RPRM_HUMAN
ID RPRM_HUMAN Reviewed; 109 AA.
AC Q9NS64; B2R4V1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein reprimo;
GN Name=RPRM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX PubMed=10930422; DOI=10.1074/jbc.c000235200;
RA Ohki R., Nemoto J., Murasawa H., Oda E., Inazawa J., Tanaka N.,
RA Taniguchi T.;
RT "Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at
RT the G2 phase.";
RL J. Biol. Chem. 275:22627-22630(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the regulation of p53-dependent G2 arrest
CC of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1
CC activity and nuclear translocation of the CDC2 cyclin B1 complex (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NS64; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-1052363, EBI-17979264;
CC Q9NS64; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-1052363, EBI-19125216;
CC Q9NS64; Q13520: AQP6; NbExp=3; IntAct=EBI-1052363, EBI-13059134;
CC Q9NS64; P53367: ARFIP1; NbExp=3; IntAct=EBI-1052363, EBI-2808808;
CC Q9NS64; P07307-3: ASGR2; NbExp=3; IntAct=EBI-1052363, EBI-12808270;
CC Q9NS64; Q12983: BNIP3; NbExp=3; IntAct=EBI-1052363, EBI-749464;
CC Q9NS64; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-1052363, EBI-11532900;
CC Q9NS64; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-1052363, EBI-17953245;
CC Q9NS64; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-1052363, EBI-18041102;
CC Q9NS64; P20138: CD33; NbExp=3; IntAct=EBI-1052363, EBI-3906571;
CC Q9NS64; P19397: CD53; NbExp=3; IntAct=EBI-1052363, EBI-6657396;
CC Q9NS64; Q07108: CD69; NbExp=3; IntAct=EBI-1052363, EBI-2836595;
CC Q9NS64; O00501: CLDN5; NbExp=3; IntAct=EBI-1052363, EBI-18400628;
CC Q9NS64; O95471: CLDN7; NbExp=3; IntAct=EBI-1052363, EBI-740744;
CC Q9NS64; O95484: CLDN9; NbExp=3; IntAct=EBI-1052363, EBI-18341636;
CC Q9NS64; Q6ZS10: CLEC17A; NbExp=4; IntAct=EBI-1052363, EBI-11977093;
CC Q9NS64; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-1052363, EBI-11749983;
CC Q9NS64; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-1052363, EBI-745535;
CC Q9NS64; Q5JRM2: CXorf66; NbExp=3; IntAct=EBI-1052363, EBI-12823659;
CC Q9NS64; Q08426: EHHADH; NbExp=3; IntAct=EBI-1052363, EBI-2339219;
CC Q9NS64; P54849: EMP1; NbExp=3; IntAct=EBI-1052363, EBI-4319440;
CC Q9NS64; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-1052363, EBI-18304435;
CC Q9NS64; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-1052363, EBI-18938272;
CC Q9NS64; Q969F0: FATE1; NbExp=6; IntAct=EBI-1052363, EBI-743099;
CC Q9NS64; Q6PCT2-2: FBXL19; NbExp=3; IntAct=EBI-1052363, EBI-11959077;
CC Q9NS64; P12314: FCGR1A; NbExp=3; IntAct=EBI-1052363, EBI-2869867;
CC Q9NS64; O15552: FFAR2; NbExp=3; IntAct=EBI-1052363, EBI-2833872;
CC Q9NS64; Q7Z6J4: FGD2; NbExp=3; IntAct=EBI-1052363, EBI-1057190;
CC Q9NS64; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-1052363, EBI-3918971;
CC Q9NS64; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-1052363, EBI-12142257;
CC Q9NS64; Q05329: GAD2; NbExp=3; IntAct=EBI-1052363, EBI-9304251;
CC Q9NS64; P36382: GJA5; NbExp=3; IntAct=EBI-1052363, EBI-750433;
CC Q9NS64; O75712: GJB3; NbExp=3; IntAct=EBI-1052363, EBI-3908586;
CC Q9NS64; O95377: GJB5; NbExp=3; IntAct=EBI-1052363, EBI-3909454;
CC Q9NS64; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-1052363, EBI-11427343;
CC Q9NS64; O60883: GPR37L1; NbExp=3; IntAct=EBI-1052363, EBI-2927498;
CC Q9NS64; O15529: GPR42; NbExp=3; IntAct=EBI-1052363, EBI-18076404;
CC Q9NS64; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-1052363, EBI-2867874;
CC Q9NS64; O00291: HIP1; NbExp=3; IntAct=EBI-1052363, EBI-473886;
CC Q9NS64; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-1052363, EBI-18053395;
CC Q9NS64; P48051: KCNJ6; NbExp=3; IntAct=EBI-1052363, EBI-12017638;
CC Q9NS64; Q13571: LAPTM5; NbExp=3; IntAct=EBI-1052363, EBI-2865663;
CC Q9NS64; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-1052363, EBI-2820517;
CC Q9NS64; P43657: LPAR6; NbExp=3; IntAct=EBI-1052363, EBI-2876949;
CC Q9NS64; Q00013: MPP1; NbExp=3; IntAct=EBI-1052363, EBI-711788;
CC Q9NS64; Q96JQ5: MS4A4A; NbExp=4; IntAct=EBI-1052363, EBI-12820341;
CC Q9NS64; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-1052363, EBI-3923617;
CC Q9NS64; P41143: OPRD1; NbExp=3; IntAct=EBI-1052363, EBI-2624456;
CC Q9NS64; P35372-10: OPRM1; NbExp=3; IntAct=EBI-1052363, EBI-12807478;
CC Q9NS64; Q96AL5: PBX3; NbExp=3; IntAct=EBI-1052363, EBI-741171;
CC Q9NS64; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-1052363, EBI-716063;
CC Q9NS64; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-1052363, EBI-742388;
CC Q9NS64; Q96T60: PNKP; NbExp=3; IntAct=EBI-1052363, EBI-1045072;
CC Q9NS64; P57086: SCAND1; NbExp=3; IntAct=EBI-1052363, EBI-745846;
CC Q9NS64; O00560: SDCBP; NbExp=3; IntAct=EBI-1052363, EBI-727004;
CC Q9NS64; Q9HC62: SENP2; NbExp=3; IntAct=EBI-1052363, EBI-714881;
CC Q9NS64; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-1052363, EBI-17595455;
CC Q9NS64; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-1052363, EBI-9978441;
CC Q9NS64; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-1052363, EBI-741850;
CC Q9NS64; Q9Y5W9: SNX11; NbExp=3; IntAct=EBI-1052363, EBI-10329449;
CC Q9NS64; Q9UMY4-1: SNX12; NbExp=3; IntAct=EBI-1052363, EBI-22419305;
CC Q9NS64; O60493: SNX3; NbExp=3; IntAct=EBI-1052363, EBI-727209;
CC Q9NS64; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-1052363, EBI-17498703;
CC Q9NS64; P27105: STOM; NbExp=3; IntAct=EBI-1052363, EBI-1211440;
CC Q9NS64; Q96L08: SUSD3; NbExp=3; IntAct=EBI-1052363, EBI-18194029;
CC Q9NS64; Q17RD7: SYT16; NbExp=3; IntAct=EBI-1052363, EBI-10238936;
CC Q9NS64; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-1052363, EBI-13351685;
CC Q9NS64; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-1052363, EBI-2821497;
CC Q9NS64; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-1052363, EBI-10982110;
CC Q9NS64; Q9BSE2: TMEM79; NbExp=6; IntAct=EBI-1052363, EBI-8649725;
CC Q9NS64; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-1052363, EBI-11742770;
CC Q9NS64; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-1052363, EBI-2548832;
CC Q9NS64; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-1052363, EBI-12195249;
CC Q9NS64; P49638: TTPA; NbExp=3; IntAct=EBI-1052363, EBI-10210710;
CC Q9NS64; Q96P53: WDFY2; NbExp=3; IntAct=EBI-1052363, EBI-9478589;
CC Q9NS64; Q8N966: ZDHHC22; NbExp=3; IntAct=EBI-1052363, EBI-10268111;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- INDUCTION: By p53/TP53, following X-ray irradiation.
CC {ECO:0000269|PubMed:10930422}.
CC -!- MISCELLANEOUS: 'Reprimo' signifies stop/repress.
CC -!- SIMILARITY: Belongs to the reprimo family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/RPRMID42082ch2q23.html";
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DR EMBL; AB043585; BAB01513.1; -; mRNA.
DR EMBL; AK311958; BAG34898.1; -; mRNA.
DR EMBL; AK074808; BAG52007.1; -; mRNA.
DR EMBL; AC012501; AAY14783.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11467.1; -; Genomic_DNA.
DR EMBL; BC002908; AAH02908.1; -; mRNA.
DR CCDS; CCDS2198.1; -.
DR RefSeq; NP_062819.1; NM_019845.2.
DR AlphaFoldDB; Q9NS64; -.
DR BioGRID; 121145; 103.
DR IntAct; Q9NS64; 77.
DR MINT; Q9NS64; -.
DR STRING; 9606.ENSP00000314946; -.
DR GlyGen; Q9NS64; 2 sites.
DR PhosphoSitePlus; Q9NS64; -.
DR BioMuta; RPRM; -.
DR PaxDb; Q9NS64; -.
DR PeptideAtlas; Q9NS64; -.
DR PRIDE; Q9NS64; -.
DR Antibodypedia; 54148; 90 antibodies from 15 providers.
DR DNASU; 56475; -.
DR Ensembl; ENST00000325926.4; ENSP00000314946.3; ENSG00000177519.4.
DR GeneID; 56475; -.
DR KEGG; hsa:56475; -.
DR MANE-Select; ENST00000325926.4; ENSP00000314946.3; NM_019845.3; NP_062819.1.
DR UCSC; uc002tyq.1; human.
DR CTD; 56475; -.
DR DisGeNET; 56475; -.
DR GeneCards; RPRM; -.
DR HGNC; HGNC:24201; RPRM.
DR HPA; ENSG00000177519; Low tissue specificity.
DR MIM; 612171; gene.
DR neXtProt; NX_Q9NS64; -.
DR OpenTargets; ENSG00000177519; -.
DR PharmGKB; PA134937494; -.
DR VEuPathDB; HostDB:ENSG00000177519; -.
DR eggNOG; ENOG502S262; Eukaryota.
DR GeneTree; ENSGT00390000010523; -.
DR HOGENOM; CLU_170456_0_0_1; -.
DR InParanoid; Q9NS64; -.
DR OMA; ERNLFIM; -.
DR OrthoDB; 1529294at2759; -.
DR PhylomeDB; Q9NS64; -.
DR TreeFam; TF332720; -.
DR PathwayCommons; Q9NS64; -.
DR SignaLink; Q9NS64; -.
DR BioGRID-ORCS; 56475; 8 hits in 1077 CRISPR screens.
DR GenomeRNAi; 56475; -.
DR Pharos; Q9NS64; Tbio.
DR PRO; PR:Q9NS64; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NS64; protein.
DR Bgee; ENSG00000177519; Expressed in cortical plate and 122 other tissues.
DR Genevisible; Q9NS64; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; TAS:ProtInc.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR InterPro; IPR033356; Reprimo.
DR InterPro; IPR043383; Reprimo_fam.
DR PANTHER; PTHR28649; PTHR28649; 1.
DR PANTHER; PTHR28649:SF2; PTHR28649:SF2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..109
FT /note="Protein reprimo"
FT /id="PRO_0000312752"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ72"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 109 AA; 11774 MW; 7026A0AB1FB6BE62 CRC64;
MNPALGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS LYIMRVVQIA
VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE VEAVVVGPY
