AB50G_ORYSJ
ID AB50G_ORYSJ Reviewed; 1406 AA.
AC B9GDE5; Q0IN21; Q2QPY9;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=ABC transporter G family member 50 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG50 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 23 {ECO:0000303|PubMed:16506311};
DE Short=OsPDR23 {ECO:0000303|PubMed:16506311};
GN Name=ABCG50 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR23 {ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os12g0512700 {ECO:0000312|EMBL:BAF29894.1},
GN LOC_Os12g32820; ORFNames=OsJ_36269 {ECO:0000312|EMBL:EEE53302.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B9GDE5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B9GDE5-2; Sequence=VSP_057778, VSP_057779, VSP_057780;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABA99103.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF29894.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE53302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DP000011; ABA99103.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008218; BAF29894.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000149; EEE53302.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK102367; BAG95519.1; -; mRNA.
DR EMBL; AK103110; BAG95896.1; -; mRNA.
DR RefSeq; XP_015618069.1; XM_015762583.1. [B9GDE5-1]
DR AlphaFoldDB; B9GDE5; -.
DR SMR; B9GDE5; -.
DR STRING; 4530.OS12T0512700-01; -.
DR PaxDb; B9GDE5; -.
DR PRIDE; B9GDE5; -.
DR GeneID; 4352332; -.
DR KEGG; osa:4352332; -.
DR eggNOG; KOG0065; Eukaryota.
DR OrthoDB; 1022017at2759; -.
DR Proteomes; UP000000763; Chromosome 12.
DR Proteomes; UP000007752; Chromosome 12.
DR Proteomes; UP000059680; Chromosome 12.
DR Genevisible; B9GDE5; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1406
FT /note="ABC transporter G family member 50"
FT /id="PRO_0000433460"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1155..1175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1185..1207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1238..1258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1265..1285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1295..1315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1323..1343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1378..1398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 140..412
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 488..700
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 806..1058
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1131..1345
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 851..858
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 1..227
FT /note="Missing (in isoform 2)"
FT /id="VSP_057778"
FT VAR_SEQ 931..948
FT /note="EFVAEVLETVELDQIKDV -> VCPLEVGTTQTYTDFNNR (in isoform
FT 2)"
FT /id="VSP_057779"
FT VAR_SEQ 949..1406
FT /note="Missing (in isoform 2)"
FT /id="VSP_057780"
FT CONFLICT 506
FT /note="F -> L (in Ref. 5; EEE53302)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1406 AA; 160166 MW; 42E724E133D6F2C7 CRC64;
MSSSSSHHPE FASCTANDDE HHLDEFELEL VVQDVQRQQN NGSANTDQHE RENLLLLDDS
SKSGALKRRL FFDNLLKNVQ DDHIRFLHRQ KERIDRVDVK LPAIEVRYNN LSVEAECRTA
NGDHLPSLWN STKGAFSGLV KLLGLETERA KINVLEDVSG IIKPCRLTLL LGPPGCGKST
LLRALSGKLD KSLKVTGDIS YNGYQLDEFV PEKTAAYISQ YDLHIPEMTV RETLDFSSRC
QGVGRRPKIL KEVSARESAA GIIPDADIDI YMKAISVEAS KRSLQTDYIL KIMGLEICAD
TMVGDAMIRG LSGGQKKRLT TAEMIVGPAR AYFMDEISNG LDSSTTFQII SCFQQLTNIS
EYTMVISLLQ PTPEVFDLFD DLILMAEGKI IYHGPRNEAL NFFEECGFIC PERKEVADFL
QEILSCKDQQ QYWSGPNESY RYISPHELSS MFKENHRGRK LEEPIVSPKS ELGKEALAFN
KYSLQKLEMF KACGAREALL MKRSMFVYVF KTGQLAIIAL VTMSVFLRTR MTTDFTHATY
YMGALFFSIL MIMLNGTPEI SMQIRRLPSF YKQKSYYFYS SWAYAIPASV LKVPVSILDS
LVWICITYYG IGYTASVSRF FCQFLMLCFV HQSVTSLYRF IASYFQTPTA SFFYLFLALT
FFLMFGGFTL PKPSMPGWLN WGFWISPMTY AEIGTVINEF QAPRWQKETI QNITIGNRIL
INHGLYYSWH FYWISIGALF GSIILFYIAF GLALDYITSI EEYHGSRPIK RLCQEQEKDS
NIRKESDGHS NISRAKMTIP VMELPITFHN LNYYIDTPPE MLKQGYPTKR LQLLNNITGA
LRPGVLSALM GVSGAGKTTL LDVLAGRKTG GYIEGDIRIG GYPKVQETFV RILGYCEQAD
IHSPQLTVEE SVTYSAWLRL PSHVDKKTRS EFVAEVLETV ELDQIKDVLV GTPQKNGLSM
EQRKRLTIAV ELVSNPSVIL MDEPTTGLDT RSAAIVIRAV KNICKTGRTV VCTIHQPSTK
IFEAFDELIL MKNGGKIIYN GPIGERSSKV IEYFEKISGV LKVKSNCNPA AWMMDVTSTS
MEVQHNMDFA ILYDESSQHR DIVELVEKLS IPIPNSEILS FSHRFPRNGW IQLKACLWKQ
NLTYWRSPEY NLRRIMLTVI SALVYGVLFW KRAKILNDEQ DLFNVFGAMY LGSTTIGSYN
HQSIIPFSTT ERIVMYREKF AGMYSSWSYS FAQAAIEIPY VFIQVVLYTL IIYPSIGYYW
TTHKFIWFFY TTFCSSLSYI YVGLLLVSLT PNVQVATILA SFFNTMQTLF SGFILPAPQI
PKWWVWLYYL TPTSWTLDAL LTSQYGNIEK EVRAFGETKS VSIFLNDYFG FHKDKLSLVA
AVLIAFPFVL IILFSFSIEK FNFQKR
