RPP5_ARATH
ID RPP5_ARATH Reviewed; 1449 AA.
AC F4JNB7; B9DG46; O23535; Q0WV14;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Disease resistance protein RPP5 {ECO:0000305};
DE EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};
DE AltName: Full=Protein RECOGNITION OF PERONOSPORA PARASITICA 5 {ECO:0000303|PubMed:9212464};
GN Name=RPP5 {ECO:0000303|PubMed:9212464};
GN OrderedLocusNames=At4g16950 {ECO:0000312|Araport:AT4G16950};
GN ORFNames=dl4505c {ECO:0000312|EMBL:CAB46048.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1374.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1449.
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP FUNCTION.
RX PubMed=9212464; DOI=10.1105/tpc.9.6.879;
RA Parker J.E., Coleman M.J., Szabo V., Frost L.N., Schmidt R.,
RA van der Biezen E.A., Moores T., Dean C., Daniels M.J., Jones J.D.;
RT "The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the
RT toll and interleukin-1 receptors with N and L6.";
RL Plant Cell 9:879-894(1997).
RN [7]
RP INTERACTION WITH RSH1.
RX PubMed=10725385; DOI=10.1073/pnas.97.7.3747;
RA van der Biezen E.A., Sun J., Coleman M.J., Bibb M.J., Jones J.D.;
RT "Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:3747-3752(2000).
RN [8]
RP FUNCTION, AND INTERACTION WITH RSH1.
RX PubMed=11846877; DOI=10.1046/j.0960-7412.2001.01229.x;
RA van der Biezen E.A., Freddie C.T., Kahn K., Parker J.E., Jones J.D.;
RT "Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR
RT genes and confers downy mildew resistance through multiple signalling
RT components.";
RL Plant J. 29:439-451(2002).
CC -!- FUNCTION: TIR-NB-LRR receptor-like protein that confers resistance to
CC the pathogen Hyaloperonospora arabidopsis isolate Noco2 (downy mildew
CC disease) (PubMed:9212464). Confers resistance to H.arabidopsis isolates
CC Emoy2, Emwa1 and Noco2 (PubMed:11846877).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC -!- SUBUNIT: Interacts with RSH1. {ECO:0000269|PubMed:10725385,
CC ECO:0000269|PubMed:11846877}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According EST sequences.
CC {ECO:0000305};
CC Name=1;
CC IsoId=F4JNB7-1; Sequence=Displayed;
CC -!- DOMAIN: The TIR domain mediates NAD(+) hydrolase (NADase) activity.
CC Self-association of TIR domains is required for NADase activity.
CC {ECO:0000255|PROSITE-ProRule:PRU00204}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB46048.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z97342; CAB46048.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161545; CAB80966.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83826.1; -; Genomic_DNA.
DR EMBL; AK226966; BAE99034.1; -; mRNA.
DR EMBL; AK317019; BAH19713.1; -; mRNA.
DR PIR; B85189; B85189.
DR RefSeq; NP_193428.2; NM_117798.4. [F4JNB7-1]
DR AlphaFoldDB; F4JNB7; -.
DR SMR; F4JNB7; -.
DR STRING; 3702.AT4G16950.1; -.
DR iPTMnet; F4JNB7; -.
DR PaxDb; F4JNB7; -.
DR PRIDE; F4JNB7; -.
DR ProteomicsDB; 226559; -. [F4JNB7-1]
DR EnsemblPlants; AT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1]
DR GeneID; 827403; -.
DR Gramene; AT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1]
DR KEGG; ath:AT4G16950; -.
DR Araport; AT4G16950; -.
DR TAIR; locus:2130270; AT4G16950.
DR eggNOG; ENOG502QQJE; Eukaryota.
DR InParanoid; F4JNB7; -.
DR OrthoDB; 221703at2759; -.
DR PhylomeDB; F4JNB7; -.
DR PRO; PR:F4JNB7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JNB7; baseline and differential.
DR Genevisible; F4JNB7; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; TAS:TAIR.
DR GO; GO:0006952; P:defense response; TAS:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; PTHR11017; 5.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF07725; LRR_3; 3.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Hydrolase; Leucine-rich repeat; NAD;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1449
FT /note="Disease resistance protein RPP5"
FT /id="PRO_0000433380"
FT DOMAIN 10..178
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT DOMAIN 192..446
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 549..573
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 574..595
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 597..618
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 619..642
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 644..665
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 687..710
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 712..732
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 733..755
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 756..779
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 802..825
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 826..849
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 915..939
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 941..962
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 963..985
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 986..1011
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 1028..1052
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 1053..1077
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 1096..1119
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 1120..1143
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT ACT_SITE 85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT CONFLICT 972
FT /note="E -> K (in Ref. 5; BAH19713)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1449 AA; 164461 MW; A1CD42BD2D37D075 CRC64;
MAASSSSGRR RYDVFPSFSG VDVRKTFLSH LIEALDGKSI NTFIDHGIER SRTIAPELIS
AIREARISIV IFSKNYASST WCLNELVEIH KCFNDLGQMV IPVFYDVDPS EVRKQTGEFG
KVFEKTCEVS KDKQPGDQKQ RWVQALTDIA NIAGEDLLNG PNEAHMVEKI SNDVSNKLIT
RSKCFDDFVG IEAHIEAIKS VLCLESKEAR MVGIWGQSGI GKSTIGRALF SQLSIQFPLR
AFLTYKSTSG SDVSGMKLSW EKELLSEILG QKDIKIEHFG VVEQRLKHKK VLILLDDVDN
LEFLKTLVGK AEWFGSGSRI IVITQDRQFL KAHDIDLVYE VKLPSQGLAL TMLCRSAFGK
DSPPDDFKEL AFEVAKLAGH LPLGLNVLGS SLRRRGKKEW MEMMPRLRNG LNGDIMKTLR
VSYDRLHQKD QDMFLCIACL FNGFEVSYVK DLLEDNVGLT MLSEKSLIRI TPDGHIEMHN
LLEKLGREID RAKSKGNPGK RQFLTNFEDI HEVVTEKTGT ETLLGIRLPF EEYFSTRPLL
IDKESFKGMR NLQYLKIGDW SDGGQPQSLV YLPLKLRLLD WDDCPLKSLP STFKAEYLVN
LIMKYSKLEK LWEGTLPLGS LKKMNLLCSK NLKEIPDLSN ARNLEELDLE GCESLVTLPS
SIQNAIKLRK LHCSGVILID LKSLEGMCNL EYLSVDCSRV EGTQGIVYFP SKLRLLLWNN
CPLKRLHSNF KVEYLVKLRM ENSDLEKLWD GTQPLGRLKQ MFLRGSKYLK EIPDLSLAIN
LEEVDICKCE SLVTFPSSMQ NAIKLIYLDI SDCKKLESFP TDLNLESLEY LNLTGCPNLR
NFPAIKMGCS DVDFPEGRNE IVVEDCFWNK NLPAGLDYLD CLMRCMPCEF RPEYLVFLNV
RCYKHEKLWE GIQSLGSLEE MDLSESENLT EIPDLSKATN LKHLYLNNCK SLVTLPSTIG
NLQKLVRLEM KECTGLEVLP TDVNLSSLET LDLSGCSSLR TFPLISKSIK WLYLENTAIE
EILDLSKATK LESLILNNCK SLVTLPSTIG NLQNLRRLYM KRCTGLEVLP TDVNLSSLGI
LDLSGCSSLR TFPLISTNIV WLYLENTAIG EVPCCIEDFT RLRVLLMYCC QRLKNISPNI
FRLRSLMFAD FTDCRGVIKA LSDATVVATM EDSVSCVPLS ENIEYTCERF WGELYGDGDW
DLGTEYFSFR NCFKLDRDAR ELILRSCFKP VALPGGEIPK YFTYRAYGDS LTVTLPRSSL
SQSFLRFKAC LVVDPLSEGK GFYRYLEVNF GFNGKQYQKS FLEDEELEFC KTDHLFFCSF
KFESEMTFND VEFKFCCSNR IKECGVRLMY VSQETEYNQQ TTRSKKRMRM TSGTSEEYIN
LAGDQIVADT GLAALNMELS LGEGEASSST SLEGEALSVD YMITKEQDED IPFLDPVSDG
TWRSFYSAE