP RENATDFFET MGFKCPSRKN
VADFLQEVTS KMDQKQYWIG NANKYQYHSI EKFAESFRTS YLPRLVENDH FESTNAGKSK
EVKTSTSRMI SSWNIFKACF SREVLLLKRN SPVHIFKTIQ ITVLALVIST LFLRTNMRHD
TVLDANKYMG ALFMAVVIVN FNGMTEIAMT IKRLPIFYKQ REILALPGWA LLSSVFLLSL
PISFVETGLW TGLTYYVIGY APSFVRFIQH FVVLFAMHQM SMSLYRFLAA IGRTQVMANM
LGTAALIAIY ILGGFVISKD NLQPWLRWGY WTSPFTYAQN AVALNEFLDD RWATEFHFAN
ANTVGETILK VRGLLTEWHW YWICVSILFG FSLVFNILSI FALQYMRSPH KHQVNINATK
VKVDYNSQIV GNGTASTDQV ILPFQPLSLV FDHINYFVDM PKEMTKYGVT DKKLQLLQDV
SGAFRPGVLT ALMGITGAGK TTLLDVLAGR KTGGYIEGTV KIAGYPKKQE TFSRISGYCE
QSDIHSPNLT VYESLQFSAW LRLPSNVKSH QRNMFIDEVM DLVELTGLKN AMVGLAGATG
LSAEQRKRLT IAVELVASPS IIFMDEPTTG LDARAAAIVM RTVRKTVDTG RTVVCTIHQP
SIEIFESFDE LLLMKRGGQL IYSGSLGPLS SNMIKYFEAI PGVPRIKEGQ NPAAWMLDIS
SRTAEYEIGV DYAEIYQRSS LYWENRQLID DLGKPEPNTE DLHFPPKYWQ DFRAQCMACL
WKQNCAYWKN SEHNVVRFIN TFAVSIMFGI VFWKIGSTIK DEQDVFNILG VVYGSALFLG
FMNCSILQPV VGMERVVLYR EKAAGMYSTM AYAIAQVAVE LPYMFVQVFI FSAIVYPMIG
FQMTATKFFW FALYMVLSFL YYTLYGMMTV ALTPNIEIAA GLSFLIFIFW NVFSGFIIGR
QMIPVWWRWV YWANPAAWTV YGLMFSQLGD RTELIQVPGQ PEQTVKEFLE GYLGLQDRYF
NLVTSLHVAI IALFTFLFFL SIKHLKFQRR
