ID   RPRM_BOVIN              Reviewed;         109 AA.
AC   Q1RMT2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein reprimo;
GN   Name=RPRM;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of p53-dependent G2 arrest
CC       of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1
CC       activity and nuclear translocation of the CDC2 cyclin B1 complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reprimo family. {ECO:0000305}.
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DR   EMBL; BC114727; AAI14728.1; -; mRNA.
DR   RefSeq; NP_001074208.1; NM_001080739.1.
DR   AlphaFoldDB; Q1RMT2; -.
DR   STRING; 9913.ENSBTAP00000028688; -.
DR   PaxDb; Q1RMT2; -.
DR   Ensembl; ENSBTAT00000028688; ENSBTAP00000028688; ENSBTAG00000021526.
DR   GeneID; 614739; -.
DR   KEGG; bta:614739; -.
DR   CTD; 56475; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021526; -.
DR   VGNC; VGNC:34129; RPRM.
DR   eggNOG; ENOG502S262; Eukaryota.
DR   GeneTree; ENSGT00390000010523; -.
DR   HOGENOM; CLU_170456_0_0_1; -.
DR   InParanoid; Q1RMT2; -.
DR   OMA; ERNLFIM; -.
DR   OrthoDB; 1529294at2759; -.
DR   TreeFam; TF332720; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000021526; Expressed in vas deferens and 72 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   InterPro; IPR033356; Reprimo.
DR   InterPro; IPR043383; Reprimo_fam.
DR   PANTHER; PTHR28649; PTHR28649; 1.
DR   PANTHER; PTHR28649:SF2; PTHR28649:SF2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..109
FT                   /note="Protein reprimo"
FT                   /id="PRO_0000312751"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJ72"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   109 AA;  11806 MW;  6B26B1BB0EB7AE73 CRC64;
     MNPALGNQTD VAGLFLANSS EALERAMRCC TQASVVTDDG FAEGGPDERS LYIMRVVQIA
     VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE VEAVVVGPY