RPP38_BOVIN
ID RPP38_BOVIN Reviewed; 282 AA.
AC Q32LC1; G5E591;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Ribonuclease P protein subunit p38;
DE Short=RNaseP protein p38;
GN Name=RPP38;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC generates mature tRNA molecules by cleaving their 5'-ends. Also a
CC component of the MRP ribonuclease complex, which cleaves pre-rRNA
CC sequences. {ECO:0000250|UniProtKB:P78345}.
CC -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC RNase P consists of a catalytic RNA moiety and about 10 protein
CC subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC subcomplex. All subunits of the RNase P complex interact with the
CC catalytic RNA. Several subunits of RNase P are also part of the RNase
CC MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC also POP4 and POP5. {ECO:0000250|UniProtKB:P78345}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P78345}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000305}.
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DR EMBL; DAAA02035539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109652; AAI09653.1; -; mRNA.
DR RefSeq; NP_001033174.1; NM_001038085.2.
DR RefSeq; XP_005214241.1; XM_005214184.3.
DR RefSeq; XP_005214243.1; XM_005214186.1.
DR RefSeq; XP_010809412.1; XM_010811110.2.
DR AlphaFoldDB; Q32LC1; -.
DR SMR; Q32LC1; -.
DR STRING; 9913.ENSBTAP00000010127; -.
DR PaxDb; Q32LC1; -.
DR PRIDE; Q32LC1; -.
DR Ensembl; ENSBTAT00000010127; ENSBTAP00000010127; ENSBTAG00000007702.
DR GeneID; 511723; -.
DR KEGG; bta:511723; -.
DR CTD; 10557; -.
DR VEuPathDB; HostDB:ENSBTAG00000007702; -.
DR VGNC; VGNC:34124; RPP38.
DR eggNOG; KOG3387; Eukaryota.
DR GeneTree; ENSGT00390000007526; -.
DR HOGENOM; CLU_082744_0_0_1; -.
DR InParanoid; Q32LC1; -.
DR OMA; WLQDRTE; -.
DR OrthoDB; 1485783at2759; -.
DR TreeFam; TF332558; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000007702; Expressed in oocyte and 107 other tissues.
DR GO; GO:0001650; C:fibrillar center; IBA:GO_Central.
DR GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR GO; GO:0005655; C:nucleolar ribonuclease P complex; IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0000172; C:ribonuclease MRP complex; IEA:InterPro.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR042848; Rpp38.
DR PANTHER; PTHR46948; PTHR46948; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome; rRNA processing;
KW tRNA processing.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P78345"
FT CHAIN 2..282
FT /note="Ribonuclease P protein subunit p38"
FT /id="PRO_0000254030"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..282
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P78345"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P78345"
FT MOD_RES 226
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P78345"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P78345"
FT CONFLICT 157
FT /note="P -> R (in Ref. 2; AAI09653)"
SQ SEQUENCE 282 AA; 31354 MW; CC95672204BBB9F7 CRC64;
MAAAPQAPGR GSVRKTRPLP VKTSLNNPYS ICWGVLDRED MHFILQTLED RIQSLGLQKI
EDRKRKKKQP PLKKQSGDTS SIDVDTGEDL KKEKPKGDAQ ASGWTPVDVR KQLAIGINEV
TRALERNELL LALACKSAKP AIVTSHLVQL SVSRGVPACQ VPRLSERLAP VLGLKCVLAL
GFKRNTTAFG EELRAILPRV PRLNVAWLQD ALEDPRENLQ TESLESQDEE ILDTSFEDLS
KPKRKLAEGQ QPVVLQPLKI KKLIPNPNKI RKPPKSKRTA SK
