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RPRM_RAT
ID   RPRM_RAT                Reviewed;         109 AA.
AC   Q5BJN9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein reprimo;
GN   Name=Rprm;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of p53-dependent G2 arrest
CC       of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1
CC       activity and nuclear translocation of the CDC2 cyclin B1 complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reprimo family. {ECO:0000305}.
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DR   EMBL; BC091400; AAH91400.1; -; mRNA.
DR   RefSeq; NP_001037741.1; NM_001044276.1.
DR   AlphaFoldDB; Q5BJN9; -.
DR   STRING; 10116.ENSRNOP00000006784; -.
DR   GlyGen; Q5BJN9; 2 sites.
DR   PaxDb; Q5BJN9; -.
DR   Ensembl; ENSRNOT00000006784; ENSRNOP00000006784; ENSRNOG00000005109.
DR   GeneID; 680110; -.
DR   KEGG; rno:680110; -.
DR   UCSC; RGD:1595512; rat.
DR   CTD; 56475; -.
DR   RGD; 1595512; Rprm.
DR   eggNOG; ENOG502S262; Eukaryota.
DR   GeneTree; ENSGT00390000010523; -.
DR   HOGENOM; CLU_170456_0_0_1; -.
DR   InParanoid; Q5BJN9; -.
DR   OMA; ERNLFIM; -.
DR   OrthoDB; 1529294at2759; -.
DR   PhylomeDB; Q5BJN9; -.
DR   TreeFam; TF332720; -.
DR   PRO; PR:Q5BJN9; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000005109; Expressed in frontal cortex and 16 other tissues.
DR   Genevisible; Q5BJN9; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISO:RGD.
DR   InterPro; IPR033356; Reprimo.
DR   InterPro; IPR043383; Reprimo_fam.
DR   PANTHER; PTHR28649; PTHR28649; 1.
DR   PANTHER; PTHR28649:SF2; PTHR28649:SF2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..109
FT                   /note="Protein reprimo"
FT                   /id="PRO_0000312754"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJ72"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   109 AA;  11792 MW;  CB41827381CF59EF CRC64;
     MNSVLGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS LYIMRVVQIA
     VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE VEAVVVGPY
 
 
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