ID   AUGN_XENLA              Reviewed;         136 AA.
AC   Q7ZXZ6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Augurin {ECO:0000305};
DE   Flags: Precursor;
GN   Name=ecrg4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable hormone that may attenuate cell proliferation and
CC       induce senescence in the central nervous system.
CC       {ECO:0000250|UniProtKB:D4A540}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H1Z8}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q9H1Z8}.
CC   -!- SIMILARITY: Belongs to the augurin family. {ECO:0000305}.
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DR   EMBL; BC044044; AAH44044.1; -; mRNA.
DR   RefSeq; NP_001079181.1; NM_001085712.1.
DR   AlphaFoldDB; Q7ZXZ6; -.
DR   SMR; Q7ZXZ6; -.
DR   DNASU; 373779; -.
DR   GeneID; 373779; -.
DR   KEGG; xla:373779; -.
DR   CTD; 373779; -.
DR   Xenbase; XB-GENE-997590; ecrg4.L.
DR   OrthoDB; 1431738at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 373779; Expressed in internal ear and 6 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028173; Augurin.
DR   PANTHER; PTHR31613; PTHR31613; 1.
DR   Pfam; PF15187; Augurin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cleavage on pair of basic residues; Cytoplasm; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT   PROPEP          20..56
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT                   /id="PRO_0000446069"
FT   PEPTIDE         59..120
FT                   /note="Augurin"
FT                   /id="PRO_0000359773"
FT   PROPEP          121..136
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000363244"
SQ   SEQUENCE   136 AA;  16073 MW;  1D04069900BDA811 CRC64;
     MVVLLFLLVI LLCPDSTNGN KLRKMLQKRE AVEPSKPIVS VKESKANEFL NSLKRPKRQL
     WDRTRPEVQQ WYQQFLYMGF DEAKYEDDMS YWKNQGRGGS EYYGGFHQHH YDEDAAIGPR
     NPYTYRHGAG VNYDDY