RPP30_MOUSE
ID RPP30_MOUSE Reviewed; 268 AA.
AC O88796;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Ribonuclease P protein subunit p30;
DE Short=RNaseP protein p30;
DE AltName: Full=RNase P subunit 2;
GN Name=Rpp30; Synonyms=Rnasep2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9630247;
RA Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.;
RT "Autoantigenic properties of some protein subunits of catalytically active
RT complexes of human ribonuclease P.";
RL RNA 4:407-417(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC generates mature tRNA molecules by cleaving their 5'-ends. Also a
CC component of the MRP ribonuclease complex, which cleaves pre-rRNA
CC sequences. {ECO:0000250|UniProtKB:P78346}.
CC -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC RNase P consists of a catalytic RNA moiety and about 10 protein
CC subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC subcomplex. All subunits of the RNase P complex interact with the
CC catalytic RNA. Several subunits of RNase P are also part of the RNase
CC MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC also POP4 and POP5. {ECO:0000250|UniProtKB:P78346}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC component 3 family. {ECO:0000305}.
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DR EMBL; U95123; AAC24115.1; -; mRNA.
DR CCDS; CCDS29770.1; -.
DR RefSeq; NP_062301.3; NM_019428.3.
DR AlphaFoldDB; O88796; -.
DR SMR; O88796; -.
DR BioGRID; 207622; 30.
DR IntAct; O88796; 2.
DR MINT; O88796; -.
DR STRING; 10090.ENSMUSP00000025714; -.
DR iPTMnet; O88796; -.
DR PhosphoSitePlus; O88796; -.
DR EPD; O88796; -.
DR jPOST; O88796; -.
DR MaxQB; O88796; -.
DR PaxDb; O88796; -.
DR PeptideAtlas; O88796; -.
DR PRIDE; O88796; -.
DR ProteomicsDB; 300485; -.
DR Antibodypedia; 16338; 83 antibodies from 21 providers.
DR DNASU; 54364; -.
DR Ensembl; ENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800.
DR GeneID; 54364; -.
DR KEGG; mmu:54364; -.
DR UCSC; uc008hhg.2; mouse.
DR CTD; 10556; -.
DR MGI; MGI:1859683; Rpp30.
DR VEuPathDB; HostDB:ENSMUSG00000024800; -.
DR eggNOG; KOG2363; Eukaryota.
DR GeneTree; ENSGT00390000000883; -.
DR HOGENOM; CLU_048451_2_1_1; -.
DR InParanoid; O88796; -.
DR OMA; PWDVINL; -.
DR OrthoDB; 1197518at2759; -.
DR PhylomeDB; O88796; -.
DR TreeFam; TF106113; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 54364; 25 hits in 74 CRISPR screens.
DR PRO; PR:O88796; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; O88796; protein.
DR Bgee; ENSMUSG00000024800; Expressed in spermatocyte and 275 other tissues.
DR Genevisible; O88796; MM.
DR GO; GO:0030681; C:multimeric ribonuclease P complex; ISO:MGI.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; IBA:GO_Central.
DR GO; GO:0000172; C:ribonuclease MRP complex; ISO:MGI.
DR GO; GO:0004526; F:ribonuclease P activity; ISO:MGI.
DR GO; GO:0033204; F:ribonuclease P RNA binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0001682; P:tRNA 5'-leader removal; ISO:MGI.
DR GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR002738; RNase_P_p30.
DR PANTHER; PTHR13031; PTHR13031; 1.
DR Pfam; PF01876; RNase_P_p30; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome; rRNA processing;
KW tRNA processing.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P78346"
FT CHAIN 2..268
FT /note="Ribonuclease P protein subunit p30"
FT /id="PRO_0000140032"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P78346"
FT MOD_RES 251
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P78346"
SQ SEQUENCE 268 AA; 29473 MW; 068028B3FA99428E CRC64;
MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK PIAVSELFTT
LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY DIVAVFPKTE KLFHVACTHL
DVDLVCITVT EKLPFYFKRP PVNVAIERGL GFELVYGPAI RDATMRRYTI SNALNLMQIC
KGKNVILSSA AERPLEIRGP YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG
IISTVKKPRP SEADDESLPV CKKAKCEG
