ID   AUP1_CAEEL              Reviewed;         390 AA.
AC   P34426;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Lipid droplet-regulating VLDL assembly factor AUP1 homolog {ECO:0000305};
DE   AltName: Full=Ancient ubiquitous protein 1 homolog {ECO:0000305};
GN   ORFNames=F44B9.5 {ECO:0000312|WormBase:F44B9.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y679}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y679}. Lipid droplet
CC       {ECO:0000250|UniProtKB:Q9Y679}.
CC   -!- SIMILARITY: Belongs to the AUP1 family. {ECO:0000305}.
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DR   EMBL; FO080400; CCD63448.1; -; Genomic_DNA.
DR   PIR; S44813; S44813.
DR   RefSeq; NP_498746.1; NM_066345.4.
DR   AlphaFoldDB; P34426; -.
DR   SMR; P34426; -.
DR   BioGRID; 41333; 1.
DR   STRING; 6239.F44B9.5; -.
DR   EPD; P34426; -.
DR   PaxDb; P34426; -.
DR   PeptideAtlas; P34426; -.
DR   EnsemblMetazoa; F44B9.5.1; F44B9.5.1; WBGene00018408.
DR   GeneID; 176127; -.
DR   KEGG; cel:CELE_F44B9.5; -.
DR   UCSC; F44B9.5.1; c. elegans.
DR   CTD; 176127; -.
DR   WormBase; F44B9.5; CE24973; WBGene00018408; -.
DR   eggNOG; KOG2898; Eukaryota.
DR   GeneTree; ENSGT00390000016110; -.
DR   HOGENOM; CLU_045696_0_0_1; -.
DR   InParanoid; P34426; -.
DR   OMA; CLMLIRI; -.
DR   OrthoDB; 1319689at2759; -.
DR   PhylomeDB; P34426; -.
DR   PRO; PR:P34426; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00018408; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR   SMART; SM00546; CUE; 1.
DR   SMART; SM00563; PlsC; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid droplet; Membrane; Reference proteome.
FT   CHAIN           1..390
FT                   /note="Lipid droplet-regulating VLDL assembly factor AUP1
FT                   homolog"
FT                   /id="PRO_0000065340"
FT   TOPO_DOM        1..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y679"
FT   INTRAMEM        33..53
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y679"
FT   TOPO_DOM        54..390
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y679"
FT   DOMAIN          305..347
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
SQ   SEQUENCE   390 AA;  44227 MW;  C8B1DD8E6B83E2F4 CRC64;
     MASPEASSSG NTEDLRIEDL FHQKRNEDTI AKIFSIIYAP VGLIILLIRV FLGFHTFIVA
     CLLRKSAALR MHTLRIMCSI LGIVVEKSGH RDESARVLCA NHVSILDHLA VDILTPCLLP
     SVWDIPSIIR WCFGYVDLGA TRGRDQLVSR AKQLLTREQM PLLAFPEGII TSGEKALIKF
     NTWCFEVSSV VQPVSVRVWR PYPWKVSVSV LGSSWWTDLF YFFALPFTVI TVEYLPKMER
     RENESLEEFT ARVAETLAGN LKIAVSKFGI SDATEAAKRL RTDRERAKKV VVREKTSPRL
     ADPRQMDECA MRIKQSFPSF HLSAIRRDLE KTRSQTTTVN NLKAGKISSS ASDGQTGKVT
     LDAGTWRGVF DNRKWQMIEV NRQKYMNRDS