ID   RPRML_HUMAN             Reviewed;         120 AA.
AC   Q8N4K4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Reprimo-like protein;
GN   Name=RPRML;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reprimo family. {ECO:0000305}.
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DR   EMBL; CH471231; EAW57693.1; -; Genomic_DNA.
DR   EMBL; BC033942; AAH33942.2; -; mRNA.
DR   EMBL; BC108690; AAI08691.1; -; mRNA.
DR   CCDS; CCDS11508.1; -.
DR   RefSeq; NP_981945.1; NM_203400.4.
DR   AlphaFoldDB; Q8N4K4; -.
DR   BioGRID; 132672; 1.
DR   IntAct; Q8N4K4; 1.
DR   STRING; 9606.ENSP00000318032; -.
DR   PhosphoSitePlus; Q8N4K4; -.
DR   BioMuta; RPRML; -.
DR   DMDM; 74728863; -.
DR   PaxDb; Q8N4K4; -.
DR   PeptideAtlas; Q8N4K4; -.
DR   PRIDE; Q8N4K4; -.
DR   Antibodypedia; 64103; 18 antibodies from 9 providers.
DR   DNASU; 388394; -.
DR   Ensembl; ENST00000322329.5; ENSP00000318032.3; ENSG00000179673.5.
DR   GeneID; 388394; -.
DR   KEGG; hsa:388394; -.
DR   MANE-Select; ENST00000322329.5; ENSP00000318032.3; NM_203400.5; NP_981945.1.
DR   UCSC; uc002ilb.3; human.
DR   CTD; 388394; -.
DR   GeneCards; RPRML; -.
DR   HGNC; HGNC:32422; RPRML.
DR   HPA; ENSG00000179673; Tissue enriched (brain).
DR   neXtProt; NX_Q8N4K4; -.
DR   OpenTargets; ENSG00000179673; -.
DR   PharmGKB; PA142670990; -.
DR   VEuPathDB; HostDB:ENSG00000179673; -.
DR   eggNOG; ENOG502S6BR; Eukaryota.
DR   GeneTree; ENSGT00390000010523; -.
DR   HOGENOM; CLU_170456_0_0_1; -.
DR   InParanoid; Q8N4K4; -.
DR   OMA; MACCNGT; -.
DR   OrthoDB; 1529294at2759; -.
DR   PhylomeDB; Q8N4K4; -.
DR   TreeFam; TF332720; -.
DR   PathwayCommons; Q8N4K4; -.
DR   SignaLink; Q8N4K4; -.
DR   BioGRID-ORCS; 388394; 13 hits in 1053 CRISPR screens.
DR   GenomeRNAi; 388394; -.
DR   Pharos; Q8N4K4; Tdark.
DR   PRO; PR:Q8N4K4; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8N4K4; protein.
DR   Bgee; ENSG00000179673; Expressed in nucleus accumbens and 84 other tissues.
DR   Genevisible; Q8N4K4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR033357; Reprimo-like.
DR   InterPro; IPR043383; Reprimo_fam.
DR   PANTHER; PTHR28649; PTHR28649; 1.
DR   PANTHER; PTHR28649:SF3; PTHR28649:SF3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..120
FT                   /note="Reprimo-like protein"
FT                   /id="PRO_0000312756"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         109
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3URD2"
SQ   SEQUENCE   120 AA;  12312 MW;  07469BBF018B14EC CRC64;
     MNATFLNHSG LEEVDGVGGG AGAALGNRTH GLGTWLGCCP GGAPLAASDG VPAGLAPDER
     SLWVSRVAQI AVLCVLSLTV VFGVFFLGCN LLIKSESMIN FLVQERRPSK DVGAAILGLY