ID   RPP29_PONAB             Reviewed;         220 AA.
AC   Q5R7B0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Ribonuclease P protein subunit p29;
GN   Name=POP4; Synonyms=RPP29;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC       generates mature tRNA molecules by cleaving their 5'-ends.
CC       {ECO:0000250|UniProtKB:O95707}.
CC   -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC       RNase P consists of a catalytic RNA moiety and 10 different protein
CC       chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC       RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC       'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC       'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC       subcomplex. All subunits of the RNase P complex interact with the
CC       catalytic RNA. Several subunits of RNase P are also part of the RNase
CC       MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC       protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC       also POP4 and POP5. {ECO:0000250|UniProtKB:O95707}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:O95707}.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 1 family. {ECO:0000305}.
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DR   EMBL; CR860208; CAH92350.1; -; mRNA.
DR   RefSeq; NP_001126383.1; NM_001132911.1.
DR   AlphaFoldDB; Q5R7B0; -.
DR   SMR; Q5R7B0; -.
DR   STRING; 9601.ENSPPYP00000010980; -.
DR   Ensembl; ENSPPYT00000011409; ENSPPYP00000010980; ENSPPYG00000009805.
DR   GeneID; 100173364; -.
DR   KEGG; pon:100173364; -.
DR   CTD; 10775; -.
DR   eggNOG; KOG4046; Eukaryota.
DR   GeneTree; ENSGT00390000010067; -.
DR   HOGENOM; CLU_078577_2_1_1; -.
DR   InParanoid; Q5R7B0; -.
DR   OMA; IPKSECV; -.
DR   OrthoDB; 1362700at2759; -.
DR   TreeFam; TF313883; -.
DR   Proteomes; UP000001595; Chromosome 19.
DR   GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000172; C:ribonuclease MRP complex; IEA:InterPro.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR   Gene3D; 2.30.30.210; -; 1.
DR   InterPro; IPR016848; RNase_P/MRP_Rpp29-subunit.
DR   InterPro; IPR036980; RNase_P/MRP_Rpp29_sf.
DR   InterPro; IPR023534; Rof/RNase_P-like.
DR   InterPro; IPR002730; Rpp29/RNP1.
DR   PANTHER; PTHR13348; PTHR13348; 1.
DR   Pfam; PF01868; RNase_P-MRP_p29; 1.
DR   PIRSF; PIRSF027081; RNase_P/MRP_p29_subunit; 1.
DR   SMART; SM00538; POP4; 1.
DR   SUPFAM; SSF101744; SSF101744; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; tRNA processing.
FT   CHAIN           1..220
FT                   /note="Ribonuclease P protein subunit p29"
FT                   /id="PRO_0000128420"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95707"
SQ   SEQUENCE   220 AA;  25464 MW;  CFD1861563DD648F CRC64;
     MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ LQRKAVVLEY
     FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL PLHELWKQYI RDLCNGLKPD
     TQPQMIQAKL LKADLHGAII SVTKSKCPSY VGITGILLQE TKHIFKIITK EDRLKVIPKL
     NCVFTVEIDG FISYIYGSKF QLRSSERSAK KFKAKGTIDL