ID   RPOY_STRPQ              Reviewed;          76 AA.
AC   P0DH19; Q79YG9; Q7CER9;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=DNA-directed RNA polymerase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01553};
DE            Short=RNAP epsilon subunit {ECO:0000255|HAMAP-Rule:MF_01553};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01553};
DE   AltName: Full=RNA polymerase epsilon subunit {ECO:0000255|HAMAP-Rule:MF_01553};
DE   AltName: Full=Transcriptase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01553};
GN   Name=rpoY {ECO:0000255|HAMAP-Rule:MF_01553}; OrderedLocusNames=SPs0248;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- FUNCTION: A non-essential component of RNA polymerase (RNAP).
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01553};
CC   -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC       subunit. The core is associated with a delta subunit, and at least one
CC       of epsilon or omega. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase subunit epsilon family.
CC       {ECO:0000255|HAMAP-Rule:MF_01553}.
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DR   EMBL; BA000034; BAC63343.1; -; Genomic_DNA.
DR   RefSeq; WP_002982907.1; NC_004606.1.
DR   AlphaFoldDB; P0DH19; -.
DR   SMR; P0DH19; -.
DR   GeneID; 57853277; -.
DR   KEGG; sps:SPs0248; -.
DR   HOGENOM; CLU_187518_0_0_9; -.
DR   OMA; TIYVEGE; -.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01553; RNApol_bact_RpoY; 1.
DR   InterPro; IPR009907; RpoY.
DR   Pfam; PF07288; RpoY; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..76
FT                   /note="DNA-directed RNA polymerase subunit epsilon"
FT                   /id="PRO_0000411649"
SQ   SEQUENCE   76 AA;  9146 MW;  F76F906995525E0C CRC64;
     MIYKVFYQET KDQSPRREST KALYLNIDAT DELDGRIKAR RLVEDNTYYN VEFIELLSDK
     HLDYEKETGV FELTEF