AB4A_ARATH
ID AB4A_ARATH Reviewed; 937 AA.
AC Q9STT8; F4JCP3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=ABC transporter A family member 4;
DE Short=ABC transporter ABCA.4;
DE Short=AtABCA4;
DE AltName: Full=Putative ABC2 homolog 3;
GN Name=ABCA4; Synonyms=ATH3; OrderedLocusNames=At3g47750; ORFNames=T23J7.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41858.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41858.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78325.2; -; Genomic_DNA.
DR PIR; T07714; T07714.
DR RefSeq; NP_001319703.1; NM_001339331.1.
DR AlphaFoldDB; Q9STT8; -.
DR SMR; Q9STT8; -.
DR STRING; 3702.AT3G47750.1; -.
DR iPTMnet; Q9STT8; -.
DR PaxDb; Q9STT8; -.
DR PRIDE; Q9STT8; -.
DR ProteomicsDB; 244565; -.
DR EnsemblPlants; AT3G47750.1; AT3G47750.1; AT3G47750.
DR GeneID; 823929; -.
DR Gramene; AT3G47750.1; AT3G47750.1; AT3G47750.
DR KEGG; ath:AT3G47750; -.
DR Araport; AT3G47750; -.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q9STT8; -.
DR OMA; DFTNSAM; -.
DR OrthoDB; 130188at2759; -.
DR PhylomeDB; Q9STT8; -.
DR PRO; PR:Q9STT8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STT8; baseline and differential.
DR Genevisible; Q9STT8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..937
FT /note="ABC transporter A family member 4"
FT /id="PRO_0000240325"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 618..852
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 653..660
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 937 AA; 105483 MW; C5FE79C1FD8ACCC6 CRC64;
MANHVPASFL TRANALFRKN LTYQKRNIWS NVRLIVIPFY LCVLLVGIQV LFDTQVNNSA
DNRCGCRCIH KNGDGKCERK SCGLQYSSLT QASFCAFPNP PPLLPLLQIP RPETRLVDPA
RSSCRRTGSC PVTILVTGNN HTLGETLSRN LLSTSFAVNS SDHFLRNLAY NVLGTISEAD
YTNYLDPGIH SDLPIFQIRP YCTPTTNLSF SFRQPPITFH KEVRCVQGLN LWRNNSVEVN
DEIFKGYRQG NHEEIINEVA AAYDLLDTDR NKFNVTIWYN SSYKGNFKVQ DRRVKYVRVP
RSVNMVSNAY LRFLRGPGTK MLFDFVKEMP KQESMLRVDI ASVIGPIFLT WVIVLLFPVI
LNSLVYEKQQ HLRIIMKMHG LGDGPYWMIT YAYFLAISTL YIICLMIFGS AIGLKFFRFN
DYSIQFIFYF LCINLQISIA FLVSSAFSKV ETASVAAYLY VFGSGLLGGF LFQFMLEGLS
FPRGWIFVME LYPGFSLYRG LYEFSQYALK RQLNGSDGMK WKYFSDSAMD EVFYIIIIEW
FLALIAAYYM DRVSSSAKDP FLFLKNLIKK SPSPQRHSLQ RLGSSVSVEM EKLDVVEERA
KVEQLMLESS TSHAIVCDKL KKVYPGRDGN PPKMAVGGLS IAVPPGECFG MLGPNGAGKT
SFINMMTGLV KPTSGTALVE SLDICQDMDK VYTSMGVCPQ HDLLWETLTG REHLLFYGRL
KNLKGSDLNQ AIEESLKSVN LSREGVADKP AGKYSGGMKR RLSVAISLIG SPKVVYMDEP
STGLDPASRR SLWTAIKGAK KHTAIILTTH SMEEAEFLCD RLGIFVDGRL QCVGNPKELK
ARYGGSYVLT MTTSSEHEKD VEMLIQDVSP NAKKIYHIAG TQKFEIPKDE VRIAELFQAV
EKAKGNFRVF AWGLADTTLE DVFIKVARTA QASNVFS
