RPP30_DICDI
ID RPP30_DICDI Reviewed; 366 AA.
AC Q3ZE13; Q55CN7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Ribonuclease P protein subunit drpp30;
DE EC=3.1.26.5;
DE AltName: Full=RNaseP protein 1;
GN Name=drpp30; Synonyms=rpp1, rpp30; ORFNames=DDB_G0269980;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX4;
RA Vourekas A., Kalavrizioti D., Zarkadis I.K., Stathopoulos C., Drainas D.;
RT "Cloning and characterization of drpp1.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of ribonuclease P, a protein complex that generates
CC mature tRNA molecules by cleaving their 5'-ends. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC from tRNA precursor.; EC=3.1.26.5;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY940192; AAY18218.1; -; mRNA.
DR EMBL; AAFI02000005; EAL72340.1; -; Genomic_DNA.
DR RefSeq; XP_646444.1; XM_641352.1.
DR AlphaFoldDB; Q3ZE13; -.
DR SMR; Q3ZE13; -.
DR STRING; 44689.DDB0232069; -.
DR PaxDb; Q3ZE13; -.
DR EnsemblProtists; EAL72340; EAL72340; DDB_G0269980.
DR GeneID; 8617403; -.
DR KEGG; ddi:DDB_G0269980; -.
DR dictyBase; DDB_G0269980; drpp30.
DR eggNOG; KOG2363; Eukaryota.
DR HOGENOM; CLU_757427_0_0_1; -.
DR InParanoid; Q3ZE13; -.
DR OMA; CCERIDV; -.
DR PhylomeDB; Q3ZE13; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q3ZE13; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; IDA:dictyBase.
DR GO; GO:0000172; C:ribonuclease MRP complex; ISS:dictyBase.
DR GO; GO:0004526; F:ribonuclease P activity; IDA:dictyBase.
DR GO; GO:0033204; F:ribonuclease P RNA binding; IPI:dictyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IDA:dictyBase.
DR GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR GO; GO:0008033; P:tRNA processing; IDA:dictyBase.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR002738; RNase_P_p30.
DR PANTHER; PTHR13031; PTHR13031; 1.
DR Pfam; PF01876; RNase_P_p30; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Nucleus; Reference proteome; tRNA processing.
FT CHAIN 1..366
FT /note="Ribonuclease P protein subunit drpp30"
FT /id="PRO_0000240431"
FT REGION 265..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40745 MW; 7E9B6A63EF8FB09C CRC64;
MVYYDLNIDS SLPEPKIKSM LSLHTKYGYD SVAITHTVEG KIGYKDVCKI KKIQIEDDSE
KSTSSGWMKM GDSNKTIKQY TRLQVICKTM AEFQMITANN PVVQSYDIIS VVPYDVSVFN
AACNSNEIDI ITIDTFSKFI IKPERVRQCI AKGIFIEILY GNLFGIDADR IAFFQIASSL
VRSSFGKNII LSSSGKSSTT LRSPYDLSNL GHLFGLTFDQ AKAAVSKHPH TAVLHAITRR
TKGIATVTDP NLLKDLELWK LERKEDTQPT NNNIPHEKHI NKESTGKETI PKPTTTTTTT
TTTTTTAKTK TPTPTPTTEK TPSIPTQPPQ KPTAKSNKKT TTNTTSTAQK QGKMDIDIDN
NKRKRE
