ATX3_ORYSJ
ID ATX3_ORYSJ Reviewed; 336 AA.
AC Q8LQ36; Q0JHP3;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Putative ataxin-3 homolog;
DE EC=3.4.19.12;
GN OrderedLocusNames=Os01g0851400, LOC_Os01g63250; ORFNames=P0529H11.31;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Interacts with key regulators of transcription and represses
CC transcription. Acts as a histone-binding protein that regulates
CC transcription. Acts as a deubiquitinating enzyme (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AP004072; BAB92851.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF06735.2; -; Genomic_DNA.
DR EMBL; AP014957; BAS75251.1; -; Genomic_DNA.
DR RefSeq; XP_015614266.1; XM_015758780.1.
DR AlphaFoldDB; Q8LQ36; -.
DR SMR; Q8LQ36; -.
DR STRING; 4530.OS01T0851400-01; -.
DR MEROPS; C86.A01; -.
DR PaxDb; Q8LQ36; -.
DR PRIDE; Q8LQ36; -.
DR EnsemblPlants; Os01t0851400-01; Os01t0851400-01; Os01g0851400.
DR GeneID; 4324808; -.
DR Gramene; Os01t0851400-01; Os01t0851400-01; Os01g0851400.
DR KEGG; osa:4324808; -.
DR eggNOG; KOG2935; Eukaryota.
DR HOGENOM; CLU_031228_0_1_1; -.
DR InParanoid; Q8LQ36; -.
DR OMA; SGEWYNF; -.
DR OrthoDB; 1482722at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q8LQ36; OS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR InterPro; IPR033865; Ataxin-3.
DR InterPro; IPR006155; Josephin.
DR PANTHER; PTHR14159; PTHR14159; 1.
DR Pfam; PF02099; Josephin; 1.
DR SMART; SM01246; Josephin; 1.
DR PROSITE; PS50957; JOSEPHIN; 1.
PE 3: Inferred from homology;
KW Hydrolase; Nucleus; Protease; Reference proteome; Thiol protease;
KW Transcription; Transcription regulation; Ubl conjugation pathway.
FT CHAIN 1..336
FT /note="Putative ataxin-3 homolog"
FT /id="PRO_0000053837"
FT DOMAIN 10..193
FT /note="Josephin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT DOMAIN 244..263
FT /note="UIM"
FT /evidence="ECO:0000305"
FT REGION 281..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 23
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT ACT_SITE 132
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
FT ACT_SITE 147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00331"
SQ SEQUENCE 336 AA; 36205 MW; 84020FBEA78E8715 CRC64;
MEEAAAASNG GLLYHEVQEG KLCAVHCVNT TLQGPFFSEF DLSALAVDLD QRERQVMSEG
AAGAATTAAG DFLAEGEGSH NVSLGGDFSI QVLQKALEVW DLQVIPLDSP DVGSCLFDPE
LETAFICHLQ DHWFCIRKVN GEWYNFNSLY PAPEHLSKFY LSAFIDTLKG SGWSIFAVRG
NFPKECPMAT EGSNGFGQWL TPDDARRITS SCNQVQTPTQ QAGVSLVADQ SEEMSEMDMI
AAQQEEADLN AAIAASLMDT GGPFANYAAH EESRSQDAFA IESTSGEMSK DGNLEEQGAN
KSETSEPNSD NIESASGSNP KQNTTSLEGK ESIKED
