ID   ATXR4_ARATH             Reviewed;         325 AA.
AC   Q9FG08;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Histone-lysine N-methyltransferase ATXR4;
DE            EC=2.1.1.-;
DE   AltName: Full=Protein SET DOMAIN GROUP 38;
DE   AltName: Full=Trithorax-related protein 4;
DE            Short=TRX-related protein 4;
DE   Flags: Precursor;
GN   Name=ATXR4; Synonyms=SDG38, SET38; OrderedLocusNames=At5g06620;
GN   ORFNames=F15M7.15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA   Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA   Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT   "The Arabidopsis thaliana genome contains at least 29 active genes encoding
RT   SET domain proteins that can be assigned to four evolutionarily conserved
RT   classes.";
RL   Nucleic Acids Res. 29:4319-4333(2001).
CC   -!- FUNCTION: Histone methyltransferase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-
CC         methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. TRX/MLL
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB11411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP002543; BAB11411.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED91043.1; -; Genomic_DNA.
DR   RefSeq; NP_196280.2; NM_120745.3.
DR   AlphaFoldDB; Q9FG08; -.
DR   SMR; Q9FG08; -.
DR   BioGRID; 15829; 1.
DR   STRING; 3702.AT5G06620.1; -.
DR   PaxDb; Q9FG08; -.
DR   PRIDE; Q9FG08; -.
DR   ProteomicsDB; 241151; -.
DR   EnsemblPlants; AT5G06620.1; AT5G06620.1; AT5G06620.
DR   GeneID; 830550; -.
DR   Gramene; AT5G06620.1; AT5G06620.1; AT5G06620.
DR   KEGG; ath:AT5G06620; -.
DR   Araport; AT5G06620; -.
DR   TAIR; locus:2144138; AT5G06620.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_058310_0_0_1; -.
DR   InParanoid; Q9FG08; -.
DR   OMA; ICNHCLK; -.
DR   OrthoDB; 1001347at2759; -.
DR   PhylomeDB; Q9FG08; -.
DR   PRO; PR:Q9FG08; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FG08; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Signal; Transferase.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..325
FT                   /note="Histone-lysine N-methyltransferase ATXR4"
FT                   /id="PRO_0000233361"
FT   DOMAIN          42..295
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   325 AA;  36134 MW;  0695D0EE9599B0A2 CRC64;
     MSRLALNRYS RCFSRLKTLT TPLFFSSSAA SNRDGDYQIG PPPIRVGLTE SAGRAVFATR
     KIGAGDLIHT AKPVVACPSL LKLDSVCYLC LKKLMGSAKF EDRGVSYCSQ ECQENSKGFL
     DVETRADWSS FDDYCRTHNF KYPLMVKRLC CMIISGARPA DCLDILQPAV LSSEMISKIE
     DGYGLLWNAF RKANFKDDDV AFLTKQWYTA ILARIRINAF RIDLVGGSCG EDLLSLAAAS
     VEGEGAVGHA VYMLPSFYNH DCDPNAHIIW LHNADARLNT LRDVEEGEEL RICYIDASMG
     YEARQTILSQ GFGFLCNCLR CQSTD