RPR_DROME
ID RPR_DROME Reviewed; 65 AA.
AC Q24475; A0JQ43; Q4V3S2; Q9VVP7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Cell death protein rpr;
DE AltName: Full=Protein reaper;
GN Name=rpr; ORFNames=CG4319;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R; TISSUE=Eye imaginal disk;
RX PubMed=8171319; DOI=10.1126/science.8171319;
RA White K., Grether M.E., Abrams J.M., Young L., Farrell K., Steller H.;
RT "Genetic control of programmed cell death in Drosophila.";
RL Science 264:677-683(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RC TISSUE=Embryo;
RX PubMed=9740659; DOI=10.1006/dbio.1998.9000;
RA Chen P., Rodriguez A., Erskine R., Thach T., Abrams J.M.;
RT "Dredd, a novel effector of the apoptosis activators reaper, grim, and hid
RT in Drosophila.";
RL Dev. Biol. 201:202-216(1998).
RN [6]
RP INTERACTION WITH DIAP2.
RX PubMed=18166655; DOI=10.1083/jcb.200706027;
RA Ribeiro P.S., Kuranaga E., Tenev T., Leulier F., Miura M., Meier P.;
RT "DIAP2 functions as a mechanism-based regulator of drICE that contributes
RT to the caspase activity threshold in living cells.";
RL J. Cell Biol. 179:1467-1480(2007).
CC -!- FUNCTION: Activator of apoptosis, as well as grim and hid, that acts on
CC the effector Dredd. {ECO:0000269|PubMed:8171319,
CC ECO:0000269|PubMed:9740659}.
CC -!- SUBUNIT: Interacts with Diap2 (via BIR2 domain).
CC {ECO:0000269|PubMed:18166655}.
CC -!- INTERACTION:
CC Q24475; Q24306: Diap1; NbExp=6; IntAct=EBI-106786, EBI-456419;
CC -!- DEVELOPMENTAL STAGE: Expression coincides with the onset of programmed
CC cell death (PCD) at all stages of embryonic development.
CC {ECO:0000269|PubMed:8171319}.
CC -!- MISCELLANEOUS: Ectopic expression in the developing eye results in a
CC small eye owing to excess cell death.
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DR EMBL; L31631; AAA18983.1; -; mRNA.
DR EMBL; AE014296; AAF49264.1; -; Genomic_DNA.
DR EMBL; BT023284; AAY55700.1; -; mRNA.
DR EMBL; BT029413; ABK57070.1; -; mRNA.
DR RefSeq; NP_524138.1; NM_079414.3.
DR AlphaFoldDB; Q24475; -.
DR SMR; Q24475; -.
DR BioGRID; 65299; 95.
DR DIP; DIP-21897N; -.
DR ELM; Q24475; -.
DR IntAct; Q24475; 2.
DR STRING; 7227.FBpp0074886; -.
DR PaxDb; Q24475; -.
DR DNASU; 40015; -.
DR EnsemblMetazoa; FBtr0075120; FBpp0074886; FBgn0011706.
DR GeneID; 40015; -.
DR KEGG; dme:Dmel_CG4319; -.
DR CTD; 40015; -.
DR FlyBase; FBgn0011706; rpr.
DR VEuPathDB; VectorBase:FBgn0011706; -.
DR eggNOG; ENOG502TCC9; Eukaryota.
DR HOGENOM; CLU_2851998_0_0_1; -.
DR InParanoid; Q24475; -.
DR OMA; RESQWRF; -.
DR OrthoDB; 1603515at2759; -.
DR PhylomeDB; Q24475; -.
DR SignaLink; Q24475; -.
DR BioGRID-ORCS; 40015; 0 hits in 1 CRISPR screen.
DR ChiTaRS; rpr; fly.
DR GenomeRNAi; 40015; -.
DR PRO; PR:Q24475; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0011706; Expressed in saliva-secreting gland and 42 other tissues.
DR Genevisible; Q24475; DM.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0005543; F:phospholipid binding; IDA:FlyBase.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IPI:FlyBase.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:FlyBase.
DR GO; GO:0006915; P:apoptotic process; IDA:FlyBase.
DR GO; GO:0097190; P:apoptotic signaling pathway; IMP:FlyBase.
DR GO; GO:0008219; P:cell death; IMP:FlyBase.
DR GO; GO:0071480; P:cellular response to gamma radiation; IMP:FlyBase.
DR GO; GO:0071479; P:cellular response to ionizing radiation; IDA:FlyBase.
DR GO; GO:0035072; P:ecdysone-mediated induction of salivary gland cell autophagic cell death; IEP:FlyBase.
DR GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:FlyBase.
DR GO; GO:0035193; P:larval central nervous system remodeling; TAS:FlyBase.
DR GO; GO:0035096; P:larval midgut cell programmed cell death; IGI:FlyBase.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:FlyBase.
DR GO; GO:2001056; P:positive regulation of cysteine-type endopeptidase activity; IDA:FlyBase.
DR GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IDA:FlyBase.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IDA:FlyBase.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:FlyBase.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IGI:FlyBase.
DR GO; GO:0012501; P:programmed cell death; IMP:FlyBase.
DR GO; GO:0042176; P:regulation of protein catabolic process; IDA:FlyBase.
DR GO; GO:0035071; P:salivary gland cell autophagic cell death; IGI:FlyBase.
PE 1: Evidence at protein level;
KW Apoptosis; Reference proteome.
FT CHAIN 1..65
FT /note="Cell death protein rpr"
FT /id="PRO_0000097437"
SQ SEQUENCE 65 AA; 7682 MW; 57F231379AFEEA3C CRC64;
MAVAFYIPDQ ATLLREAEQK EQQILRLRES QWRFLATVVL ETLRQYTSCH PKTGRKSGKY
RKPSQ
