ID   RPOY_STRPN              Reviewed;          77 AA.
AC   Q97T34;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA-directed RNA polymerase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01553};
DE            Short=RNAP epsilon subunit {ECO:0000255|HAMAP-Rule:MF_01553};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01553};
DE   AltName: Full=RNA polymerase epsilon subunit {ECO:0000255|HAMAP-Rule:MF_01553};
DE   AltName: Full=Transcriptase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01553};
GN   Name=rpoY {ECO:0000255|HAMAP-Rule:MF_01553}; OrderedLocusNames=SP_0122;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: A non-essential component of RNA polymerase (RNAP).
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01553};
CC   -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC       subunit. The core is associated with a delta subunit, and at least one
CC       of epsilon or omega. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
CC   -!- INTERACTION:
CC       Q97T34; A0A0H2UN16: SP_0099; NbExp=4; IntAct=EBI-6475457, EBI-6475454;
CC   -!- SIMILARITY: Belongs to the RNA polymerase subunit epsilon family.
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
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DR   EMBL; AE005672; AAK74308.1; -; Genomic_DNA.
DR   PIR; C95014; C95014.
DR   RefSeq; WP_000639589.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97T34; -.
DR   SMR; Q97T34; -.
DR   IntAct; Q97T34; 1.
DR   STRING; 170187.SP_0122; -.
DR   EnsemblBacteria; AAK74308; AAK74308; SP_0122.
DR   GeneID; 60232500; -.
DR   KEGG; spn:SP_0122; -.
DR   eggNOG; COG5503; Bacteria.
DR   OMA; TIYVEGE; -.
DR   PhylomeDB; Q97T34; -.
DR   BioCyc; SPNE170187:G1FZB-128-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01553; RNApol_bact_RpoY; 1.
DR   InterPro; IPR009907; RpoY.
DR   Pfam; PF07288; RpoY; 1.
PE   1: Evidence at protein level;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..77
FT                   /note="DNA-directed RNA polymerase subunit epsilon"
FT                   /id="PRO_0000163147"
SQ   SEQUENCE   77 AA;  9288 MW;  7274ABF5D212C3C3 CRC64;
     MIYKVFYQET KERSPRRETT RTLYLDIDAS SELEGRITAR QLVEENRPEY NIEYIELLSD
     KLLDYEKETG AFEITEF