AUNIP_BOVIN
ID AUNIP_BOVIN Reviewed; 357 AA.
AC A4IFU8;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Aurora kinase A and ninein-interacting protein {ECO:0000305};
GN Name=AUNIP {ECO:0000250|UniProtKB:Q9H7T9};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding protein that accumulates at DNA double-strand
CC breaks (DSBs) following DNA damage and promotes DNA resection and
CC homologous recombination. Serves as a sensor of DNA damage: binds DNA
CC with a strong preference for DNA substrates that mimic structures
CC generated at stalled replication forks, and anchors RBBP8/CtIP to DSB
CC sites to promote DNA end resection and ensuing homologous recombination
CC repair. Inhibits non-homologous end joining (NHEJ). Required for the
CC dynamic movement of AURKA at the centrosomes and spindle apparatus
CC during the cell cycle. {ECO:0000250|UniProtKB:Q9H7T9}.
CC -!- SUBUNIT: Interacts (via C-terminus) with AURKA (via C-terminus).
CC Interacts (via N-terminus) with NIN; this interaction blocks NIN
CC phosphorylation by both AURKA and GSK3B. Identified in a complex with
CC NIN and AURKA. Interacts with RBBP8/CtIP.
CC {ECO:0000250|UniProtKB:Q9H7T9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H7T9}.
CC Chromosome {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250|UniProtKB:Q9H7T9}. Note=Accumulates at sites of DNA damage
CC by binding to DNA substrates that mimick structures generated at
CC stalled replication forks. Localizes to the centrosome in interphase
CC and to the spindle pole in metaphase. {ECO:0000250|UniProtKB:Q9H7T9}.
CC -!- SIMILARITY: Belongs to the AUNIP family. {ECO:0000305}.
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DR EMBL; DAAA02006388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC134777; AAI34778.1; -; mRNA.
DR RefSeq; NP_001077211.1; NM_001083742.1.
DR AlphaFoldDB; A4IFU8; -.
DR STRING; 9913.ENSBTAP00000029039; -.
DR PaxDb; A4IFU8; -.
DR PRIDE; A4IFU8; -.
DR Ensembl; ENSBTAT00000029039; ENSBTAP00000029039; ENSBTAG00000021786.
DR GeneID; 539251; -.
DR KEGG; bta:539251; -.
DR CTD; 79000; -.
DR VEuPathDB; HostDB:ENSBTAG00000021786; -.
DR VGNC; VGNC:26347; AUNIP.
DR eggNOG; ENOG502SFBZ; Eukaryota.
DR GeneTree; ENSGT00390000003280; -.
DR HOGENOM; CLU_835590_0_0_1; -.
DR InParanoid; A4IFU8; -.
DR OMA; HHRMGTP; -.
DR OrthoDB; 1235123at2759; -.
DR TreeFam; TF337334; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000021786; Expressed in oocyte and 103 other tissues.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0090734; C:site of DNA damage; ISS:UniProtKB.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0003684; F:damaged DNA binding; ISS:UniProtKB.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
DR GO; GO:0007051; P:spindle organization; ISS:UniProtKB.
DR InterPro; IPR029286; AUNIP.
DR PANTHER; PTHR14526; PTHR14526; 1.
DR Pfam; PF15334; AIB; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; DNA-binding;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..357
FT /note="Aurora kinase A and ninein-interacting protein"
FT /id="PRO_0000419629"
FT REGION 72..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..357
FT /note="Interaction with AURKA"
FT /evidence="ECO:0000250|UniProtKB:Q9H7T9"
FT REGION 281..357
FT /note="Interaction with RBBP8/CtIP"
FT /evidence="ECO:0000250|UniProtKB:Q9H7T9"
FT COMPBIAS 72..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 292
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H7T9"
SQ SEQUENCE 357 AA; 39634 MW; 9006CD028865CFD8 CRC64;
MRRRGPEKEE EACGVWLDAA ALKRRKTQTQ LIKSSTKMLT LLPGERKAKI SFTQRSCPSA
GTRQTSIASF LTSQQGKTNG ADQRSVSSHT ESQTNKESKE DATQLEHLTQ GLRADFMAPP
LATSTPADIQ EARLSPQSLK ASCQHGIGTP YLTVPCLFRP DTSVCAGASK ASLACSFAHD
LESSCLLDQK EGEDSSCERE WLQGSKKNNY QSVERHSKTT GHKGHQLLDK TNLENVSAKR
SRQAPVLQTY KDSRRGANMK AVKQSSCPIP GFSWDSERND KDSWSQLFTE DSQGQRVIAH
NSRAPFRDVT NDQNQGYGRV PNSLWAQCQD RTTQFNLQPD SLFTQDSEGN QVIRHQA
