ID   RPR1A_PONAB             Reviewed;         312 AA.
AC   Q5R8Y3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Regulation of nuclear pre-mRNA domain-containing protein 1A;
DE   AltName: Full=Cyclin-dependent kinase inhibitor 2B-related protein;
DE   AltName: Full=p15INK4B-related protein;
GN   Name=RPRD1A; Synonyms=P15RS;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat
CC       domain (CTD) of the largest RNA polymerase II subunit POLR2A, and
CC       participates in dephosphorylation of the CTD by RPAP2. May act as a
CC       negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the
CC       cell cycle. {ECO:0000250|UniProtKB:Q96P16}.
CC   -!- SUBUNIT: May form a heterodimer with RPRD1B. Associates with the RNA
CC       polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and
CC       'Ser-7' of the heptad repeats). {ECO:0000250|UniProtKB:Q96P16}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96P16}.
CC   -!- SIMILARITY: Belongs to the UPF0400 (RTT103) family. {ECO:0000305}.
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DR   EMBL; CR859614; CAH91777.1; -; mRNA.
DR   RefSeq; NP_001126030.1; NM_001132558.1.
DR   AlphaFoldDB; Q5R8Y3; -.
DR   SMR; Q5R8Y3; -.
DR   STRING; 9601.ENSPPYP00000010232; -.
DR   Ensembl; ENSPPYT00000033804; ENSPPYP00000024540; ENSPPYG00000009111.
DR   GeneID; 100172978; -.
DR   KEGG; pon:100172978; -.
DR   CTD; 55197; -.
DR   eggNOG; KOG2669; Eukaryota.
DR   GeneTree; ENSGT00950000183094; -.
DR   HOGENOM; CLU_055523_1_0_1; -.
DR   InParanoid; Q5R8Y3; -.
DR   OMA; MAYNDDA; -.
DR   OrthoDB; 1091009at2759; -.
DR   TreeFam; TF320926; -.
DR   Proteomes; UP000001595; Chromosome 18.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016591; C:RNA polymerase II, holoenzyme; ISS:UniProtKB.
DR   GO; GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR006569; CID_dom.
DR   InterPro; IPR032337; CREPT.
DR   InterPro; IPR008942; ENTH_VHS.
DR   Pfam; PF04818; CID; 1.
DR   Pfam; PF16566; CREPT; 1.
DR   SMART; SM00582; RPR; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   PROSITE; PS51391; CID; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96P16"
FT   CHAIN           2..312
FT                   /note="Regulation of nuclear pre-mRNA domain-containing
FT                   protein 1A"
FT                   /id="PRO_0000311346"
FT   DOMAIN          2..133
FT                   /note="CID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT   COILED          244..286
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96P16"
FT   MOD_RES         153
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96P16"
FT   MOD_RES         156
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96P16"
FT   MOD_RES         285
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96P16"
SQ   SEQUENCE   312 AA;  35720 MW;  61785281F31CB328 CRC64;
     MSAFSEAALE KKLSELSNSQ QSVQTLSLWL IHHRKHSRPI VTVWERELRK AKPNRKLTFL
     YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSETDESC KKHLGRVLSI WEERSVYEND
     VLEQLKQALY GDKKPRKRTY EQIKVDENEN CSSLGSPSEP PQTLDLVRAL QDLENAASGD
     AAVHQRIASL PVEVQEVSLL DKITDKESGE RLSKMVEDAC MLLADYNGRL AAEIDDRKQL
     TRMLADFLRC QKEALAEKEH KLEEYKRKLA RVSLVRKELR SRIQSLPDLS RLPNVTGSHM
     HLPFAGDIYS ED