AB49G_ORYSJ
ID AB49G_ORYSJ Reviewed; 1480 AA.
AC Q2QV81; B9GCJ4; C7J9R6; Q0IP72;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=ABC transporter G family member 49 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG49 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 22 {ECO:0000303|PubMed:16506311};
DE Short=OsPDR22 {ECO:0000303|PubMed:16506311};
GN Name=ABCG49 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR22 {ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os12g0239900/Os12g0239950 {ECO:0000312|EMBL:BAF29493.1,
GN ECO:0000312|EMBL:BAH95593.1}, LOC_Os12g13720;
GN ORFNames=OsJ_35688 {ECO:0000312|EMBL:EEE53001.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1409-1480.
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABA96866.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF29493.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os12g0239900 and Os12g0239950.; Evidence={ECO:0000305};
CC Sequence=BAH95593.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os12g0239900 and Os12g0239950.; Evidence={ECO:0000305};
CC Sequence=EEE53001.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DP000011; ABA96866.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008218; BAF29493.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008218; BAH95593.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000149; EEE53001.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK107869; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015620170.1; XM_015764684.1.
DR AlphaFoldDB; Q2QV81; -.
DR SMR; Q2QV81; -.
DR STRING; 39947.Q2QV81; -.
DR PRIDE; Q2QV81; -.
DR GeneID; 9268322; -.
DR KEGG; osa:9268322; -.
DR OrthoDB; 37708at2759; -.
DR Proteomes; UP000000763; Chromosome 12.
DR Proteomes; UP000007752; Chromosome 12.
DR Proteomes; UP000059680; Chromosome 12.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1480
FT /note="ABC transporter G family member 49"
FT /id="PRO_0000433459"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..676
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 699..719
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 725..745
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 811..831
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1226..1246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1254..1274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1311..1331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1340..1360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1368..1388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1396..1416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1449..1469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 212..485
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 563..775
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 877..1129
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1202..1418
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 245..252
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 922..929
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1480 AA; 165472 MW; 6097804A0FB69E80 CRC64;
MHTTTQATPQ KSMVMTTTNG GGVDPPQWPE EEEDEDAAAG SSCRVTAANG HHHHHQQLVV
SGELGGGGGG GGGGREKEDD ELKRKWAAIE RLPTADRLRL SLLSSTRGGG SSGDVSEGGG
GGAASSELEV VDVRWLGAAE RRAVVQRLVA DVKHDHVRML RKQRERMERV GVRPATVEVR
WRDVCVEAEC QVVSGKPLPT LWNAALSRFS LLAAKLGFSH HQSKVQILEN VSGIIKPSRI
TLLLGPPGCG KTTLLKALAG RLNKSLKETG EIEYNGVKLD EFVPAKTSAY VSQYDLHVAD
MTVRETLDFS ARFQGVGSRA EIMKAVIKRE KEAGITPDPD IDAYMKAISM EGLQRSMQTD
YIMKIMGLDK CADVKVGNAM RRGISGGEMK RLTTGEMIVG PCKVLLMDEI STGLDSSTTF
QIVSCLQQLA HISEYTILVS LLQPAPETYD LFDDIIIMGE GKVVYHGPKN LIMTFFESCG
FKCPERKGPA DFLQEVLSKK DQQQYWSRSE QWYNFITVDQ FCDKFKASQV GQSLAEDLSK
LYEKSKANKN ALSCSIYSLS KWHLLKACFD RELLLMKRNA FLHITKAVQL GLLAIITGTV
FFRTHKNFDI VSANYYMGSL FYALILLMVN GIPELVMSIS RLPVFYKHRD HYLYPGWAYA
IPAFILKIPA SLVAALSWTS ISYYLIGYTP EAPRYFRQLL VLFLVHTGAL SLYRCVGSYC
QTIAVGPIAA TMSLLVILLF GGFLIPRPSM PNWLKWGFWL SPLSYAEIGL TGNEFLAPRW
LKITISGVTI GRRILIDRGL DFSVYFYWIS VAALIGFILL YNIGFAIGLT IKQSPGASQA
IISNDKIRIC HGRDQEKSKD IKIGTRRMAL PFTPLTISFQ DVNYYVDTPP EMRKKGYMGR
KLQLLRNITG AFQPGILSAL MGVTGAGKTT LLDVLAGRKT GGVIEGDIRI GGYPKVQQTF
SRISGYCEQN DVHSPQITVG ESVAYSAWLR LPAEIDTKTR KEFVDEVLEI IELDEIRDAL
VGTPGVNGLS REQRKRLTIA VELVSNPSIV FMDEPTSGLD ARAAAIAMRA VKNVAETGRT
VVCTIHQPSI EIFEAFDELM LIKRGGELIY AGPLGQHSCK VIQYFQSIPG VPKIKDNYNP
STWMLEVTST SMEAQLGVDF AQIYTGSSIR KDKDELIKGF SMPPPGTSDL HFPTRFPQKF
LEQFKACLWK QFLSHWRTPS YNLVRIVFMA FSSIIFGVLY WQQGNIRHIN DQQGLFTILG
CMYGITIFTG INNSQSAMPF VAVERSVMYR ERFAGMYSPW AYSFAQVAME IPYVLMLALL
FMLIAYPTIG YAWTAAKFCW FFYTMFCTLL YFVYFGMLIV SITPNLQVAS IYASSFYMTQ
HLLSGFVMPP SQIPKWWIWL YYISPMSWTL NLLFTTQFGF EDNSNILVFG ETKPIAAFVR
DYFGFHRELL PLSAIILAAY PVLFAILYGY SISRFNFQKR
