RPP2D_ARATH
ID RPP2D_ARATH Reviewed; 1189 AA.
AC O49471; A0A1P8B4W0;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2018, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Probable disease resistance protein At4g19530 {ECO:0000305|PubMed:15165183};
DE EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};
GN OrderedLocusNames=At4g19530 {ECO:0000312|Araport:AT4G19530};
GN ORFNames=F24J7.90 {ECO:0000312|EMBL:CAA16930.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=15165183; DOI=10.1111/j.1365-313x.2004.02099.x;
RA Sinapidou E., Williams K., Nott L., Bahkt S., Toer M., Crute I.,
RA Bittner-Eddy P., Beynon J.;
RT "Two TIR:NB:LRR genes are required to specify resistance to Peronospora
RT parasitica isolate Cala2 in Arabidopsis.";
RL Plant J. 38:898-909(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17272265; DOI=10.1074/mcp.m600408-mcp200;
RA Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.;
RT "Multidimensional protein identification technology (MudPIT) analysis of
RT ubiquitinated proteins in plants.";
RL Mol. Cell. Proteomics 6:601-610(2007).
CC -!- FUNCTION: Probable disease resistance protein.
CC {ECO:0000303|PubMed:15165183}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O49471-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O49471-2; Sequence=VSP_059610;
CC -!- DOMAIN: The TIR domain mediates NAD(+) hydrolase (NADase) activity.
CC Self-association of TIR domains is required for NADase activity.
CC {ECO:0000255|PROSITE-ProRule:PRU00204}.
CC -!- SIMILARITY: Belongs to the disease resistance TIR-NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AL021768; CAA16930.1; -; Genomic_DNA.
DR EMBL; AL161551; CAB78955.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84195.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66629.1; -; Genomic_DNA.
DR PIR; T06146; T06146.
DR RefSeq; NP_001328514.1; NM_001341356.1. [O49471-1]
DR RefSeq; NP_193688.1; NM_118073.2. [O49471-2]
DR AlphaFoldDB; O49471; -.
DR SMR; O49471; -.
DR STRING; 3702.AT4G19530.1; -.
DR PaxDb; O49471; -.
DR PRIDE; O49471; -.
DR ProteomicsDB; 228234; -. [O49471-1]
DR EnsemblPlants; AT4G19530.1; AT4G19530.1; AT4G19530. [O49471-2]
DR EnsemblPlants; AT4G19530.2; AT4G19530.2; AT4G19530. [O49471-1]
DR GeneID; 827695; -.
DR Gramene; AT4G19530.1; AT4G19530.1; AT4G19530. [O49471-2]
DR Gramene; AT4G19530.2; AT4G19530.2; AT4G19530. [O49471-1]
DR KEGG; ath:AT4G19530; -.
DR Araport; AT4G19530; -.
DR TAIR; locus:2122985; AT4G19530.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_3_1; -.
DR InParanoid; O49471; -.
DR OMA; ECEPKEN; -.
DR OrthoDB; 86802at2759; -.
DR PhylomeDB; O49471; -.
DR PRO; PR:O49471; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O49471; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0006952; P:defense response; IEP:TAIR.
DR GO; GO:0002758; P:innate immune response-activating signal transduction; IDA:TAIR.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017; PTHR11017; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Hydrolase; Leucine-rich repeat; NAD;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1189
FT /note="Probable disease resistance protein At4g19530"
FT /id="PRO_0000444559"
FT DOMAIN 13..176
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT DOMAIN 225..478
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 641..664
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 666..685
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 698..721
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 733..754
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 755..777
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 779..800
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 801..825
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 826..849
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 850..868
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REGION 1134..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT VAR_SEQ 938..959
FT /note="Missing (in isoform 2)"
FT /id="VSP_059610"
SQ SEQUENCE 1189 AA; 135143 MW; 761FC8822C015B76 CRC64;
MATSSSVVSS VPQQHQVFLN FRGDELRNNF VSHLDKALRG KQINVFIDEA VEKGENLDNL
FKEIEKSRIA LAIISQKYTE SKWCLNELVK MKELEGKLVT IPIFYNVEPA TVRYQKEAFG
AALTKTQEND SDGQMKKWKE ALTYVSLLVG FPFNSKSKEK ETTLIDKIVD AVLQKLSKIS
SEESTSGSVD QGRGEEVEEA KADKISGLNQ RLKELEEKVA ITGDKRDETR IVEVVGMPGI
GKSTLLKAFY ETWKTRFLSS ALLQNISELV KAMGLGRLTG MLLKELLPDE NIDEETYEPY
KEKLLKNTVF IVLDGISDET HIQKLLKDHR KWAKKGSKIV IARRAVTRDL LHEDSMVRYT
YFVPLLSHRD GLNHFCHYAF RHFAAHQNNK EAFMKESKEF VRYARGHPLI LKLLGEELRE
KSLSYWEEKL KSLPKSLSQN IRDRVLQVTY DELSQVQKDA FLDIACFRSH DLVYVKSLLD
SSGPAFSKAT VTIDALKDMF MIYISDSRVE MHDLLYTFAM ELGPEARDDD GRGRHRIWHH
HNQDNKGRLN RLLKRPGGST SVRSFFLDMY VMKTDVTLGT DYLKNMRNLR YLKFYSSHCP
QECTPKENIH IPGELELPLE EVRCLHWLNF PKDELPQDFI PKNLVDLKLP YSKIRQIWRE
EKDAPKLRWV DLNHSSKLEN LSGLSQALNL ERLNLEGCTA LKTLLLGPEN MASLVFLNLK
GCTGLESLPK INLRSLKTLI LSNCSNLEEF WVISETLYTL YLDGTAIKTL PQDMVKLTSL
VKLYMKDCEM LVKLPEEFDK LKVLQELVCS GCKRLSSLPD VMKNMQCLQI LLLDGTAITK
IPHISSLERL CLSRNEKISC LSNDIRLLSQ LKWLDLKYCT KLVSIPELPT NLQCLDANGC
ESLTTVANPL ATHLPTEQIH STFIFTNCDK LDRTAKEVIT TYAQRKCQML SDALKRWNEG
FVPEALFSTC FPGCEVPSWF CHEAVGSVLK LNLLPHWNEN RFVGIALCAV VGSLPNCQEQ
TNSCSVTCTF NIASKDSKKG DPYKISFDRL VGRWNKHGNK LDKKGNKLKK TESDHVFICY
TRCSNSIKCL QDQHSGTCTP TEAFLEFGVT DKESRLEVLK CGLRLVYASD EPQKTNSDMD
LSLSSSDSTP TRNGSSNTTT SSGSVSTNTI REEDSNILHE AQSQNGRGL