AB48G_ORYSJ
ID AB48G_ORYSJ Reviewed; 1470 AA.
AC Q8GU84; Q0IRX8; Q2R1Y0;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=ABC transporter G family member 48 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG48 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 3 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR3 {ECO:0000303|PubMed:16506311};
GN Name=ABCG48 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR3 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os11g0587600 {ECO:0000312|EMBL:BAF28537.2},
GN LOC_Os11g37700; ORFNames=P0704G09;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABA94465.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF28537.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ535052; CAD59574.1; -; Genomic_DNA.
DR EMBL; DP000010; ABA94465.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008217; BAF28537.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q8GU84; -.
DR SMR; Q8GU84; -.
DR STRING; 4530.OS11T0587600-01; -.
DR PaxDb; Q8GU84; -.
DR PRIDE; Q8GU84; -.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_3_1; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR Genevisible; Q8GU84; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1470
FT /note="ABC transporter G family member 48"
FT /id="PRO_0000433458"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 772..792
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1215..1234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1249..1271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1301..1321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1331..1351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1359..1379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1389..1409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1439..1459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 172..445
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 523..736
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
FT DOMAIN 869..1121
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1194..1408
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 205..212
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 914..921
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1470 AA; 164978 MW; 4541080D3162EE95 CRC64;
MAAAPSASGR RSMSWGSSIS QSFRQAEADD PFGRAASQQG HDDDEENLRW AALEKLPTYD
RMRRGVIRTA LLHHDGGGDG GGAAAAAKDG RMELVDIQKL AAGNLGRALL DRVFQDDSER
FLRRLRDRID MVGIELPTIE VRYEQLSIQA EVFVGSRALP TLTNAATNVL QGLIGRFGSS
NKRTINILQD VSGIIKPSRM TLLLGPPSSG KSTLMRALTG KLDKNLKVSG DITYCGHTFS
EFYPERTSAY VSQYDLHNAE MTVRETLDFS GRCLGIGARY DMLAELARRE RNAGIKPDPE
IDAFMKATAV QGHKTNITTD VTLKALGLDI CADIIIGDEM IRGISGGQKK RVTTGEMLTG
PARALFMDEI STGLDSSSTF EIVKYIGHLV HVMNETVMIS LLQPPPETYN LFDDIILLSE
GYIVYHGPRE NILEFFENAG FRCPERKGIA DFLQEVTSKK DQQQYWYHDQ ERYRYVSVPE
FAQRFKSFHV GQKMQKEMQI PYDKSSTHPA ALTTTKYGLS SWESLRAVMS REWLLMKRNS
FIYIFKVTQL IILAFMSMTV FLRTKMPSGT ISDGTKFLGA LTFSLITILF NGFAELQLTI
KKLPVFYKHR DFLFFPAWTF GVANILLKVP VSLVEAAVWV VLTYYVMGFA PSAGRFFRQF
IAFFVTHQMA MAMFRFLGAI LKTMVVANTF GMFVLLIVFI FGGFLISRND IKPWWIWGYW
ASPMMYSQQA ISINEFLASR WAIPNTDATI DEPTVGKAIL KSKGLITSDG GFWISIGALI
GFLVVFNILY ILALTYLSPG GSSNTIVSDE DSEDKTDMKT RNEQQMSQIV HNNGASNTSA
TSSIPMSGSR STNQQSRSQI VLPFQPLSLC FNHVNYYVDM PTEMKEQGFT ESRLQLLSDI
SGVFRPGVLT ALVGVSGAGK TTLMDVLAGR KTSGVIEGDI TLSGYPKKQE TFARISGYCE
QTDIHSPNVT VYESILYSAW LRLSSDVDTN TRKMFVDEVM SLVELDVLRN ALVGLPGVSG
LSTEQRKRLT IAVELVANPS VIFMDEPTSG LDARAAAIVM RTVRNTVNTG RTVVCTIHQP
SIDIFESFDE LLLLKRGGQV IYAGELGRHS HKLVEYFEAV PGVPKITEGY NPATWMLEVT
SPIAEARLNV NFAEIYANSE LYRKNQELIK ELSTPPPGYQ DLSFPTKYSQ NFYSQCIANF
WKQYRSYWKN PPYNAMRYLM TLLNGLVFGT VFWQKGTKIS SQQDLFNLLG ATYAATFFLG
AANCITVQPV VSIERTVFYR ERAAGMYSSL SYAFAQACVE VIYNILQGIL YTIIIYAMIG
YDWKADKFFY FMFFIVASFN YFTLFGMMLV ACTPSAMLAN ILISFVLPLW NLFAGFLVVR
PLIPIWWRWY YWANPVSWTI YGVVASQFGK NGDVLSVPGG SPTVVKQFLE DNLGMRHSFL
GYVVLTHFGY IIVFFFIFGY AIKYFNFQKR
