AUR21_RANAE
ID AUR21_RANAE Reviewed; 16 AA.
AC P69017; P82388;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Aurein-2.1;
DE Contains:
DE RecName: Full=Aurein-2.1.1;
OS Ranoidea aurea (Green and golden bell frog) (Litoria aurea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX NCBI_TaxID=8371;
RN [1]
RP PROTEIN SEQUENCE, AMIDATION AT LEU-16, AND FUNCTION.
RC TISSUE=Skin secretion;
RX PubMed=10951191; DOI=10.1046/j.1432-1327.2000.01536.x;
RA Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C.,
RA Tyler M.J.;
RT "The antibiotic and anticancer active aurein peptides from the australian
RT bell frogs Litoria aurea and Litoria raniformis the solution structure of
RT aurein 1.2.";
RL Eur. J. Biochem. 267:5330-5341(2000).
CC -!- FUNCTION: Has antimicrobial activity against B.cereus, L.lactis,
CC L.innocua, M.luteus, S.epidermidis and S.uberis. Probably acts by
CC disturbing membrane functions with its amphipathic structure.
CC {ECO:0000269|PubMed:10951191}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Aurein subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P69017; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT PEPTIDE 1..16
FT /note="Aurein-2.1"
FT /id="PRO_0000010145"
FT PEPTIDE 3..16
FT /note="Aurein-2.1.1"
FT /id="PRO_0000010146"
FT MOD_RES 16
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:10951191"
SQ SEQUENCE 16 AA; 1616 MW; 1D9A5DADB4D240F9 CRC64;
GLLDIVKKVV GAFGSL